ENSG00000125503

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263433 ENSG00000125503 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R12C protein_coding protein_coding 52.63065 76.24365 26.34334 7.873753 0.5859448 -1.53282 13.360015 21.008379 7.149060 1.4780473 0.2652058 -1.5538094 0.2537958 0.27730000 0.2720333 -0.005266667 0.95304103 2.770064e-07 FALSE TRUE
ENST00000588277 ENSG00000125503 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R12C protein_coding retained_intron 52.63065 76.24365 26.34334 7.873753 0.5859448 -1.53282 8.229455 8.759775 4.801944 2.0480341 0.6792033 -0.8659200 0.1631125 0.11196667 0.1831333 0.071166667 0.18967363 2.770064e-07 FALSE FALSE
ENST00000590268 ENSG00000125503 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R12C protein_coding retained_intron 52.63065 76.24365 26.34334 7.873753 0.5859448 -1.53282 3.401526 3.783681 2.748206 0.5602725 0.8397405 -0.4598681 0.0708375 0.04926667 0.1030333 0.053766667 0.16166300 2.770064e-07 FALSE FALSE
ENST00000591938 ENSG00000125503 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R12C protein_coding protein_coding 52.63065 76.24365 26.34334 7.873753 0.5859448 -1.53282 14.732306 26.024981 4.897951 2.1769653 0.7202946 -2.4072587 0.2653542 0.34486667 0.1854333 -0.159433333 0.01180886 2.770064e-07 FALSE TRUE
ENST00000592993 ENSG00000125503 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R12C protein_coding protein_coding 52.63065 76.24365 26.34334 7.873753 0.5859448 -1.53282 6.073212 9.485310 3.088894 1.1632795 0.3459914 -1.6154616 0.1126833 0.12466667 0.1178333 -0.006833333 0.92149692 2.770064e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125503 E001 4.3500329 0.0038470322 2.471863e-01 3.826124e-01 19 55090914 55090917 4 - 0.461 0.672 0.967
ENSG00000125503 E002 313.9104095 0.0067406119 5.780904e-02 1.228725e-01 19 55090918 55091161 244 - 2.303 2.400 0.326
ENSG00000125503 E003 280.5645998 0.0078857423 3.682252e-01 5.126297e-01 19 55091162 55091207 46 - 2.289 2.345 0.187
ENSG00000125503 E004 469.2534538 0.0043841338 3.076407e-01 4.498669e-01 19 55091208 55091360 153 - 2.517 2.566 0.162
ENSG00000125503 E005 343.2347447 0.0048490103 3.739505e-01 5.183747e-01 19 55091361 55091415 55 - 2.384 2.430 0.155
ENSG00000125503 E006 447.2234559 0.0035674986 4.978695e-01 6.344004e-01 19 55091416 55091558 143 - 2.510 2.542 0.108
ENSG00000125503 E007 306.5967908 0.0001993706 1.895613e-02 4.923676e-02 19 55091650 55091700 51 - 2.312 2.379 0.223
ENSG00000125503 E008 266.2804452 0.0002279296 1.191956e-01 2.187869e-01 19 55091859 55091909 51 - 2.264 2.313 0.163
ENSG00000125503 E009 302.3187633 0.0006710393 3.820812e-01 5.263267e-01 19 55092222 55092326 105 - 2.334 2.366 0.104
ENSG00000125503 E010 11.9759491 0.0210028450 7.567050e-02 1.525821e-01 19 55092327 55092441 115 - 1.173 0.958 -0.780
ENSG00000125503 E011 250.2418646 0.0014603897 5.467711e-01 6.768858e-01 19 55092442 55092544 103 - 2.255 2.284 0.096
ENSG00000125503 E012 10.0489969 0.0018018027 3.409463e-04 1.544026e-03 19 55092545 55092598 54 - 1.224 0.838 -1.422
ENSG00000125503 E013 168.8813762 0.0051598551 1.927270e-01 3.171911e-01 19 55092622 55092653 32 - 2.046 2.124 0.260
ENSG00000125503 E014 123.0055220 0.0054925388 9.623731e-01 9.802712e-01 19 55092654 55092662 9 - 1.971 1.976 0.017
ENSG00000125503 E015 1.3693978 0.2345166283 4.447689e-01 5.863244e-01 19 55092776 55092782 7 - 0.462 0.267 -1.165
ENSG00000125503 E016 116.6418360 0.0048893311 6.437294e-01 7.562061e-01 19 55092783 55092789 7 - 1.925 1.957 0.109
ENSG00000125503 E017 218.0797181 0.0025095430 4.831505e-01 6.212132e-01 19 55092790 55092865 76 - 2.191 2.227 0.120
ENSG00000125503 E018 45.5609515 0.0005015414 1.841914e-01 3.064928e-01 19 55092866 55092868 3 - 1.468 1.562 0.323
ENSG00000125503 E019 219.3289865 0.0052073953 4.476559e-01 5.890321e-01 19 55093016 55093076 61 - 2.188 2.233 0.152
ENSG00000125503 E020 49.8937864 0.0147654585 1.393149e-02 3.806781e-02 19 55093077 55093152 76 - 1.732 1.547 -0.630
ENSG00000125503 E021 212.6136417 0.0025365350 1.726677e-01 2.916726e-01 19 55093153 55093185 33 - 2.162 2.222 0.201
ENSG00000125503 E022 232.1612864 0.0012858325 9.652073e-01 9.821021e-01 19 55093186 55093233 48 - 2.244 2.251 0.022
ENSG00000125503 E023 304.0496665 0.0008215113 7.562194e-01 8.413483e-01 19 55094345 55094435 91 - 2.367 2.364 -0.011
ENSG00000125503 E024 354.9353196 0.0001559081 4.001847e-01 5.438815e-01 19 55094661 55094798 138 - 2.444 2.428 -0.053
ENSG00000125503 E025 15.9849006 0.0011948788 7.141539e-15 2.406944e-13 19 55094799 55095161 363 - 1.560 0.897 -2.356
ENSG00000125503 E026 221.3781086 0.0005008160 1.453124e-01 2.552810e-01 19 55095291 55095358 68 - 2.261 2.221 -0.135
ENSG00000125503 E027 240.0255379 0.0017033975 3.329854e-01 4.766672e-01 19 55095445 55095600 156 - 2.289 2.261 -0.093
ENSG00000125503 E028 54.0647490 0.0004925452 5.958552e-01 7.178783e-01 19 55095601 55095603 3 - 1.596 1.632 0.123
ENSG00000125503 E029 194.9189994 0.0002017827 8.501524e-01 9.070620e-01 19 55095867 55095940 74 - 2.164 2.174 0.033
ENSG00000125503 E030 136.6966833 0.0002368606 1.543519e-01 2.675711e-01 19 55096051 55096076 26 - 1.969 2.029 0.201
ENSG00000125503 E031 232.8981678 0.0002020100 6.181532e-01 7.358586e-01 19 55096077 55096178 102 - 2.255 2.245 -0.035
ENSG00000125503 E032 4.6309281 0.0066596071 8.725500e-01 9.220274e-01 19 55096179 55096261 83 - 0.680 0.656 -0.100
ENSG00000125503 E033 189.2741458 0.0002233036 3.631525e-01 5.075819e-01 19 55096262 55096335 74 - 2.129 2.163 0.115
ENSG00000125503 E034 0.6611159 0.0217879486 2.228873e-02 5.627343e-02 19 55096852 55097064 213 - 0.461 0.068 -3.490
ENSG00000125503 E035 214.3613527 0.0002133894 5.972526e-01 7.190419e-01 19 55098784 55098858 75 - 2.195 2.215 0.068
ENSG00000125503 E036 244.8738206 0.0002260818 6.875778e-01 7.898875e-01 19 55098951 55099095 145 - 2.275 2.267 -0.025
ENSG00000125503 E037 252.8154736 0.0030770380 2.130200e-02 5.422445e-02 19 55103409 55103568 160 - 2.349 2.271 -0.259
ENSG00000125503 E038 9.9146520 0.0314343065 7.274912e-01 8.201752e-01 19 55111376 55112466 1091 - 0.963 0.920 -0.162
ENSG00000125503 E039 199.0965134 0.0002722198 2.016213e-03 7.277056e-03 19 55112467 55112585 119 - 2.252 2.161 -0.304
ENSG00000125503 E040 1.3252757 0.0123501763 5.420639e-01 6.729160e-01 19 55112586 55112664 79 - 0.212 0.337 0.898
ENSG00000125503 E041 166.8814164 0.0002045099 1.806369e-04 8.807392e-04 19 55112665 55112795 131 - 2.200 2.081 -0.398
ENSG00000125503 E042 6.8310169 0.0025872481 6.880238e-03 2.091293e-02 19 55112796 55113391 596 - 1.045 0.702 -1.321
ENSG00000125503 E043 12.5942088 0.0020247093 5.077872e-06 3.608627e-05 19 55113392 55115516 2125 - 1.351 0.906 -1.602
ENSG00000125503 E044 73.7627652 0.0050784657 4.333106e-11 8.126858e-10 19 55117223 55117637 415 - 2.024 1.664 -1.211