ENSG00000125454

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402418 ENSG00000125454 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A19 protein_coding protein_coding 54.14271 100.1268 29.11041 4.383912 0.6153827 -1.78187 2.279833 2.166946 1.919840 0.1958653 0.1214686 -0.1738245 0.05367083 0.02156667 0.0662000 0.04463333 1.861116e-09 1.861116e-09 FALSE  
ENST00000416858 ENSG00000125454 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A19 protein_coding protein_coding 54.14271 100.1268 29.11041 4.383912 0.6153827 -1.78187 8.550148 14.885853 4.404676 2.3278238 0.3216893 -1.7545312 0.15645417 0.14716667 0.1511667 0.00400000 9.593583e-01 1.861116e-09 FALSE  
ENST00000442286 ENSG00000125454 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A19 protein_coding protein_coding 54.14271 100.1268 29.11041 4.383912 0.6153827 -1.78187 20.948920 43.980050 10.163378 0.7952814 0.2058058 -2.1123784 0.36077917 0.44073333 0.3491333 -0.09160000 1.405506e-02 1.861116e-09 FALSE  
ENST00000580994 ENSG00000125454 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A19 protein_coding protein_coding 54.14271 100.1268 29.11041 4.383912 0.6153827 -1.78187 10.621892 19.044482 4.631060 1.1603847 0.1209752 -2.0376040 0.19824167 0.19030000 0.1592667 -0.03103333 2.796963e-01 1.861116e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125454 E001 7.402677 0.0027044174 3.635528e-01 5.079614e-01 17 75272981 75272991 11 - 0.698 0.838 0.561
ENSG00000125454 E002 8.472339 0.0171326821 2.470836e-01 3.825034e-01 17 75272992 75272992 1 - 0.698 0.886 0.747
ENSG00000125454 E003 102.062483 0.0029916694 3.932309e-02 8.977203e-02 17 75272993 75273029 37 - 1.789 1.904 0.389
ENSG00000125454 E004 651.460212 0.0017357121 1.933113e-03 7.018713e-03 17 75273030 75273288 259 - 2.613 2.698 0.284
ENSG00000125454 E005 879.763121 0.0006835811 1.264607e-04 6.432607e-04 17 75273289 75273550 262 - 2.751 2.827 0.253
ENSG00000125454 E006 500.536335 0.0003169281 2.335826e-01 3.666544e-01 17 75273551 75273639 89 - 2.548 2.575 0.091
ENSG00000125454 E007 524.923088 0.0018895872 8.695144e-01 9.201281e-01 17 75277353 75277483 131 - 2.586 2.593 0.023
ENSG00000125454 E008 469.342272 0.0025949293 6.810157e-01 7.848313e-01 17 75278152 75278237 86 - 2.530 2.545 0.051
ENSG00000125454 E009 455.633090 0.0001239717 5.924328e-01 7.149886e-01 17 75278238 75278335 98 - 2.517 2.530 0.042
ENSG00000125454 E010 213.438349 0.0002523289 6.905928e-01 7.922509e-01 17 75283423 75283428 6 - 2.187 2.201 0.046
ENSG00000125454 E011 490.268649 0.0005321387 5.039703e-01 6.398958e-01 17 75283429 75283564 136 - 2.571 2.557 -0.045
ENSG00000125454 E012 318.815745 0.0004991879 9.798569e-01 9.914542e-01 17 75283565 75283593 29 - 2.371 2.373 0.007
ENSG00000125454 E013 316.709898 0.0001574234 5.261998e-01 6.594580e-01 17 75286304 75286334 31 - 2.355 2.373 0.059
ENSG00000125454 E014 389.053600 0.0001685607 4.801192e-01 6.184280e-01 17 75286335 75286399 65 - 2.444 2.461 0.060
ENSG00000125454 E015 404.431104 0.0001375764 6.647703e-02 1.375177e-01 17 75286400 75286459 60 - 2.439 2.483 0.147
ENSG00000125454 E016 284.783133 0.0001727146 5.503643e-01 6.800119e-01 17 75286633 75286646 14 - 2.311 2.328 0.059
ENSG00000125454 E017 542.399330 0.0002486258 1.172876e-01 2.160729e-01 17 75286647 75286802 156 - 2.627 2.598 -0.099
ENSG00000125454 E018 52.776454 0.0006176412 2.509333e-21 1.868654e-19 17 75286803 75287674 872 - 1.961 1.470 -1.665
ENSG00000125454 E019 22.114919 0.0013877961 5.486786e-11 1.011438e-09 17 75288120 75288387 268 - 1.612 1.107 -1.760
ENSG00000125454 E020 113.128037 0.0003009894 1.821337e-02 4.759659e-02 17 75288388 75288461 74 - 2.003 1.907 -0.324
ENSG00000125454 E021 11.703951 0.0130245324 5.397227e-03 1.700689e-02 17 75288462 75288497 36 - 1.229 0.905 -1.179
ENSG00000125454 E022 14.101963 0.0015717891 1.004470e-02 2.887220e-02 17 75288498 75288501 4 - 1.262 1.003 -0.930
ENSG00000125454 E023 85.655714 0.0047608737 3.503637e-03 1.173539e-02 17 75288502 75288553 52 - 1.935 1.774 -0.541
ENSG00000125454 E024 66.888086 0.0029876392 4.138210e-04 1.827524e-03 17 75288554 75288591 38 - 1.858 1.661 -0.668
ENSG00000125454 E025 12.075836 0.0015676853 2.405793e-05 1.465405e-04 17 75289010 75289088 79 - 1.321 0.895 -1.543
ENSG00000125454 E026 54.442638 0.0145839053 3.805211e-04 1.699321e-03 17 75289089 75289353 265 - 1.833 1.554 -0.946
ENSG00000125454 E027 194.272625 0.0075717830 7.443187e-03 2.236923e-02 17 75289354 75289510 157 - 2.266 2.135 -0.440