ENSG00000124795

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000244776 ENSG00000124795 HEK293_OSMI2_2hA HEK293_TMG_2hB DEK protein_coding protein_coding 133.1038 33.34383 254.512 3.138157 11.49028 2.931866 6.785894 0.03209025 18.008444 0.03209025 5.2001697 8.7417728 0.02927917 0.001066667 0.07096667 0.06990000 1.862948e-05 2.062577e-99 FALSE TRUE
ENST00000651624 ENSG00000124795 HEK293_OSMI2_2hA HEK293_TMG_2hB DEK protein_coding protein_coding 133.1038 33.34383 254.512 3.138157 11.49028 2.931866 14.235936 5.96104469 30.363302 0.83677296 3.7552845 2.3467485 0.13366250 0.179600000 0.11853333 -0.06106667 1.585375e-01 2.062577e-99 FALSE TRUE
ENST00000651992 ENSG00000124795 HEK293_OSMI2_2hA HEK293_TMG_2hB DEK protein_coding protein_coding 133.1038 33.34383 254.512 3.138157 11.49028 2.931866 14.288190 8.48872023 4.527057 1.18192717 0.8097171 -0.9054889 0.18053333 0.252933333 0.01783333 -0.23510000 3.269712e-24 2.062577e-99 FALSE TRUE
ENST00000652576 ENSG00000124795 HEK293_OSMI2_2hA HEK293_TMG_2hB DEK protein_coding protein_coding 133.1038 33.34383 254.512 3.138157 11.49028 2.931866 34.598832 0.00000000 76.943598 0.00000000 3.8106684 12.9097731 0.15259583 0.000000000 0.30236667 0.30236667 2.062577e-99 2.062577e-99 FALSE TRUE
ENST00000652689 ENSG00000124795 HEK293_OSMI2_2hA HEK293_TMG_2hB DEK protein_coding protein_coding 133.1038 33.34383 254.512 3.138157 11.49028 2.931866 6.224480 4.27186056 10.817894 0.23415812 0.7701890 1.3384430 0.07275833 0.130233333 0.04256667 -0.08766667 9.180073e-10 2.062577e-99 FALSE TRUE
MSTRG.27700.2 ENSG00000124795 HEK293_OSMI2_2hA HEK293_TMG_2hB DEK protein_coding   133.1038 33.34383 254.512 3.138157 11.49028 2.931866 28.203818 10.06654182 44.032138 0.80722853 7.1534414 2.1278839 0.24293750 0.302933333 0.17243333 -0.13050000 1.020027e-02 2.062577e-99 FALSE TRUE
MSTRG.27700.8 ENSG00000124795 HEK293_OSMI2_2hA HEK293_TMG_2hB DEK protein_coding   133.1038 33.34383 254.512 3.138157 11.49028 2.931866 23.204325 2.47605064 59.444303 1.28710120 1.7138854 4.5798536 0.12956250 0.074166667 0.23426667 0.16010000 4.671630e-01 2.062577e-99 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124795 E001 19.7532608 0.0047126232 1.132655e-12 2.753473e-11 6 18223860 18224184 325 - 1.001 1.656 2.295
ENSG00000124795 E002 12.9210002 0.0088161440 1.723216e-13 4.742274e-12 6 18224185 18224190 6 - 0.761 1.559 2.884
ENSG00000124795 E003 12.4781097 0.0192720259 1.236406e-10 2.149325e-09 6 18224191 18224192 2 - 0.761 1.536 2.806
ENSG00000124795 E004 63.0341132 0.0150844104 7.131778e-13 1.792139e-11 6 18224193 18224216 24 - 1.509 2.102 2.004
ENSG00000124795 E005 163.5703960 0.0096826113 1.009782e-22 8.715270e-21 6 18224217 18224251 35 - 1.911 2.517 2.027
ENSG00000124795 E006 420.5670062 0.0124354788 3.614231e-17 1.639227e-15 6 18224252 18224345 94 - 2.345 2.887 1.804
ENSG00000124795 E007 2226.8502718 0.0071408096 5.222908e-14 1.546763e-12 6 18224346 18225024 679 - 3.138 3.475 1.122
ENSG00000124795 E008 565.1729933 0.0017644929 5.447982e-10 8.484905e-09 6 18225025 18225084 60 - 2.574 2.792 0.728
ENSG00000124795 E009 361.0021272 0.0005373992 2.468010e-27 3.299626e-25 6 18225085 18225168 84 - 2.353 2.668 1.050
ENSG00000124795 E010 915.9117512 0.0005090160 9.234335e-32 1.738983e-29 6 18225169 18225469 301 - 2.773 3.028 0.848
ENSG00000124795 E011 723.6546789 0.0001076078 1.230167e-08 1.492197e-07 6 18225470 18225610 141 - 2.695 2.844 0.493
ENSG00000124795 E012 710.4783396 0.0007301879 8.499237e-01 9.068741e-01 6 18225611 18225665 55 - 2.706 2.761 0.184
ENSG00000124795 E013 738.8882504 0.0022071129 4.688409e-01 6.081971e-01 6 18225666 18225730 65 - 2.727 2.758 0.102
ENSG00000124795 E014 25.5714486 0.0188709313 8.087441e-01 8.785315e-01 6 18225731 18225871 141 - 1.277 1.353 0.266
ENSG00000124795 E015 22.0966928 0.0403846148 6.644315e-01 7.722413e-01 6 18225872 18226009 138 - 1.211 1.322 0.392
ENSG00000124795 E016 15.0298581 0.0106521176 3.845124e-01 5.286609e-01 6 18226010 18226173 164 - 1.049 1.199 0.540
ENSG00000124795 E017 659.1297700 0.0041448906 6.175061e-01 7.352857e-01 6 18226174 18226242 69 - 2.677 2.712 0.116
ENSG00000124795 E018 929.9947945 0.0028540353 5.862430e-03 1.825146e-02 6 18236452 18236596 145 - 2.837 2.807 -0.103
ENSG00000124795 E019 355.3561376 0.0012231565 1.599023e-06 1.270467e-05 6 18236597 18236600 4 - 2.432 2.326 -0.354
ENSG00000124795 E020 0.6266857 0.0168461465 1.006100e-01 1.913838e-01 6 18237050 18237380 331 - 0.100 0.422 2.671
ENSG00000124795 E021 991.7718713 0.0030905275 4.011697e-07 3.615968e-06 6 18237381 18237516 136 - 2.876 2.771 -0.349
ENSG00000124795 E022 10.2395881 0.0024972743 4.502873e-01 5.914018e-01 6 18244508 18244603 96 - 0.894 1.036 0.531
ENSG00000124795 E023 20.5628474 0.0025903452 7.209518e-02 1.468246e-01 6 18244604 18246124 1521 - 1.223 1.068 -0.557
ENSG00000124795 E024 592.2380746 0.0013738386 2.618426e-10 4.297064e-09 6 18249651 18249688 38 - 2.654 2.527 -0.422
ENSG00000124795 E025 832.0791677 0.0001325419 2.859097e-17 1.315809e-15 6 18249689 18249764 76 - 2.799 2.693 -0.353
ENSG00000124795 E026 871.2087209 0.0002645433 6.964490e-16 2.687173e-14 6 18249765 18249839 75 - 2.819 2.717 -0.339
ENSG00000124795 E027 481.8593891 0.0001460863 5.335985e-11 9.856537e-10 6 18255731 18255735 5 - 2.563 2.455 -0.358
ENSG00000124795 E028 938.1973085 0.0001015410 1.033054e-16 4.436839e-15 6 18255736 18255851 116 - 2.850 2.759 -0.305
ENSG00000124795 E029 756.3826886 0.0001073690 3.206156e-13 8.482009e-12 6 18256361 18256455 95 - 2.755 2.667 -0.294
ENSG00000124795 E030 10.0733833 0.1060150994 8.381052e-02 1.655163e-01 6 18256526 18257952 1427 - 0.825 1.239 1.524
ENSG00000124795 E031 723.9790480 0.0004408628 8.464657e-18 4.201215e-16 6 18257953 18258031 79 - 2.743 2.605 -0.461
ENSG00000124795 E032 663.6441327 0.0007431512 3.999412e-21 2.919756e-19 6 18258032 18258062 31 - 2.711 2.528 -0.612
ENSG00000124795 E033 708.9191428 0.0011059207 4.830120e-19 2.759276e-17 6 18258304 18258356 53 - 2.739 2.558 -0.603
ENSG00000124795 E034 715.0054393 0.0021339544 2.329604e-19 1.386979e-17 6 18258357 18258405 49 - 2.748 2.522 -0.754
ENSG00000124795 E035 898.5672240 0.0068540052 1.949237e-13 5.317166e-12 6 18263843 18263996 154 - 2.852 2.580 -0.904
ENSG00000124795 E036 4.2654747 0.2169496657 7.432117e-01 8.319295e-01 6 18263997 18264097 101 - 0.582 0.722 0.597
ENSG00000124795 E037 5.8743032 0.0067174831 1.479430e-01 2.588773e-01 6 18264098 18264275 178 - 0.664 0.925 1.037
ENSG00000124795 E038 472.8056500 0.0176021425 1.174465e-07 1.177616e-06 6 18264385 18264587 203 - 2.577 2.258 -1.065