ENSG00000125375

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000426751 ENSG00000125375 HEK293_OSMI2_2hA HEK293_TMG_2hB DMAC2L protein_coding protein_coding 11.84614 12.53144 15.559 1.535024 0.447013 0.3119727 0.9848571 1.5485765 0.5460633 0.15605455 0.1016787 -1.48690787 0.09196250 0.12563333 0.03516667 -0.09046667 4.221108e-05 3.661331e-11 FALSE TRUE
ENST00000555939 ENSG00000125375 HEK293_OSMI2_2hA HEK293_TMG_2hB DMAC2L protein_coding processed_transcript 11.84614 12.53144 15.559 1.535024 0.447013 0.3119727 5.0842503 4.6730142 6.7091879 1.38294925 0.2342199 0.52084946 0.42360417 0.35806667 0.43126667 0.07320000 6.214597e-01 3.661331e-11 FALSE TRUE
ENST00000556962 ENSG00000125375 HEK293_OSMI2_2hA HEK293_TMG_2hB DMAC2L protein_coding retained_intron 11.84614 12.53144 15.559 1.535024 0.447013 0.3119727 0.6852595 0.5922446 0.9952290 0.09231239 0.1308635 0.73910284 0.05822917 0.04863333 0.06403333 0.01540000 6.482393e-01 3.661331e-11 FALSE FALSE
ENST00000557421 ENSG00000125375 HEK293_OSMI2_2hA HEK293_TMG_2hB DMAC2L protein_coding protein_coding 11.84614 12.53144 15.559 1.535024 0.447013 0.3119727 2.3288056 1.4485853 4.9817333 0.18185523 0.1166031 1.77497111 0.17373750 0.11680000 0.32030000 0.20350000 3.661331e-11 3.661331e-11 FALSE TRUE
MSTRG.9517.1 ENSG00000125375 HEK293_OSMI2_2hA HEK293_TMG_2hB DMAC2L protein_coding   11.84614 12.53144 15.559 1.535024 0.447013 0.3119727 0.6202383 0.6981192 0.7144548 0.10585918 0.3662140 0.03290336 0.05312500 0.05616667 0.04493333 -0.01123333 8.011673e-01 3.661331e-11 FALSE TRUE
MSTRG.9517.9 ENSG00000125375 HEK293_OSMI2_2hA HEK293_TMG_2hB DMAC2L protein_coding   11.84614 12.53144 15.559 1.535024 0.447013 0.3119727 1.3427013 2.8926328 0.6259116 0.24026613 0.3241682 -2.19046384 0.12375833 0.24146667 0.04070000 -0.20076667 1.619016e-01 3.661331e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125375 E001 0.0000000       14 50312314 50312323 10 +      
ENSG00000125375 E002 0.0000000       14 50312324 50312326 3 +      
ENSG00000125375 E003 0.2214452 0.0437114558 3.975542e-01   14 50312327 50312328 2 + 0.000 0.134 9.156
ENSG00000125375 E004 37.6684277 0.0005737772 9.442411e-03 2.738951e-02 14 50312329 50312389 61 + 1.513 1.658 0.495
ENSG00000125375 E005 6.6868485 0.0228837351 4.043027e-03 1.326279e-02 14 50312390 50313060 671 + 1.043 0.627 -1.632
ENSG00000125375 E006 23.7534189 0.0008565559 4.382548e-01 5.801501e-01 14 50314591 50314626 36 + 1.421 1.366 -0.189
ENSG00000125375 E007 0.4460135 0.0373771895 1.253791e-01 2.276819e-01 14 50319234 50319301 68 + 0.275 0.000 -13.063
ENSG00000125375 E008 2.1776625 0.0070742700 7.263612e-01 8.194165e-01 14 50321319 50321376 58 + 0.486 0.545 0.281
ENSG00000125375 E009 73.3742130 0.0004451935 1.116967e-01 2.080526e-01 14 50321483 50321532 50 + 1.843 1.907 0.212
ENSG00000125375 E010 101.5256925 0.0002916702 2.642682e-03 9.198866e-03 14 50321533 50321594 62 + 1.963 2.064 0.337
ENSG00000125375 E011 94.3822556 0.0003198367 1.111345e-02 3.143764e-02 14 50322511 50322541 31 + 1.939 2.027 0.297
ENSG00000125375 E012 174.8369250 0.0002368455 4.381227e-08 4.779789e-07 14 50322542 50322719 178 + 2.177 2.313 0.453
ENSG00000125375 E013 30.1150078 0.0007144416 2.736798e-18 1.427135e-16 14 50322720 50322806 87 + 1.107 1.700 2.058
ENSG00000125375 E014 11.6350454 0.0371552446 3.045191e-08 3.423346e-07 14 50322807 50322892 86 + 0.526 1.343 3.156
ENSG00000125375 E015 89.6524535 0.0005544561 4.497257e-06 3.235699e-05 14 50323945 50324116 172 + 2.040 1.872 -0.563
ENSG00000125375 E016 5.7195139 0.0028595227 9.349931e-01 9.630802e-01 14 50324117 50324291 175 + 0.839 0.829 -0.040
ENSG00000125375 E017 2.3927555 0.0346947894 3.923099e-02 8.961035e-02 14 50324547 50324706 160 + 0.684 0.317 -1.837
ENSG00000125375 E018 65.3941610 0.0004527041 4.131909e-01 5.567185e-01 14 50325609 50325645 37 + 1.843 1.809 -0.115
ENSG00000125375 E019 255.0123108 0.0003120386 1.773203e-25 2.038398e-23 14 50325646 50327957 2312 + 2.505 2.292 -0.708
ENSG00000125375 E020 5.9207611 0.0706690281 6.119819e-01 7.310169e-01 14 50332022 50332236 215 + 0.891 0.781 -0.426
ENSG00000125375 E021 0.0000000       14 50335459 50335558 100 +