ENSG00000125482

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334270 ENSG00000125482 HEK293_OSMI2_2hA HEK293_TMG_2hB TTF1 protein_coding protein_coding 10.5498 5.586681 16.39451 0.9839578 0.5742087 1.551449 6.5821690 2.1137933 11.2198492 0.19147725 0.5943493 2.402623 0.5663917 0.3896667 0.68400000 0.2943333 3.761891e-06 1.43438e-19 FALSE TRUE
ENST00000461970 ENSG00000125482 HEK293_OSMI2_2hA HEK293_TMG_2hB TTF1 protein_coding processed_transcript 10.5498 5.586681 16.39451 0.9839578 0.5742087 1.551449 0.5674035 1.2007310 0.4234401 0.76152832 0.2346858 -1.481974 0.0864000 0.1837667 0.02573333 -0.1580333 6.375936e-01 1.43438e-19   FALSE
ENST00000612514 ENSG00000125482 HEK293_OSMI2_2hA HEK293_TMG_2hB TTF1 protein_coding protein_coding 10.5498 5.586681 16.39451 0.9839578 0.5742087 1.551449 0.9265684 1.8776153 0.0000000 0.19510206 0.0000000 -7.560421 0.1479917 0.3543667 0.00000000 -0.3543667 1.434380e-19 1.43438e-19 FALSE TRUE
MSTRG.33551.7 ENSG00000125482 HEK293_OSMI2_2hA HEK293_TMG_2hB TTF1 protein_coding   10.5498 5.586681 16.39451 0.9839578 0.5742087 1.551449 1.6566577 0.2995202 3.4400677 0.07611927 0.7350526 3.478519 0.1325542 0.0526000 0.20730000 0.1547000 7.009068e-04 1.43438e-19 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125482 E001 20.9271653 0.0048919619 9.037215e-04 3.626890e-03 9 132375548 132375734 187 - 1.195 1.478 0.987
ENSG00000125482 E002 32.3223853 0.0133529580 4.401173e-04 1.928460e-03 9 132375735 132375775 41 - 1.362 1.663 1.033
ENSG00000125482 E003 47.7132669 0.0008824569 3.070150e-06 2.291508e-05 9 132375776 132375845 70 - 1.544 1.805 0.888
ENSG00000125482 E004 56.8862791 0.0035677052 3.113315e-05 1.845736e-04 9 132375846 132375928 83 - 1.625 1.867 0.822
ENSG00000125482 E005 102.3086063 0.0061932586 1.966686e-05 1.222224e-04 9 132375929 132376168 240 - 1.885 2.112 0.764
ENSG00000125482 E006 62.0856153 0.0004968137 1.691217e-04 8.314199e-04 9 132379059 132379144 86 - 1.683 1.872 0.640
ENSG00000125482 E007 1.6325479 0.0616457991 1.003356e-01 1.909888e-01 9 132379145 132379205 61 - 0.277 0.597 1.725
ENSG00000125482 E008 58.2214233 0.0004666455 5.899491e-03 1.834504e-02 9 132386556 132386621 66 - 1.675 1.821 0.494
ENSG00000125482 E009 67.9311929 0.0005011692 6.496574e-01 7.608628e-01 9 132388139 132388228 90 - 1.788 1.776 -0.042
ENSG00000125482 E010 41.1579910 0.0005848112 3.304724e-01 4.740585e-01 9 132390597 132390603 7 - 1.586 1.534 -0.178
ENSG00000125482 E011 126.6917092 0.0035627036 4.515979e-01 5.925417e-01 9 132390604 132390831 228 - 2.059 2.037 -0.074
ENSG00000125482 E012 100.8269352 0.0011319227 5.624221e-01 6.900220e-01 9 132392076 132392206 131 - 1.958 1.943 -0.051
ENSG00000125482 E013 81.4238482 0.0144950386 8.071656e-01 8.775163e-01 9 132396433 132396511 79 - 1.856 1.879 0.076
ENSG00000125482 E014 100.7054978 0.0089362090 6.950994e-01 7.957777e-01 9 132398141 132398326 186 - 1.957 1.942 -0.050
ENSG00000125482 E015 91.9613582 0.0003186028 2.420581e-02 6.023456e-02 9 132400035 132400258 224 - 1.938 1.851 -0.292
ENSG00000125482 E016 60.9258650 0.0003966856 1.680477e-03 6.220302e-03 9 132401455 132401554 100 - 1.777 1.616 -0.545
ENSG00000125482 E017 76.0057474 0.0004400572 1.558262e-03 5.823793e-03 9 132401555 132401723 169 - 1.869 1.725 -0.484
ENSG00000125482 E018 63.2399852 0.0004389508 2.609189e-05 1.575066e-04 9 132401724 132401915 192 - 1.804 1.584 -0.749
ENSG00000125482 E019 118.4694326 0.0003464203 2.136325e-05 1.315693e-04 9 132401916 132402520 605 - 2.060 1.905 -0.520
ENSG00000125482 E020 71.1770299 0.0008519648 4.236462e-06 3.063184e-05 9 132402521 132402828 308 - 1.856 1.622 -0.792
ENSG00000125482 E021 0.8815316 0.0136968632 1.497641e-01 2.613591e-01 9 132403828 132403911 84 - 0.316 0.001 -9.193
ENSG00000125482 E022 15.9226285 0.0012831313 1.045187e-02 2.986810e-02 9 132406790 132406851 62 - 1.233 0.968 -0.955