ENSG00000124942

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257247 ENSG00000124942 HEK293_OSMI2_2hA HEK293_TMG_2hB AHNAK protein_coding protein_coding 4.072818 4.354657 3.229335 0.3697965 0.2099833 -0.4301704 0.2849314 0.4563305 0.2778452 0.1289531 0.1587528 -0.6960596 0.07840833 0.1110333 0.08633333 -0.0247000 8.372029e-01 4.731131e-06 FALSE TRUE
ENST00000378024 ENSG00000124942 HEK293_OSMI2_2hA HEK293_TMG_2hB AHNAK protein_coding protein_coding 4.072818 4.354657 3.229335 0.3697965 0.2099833 -0.4301704 1.8495886 1.3096484 2.0661408 0.1970666 0.1336186 0.6537507 0.48670417 0.2974667 0.64263333 0.3451667 4.731131e-06 4.731131e-06 FALSE TRUE
ENST00000525875 ENSG00000124942 HEK293_OSMI2_2hA HEK293_TMG_2hB AHNAK protein_coding processed_transcript 4.072818 4.354657 3.229335 0.3697965 0.2099833 -0.4301704 1.7801787 2.1997192 0.8073454 0.1675772 0.1014820 -1.4348452 0.39760417 0.5108333 0.24806667 -0.2627667 1.752838e-03 4.731131e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124942 E001 0.0000000       11 62433542 62433545 4 -      
ENSG00000124942 E002 0.0000000       11 62433546 62433546 1 -      
ENSG00000124942 E003 9.0307993 0.1320717881 1.490344e-01 2.603662e-01 11 62433547 62433891 345 - 0.879 1.052 0.645
ENSG00000124942 E004 5.9568632 0.1337435679 4.164216e-01 5.597802e-01 11 62491732 62491810 79 - 0.810 0.850 0.156
ENSG00000124942 E005 4.2102489 0.1627454694 1.135437e-01 2.106953e-01 11 62491811 62491831 21 - 0.549 0.792 1.031
ENSG00000124942 E006 149.6514364 0.0038803105 1.027336e-36 2.862143e-34 11 62515902 62517009 1108 - 1.904 2.281 1.262
ENSG00000124942 E007 298.8161236 0.0002441089 8.918126e-26 1.050039e-23 11 62517010 62519658 2649 - 2.427 2.485 0.194
ENSG00000124942 E008 38.7440115 0.0005885610 3.452152e-01 4.892974e-01 11 62519659 62519937 279 - 1.639 1.556 -0.282
ENSG00000124942 E009 18.3678558 0.0063550562 2.213795e-01 3.520793e-01 11 62519938 62520030 93 - 1.410 1.175 -0.825
ENSG00000124942 E010 16.5417702 0.0036273924 2.545771e-01 3.912902e-01 11 62520031 62520070 40 - 1.351 1.123 -0.806
ENSG00000124942 E011 36.4598896 0.0023609197 6.553135e-01 7.652398e-01 11 62520071 62520321 251 - 1.646 1.485 -0.551
ENSG00000124942 E012 24.8801631 0.0119739705 4.822513e-01 6.204107e-01 11 62520322 62520454 133 - 1.504 1.315 -0.654
ENSG00000124942 E013 439.7744622 0.0153239080 1.057771e-14 3.466980e-13 11 62520455 62533983 13529 - 2.842 2.409 -1.441
ENSG00000124942 E014 4.0650693 0.0046178074 3.593800e-01 5.037158e-01 11 62533984 62534045 62 - 0.833 0.592 -0.998
ENSG00000124942 E015 2.8043362 0.0054167261 4.657406e-01 6.053774e-01 11 62534046 62534074 29 - 0.699 0.483 -0.972
ENSG00000124942 E016 10.9648966 0.0174979745 2.909751e-01 4.317872e-01 11 62535003 62535087 85 - 1.076 1.070 -0.021
ENSG00000124942 E017 9.2163234 0.0023407117 6.245338e-01 7.408180e-01 11 62535088 62535190 103 - 1.048 0.975 -0.268
ENSG00000124942 E018 15.8495404 0.0024440413 1.222628e-01 2.231718e-01 11 62535945 62536098 154 - 1.221 1.223 0.009
ENSG00000124942 E019 0.0000000       11 62536099 62536107 9 -      
ENSG00000124942 E020 0.3697384 0.0255378846 1.738795e-01 2.932360e-01 11 62536239 62536287 49 - 0.000 0.199 11.432
ENSG00000124942 E021 10.5972608 0.0044951165 3.337004e-01 4.774417e-01 11 62536469 62536567 99 - 1.076 1.049 -0.098
ENSG00000124942 E022 0.7268175 0.7459535387 2.498522e-01 3.857336e-01 11 62545566 62545687 122 - 0.000 0.339 11.188
ENSG00000124942 E023 4.9886691 0.0322774842 5.865060e-01 7.100701e-01 11 62546660 62546833 174 - 0.878 0.680 -0.789
ENSG00000124942 E024 0.1515154 0.0430661447 5.336275e-01   11 62556188 62556235 48 - 0.135 0.000 -11.618