ENSG00000124789

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262077 ENSG00000124789 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP153 protein_coding protein_coding 34.6736 16.95643 56.6751 0.7090307 1.36584 1.740287 22.13507 16.35215 33.67527 0.6793058 1.6349098 1.041755 0.7154125 0.9644 0.5936000 -0.3708000 6.776331e-49 3.735402e-73 FALSE TRUE
MSTRG.27692.5 ENSG00000124789 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP153 protein_coding   34.6736 16.95643 56.6751 0.7090307 1.36584 1.740287 10.43565 0.00000 19.87852 0.0000000 0.7209734 10.957720 0.2249792 0.0000 0.3507667 0.3507667 3.735402e-73 3.735402e-73 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124789 E001 1.406963 1.060037e-02 2.476192e-01 3.831510e-01 6 17615035 17615036 2 - 0.284 0.518 1.314
ENSG00000124789 E002 168.914904 6.244028e-03 1.855445e-56 1.642563e-53 6 17615037 17615181 145 - 1.785 2.593 2.704
ENSG00000124789 E003 304.461785 4.387180e-03 7.779442e-101 2.497953e-97 6 17615182 17615463 282 - 1.992 2.865 2.911
ENSG00000124789 E004 374.557482 8.706501e-03 1.305606e-20 8.972195e-19 6 17615464 17615708 245 - 2.326 2.822 1.651
ENSG00000124789 E005 265.913537 6.195353e-03 8.514091e-15 2.831260e-13 6 17615709 17615779 71 - 2.234 2.622 1.293
ENSG00000124789 E006 568.953850 4.187728e-03 3.116654e-15 1.106108e-13 6 17615780 17616181 402 - 2.598 2.910 1.036
ENSG00000124789 E007 432.121302 7.812759e-04 7.369460e-11 1.328501e-09 6 17616527 17616695 169 - 2.530 2.716 0.621
ENSG00000124789 E008 555.601463 1.190013e-03 1.056041e-03 4.153546e-03 6 17624561 17624833 273 - 2.663 2.780 0.388
ENSG00000124789 E009 666.906362 9.943237e-05 4.547005e-06 3.267892e-05 6 17625808 17626164 357 - 2.744 2.857 0.375
ENSG00000124789 E010 760.592855 1.835414e-04 2.508486e-01 3.869565e-01 6 17628655 17629080 426 - 2.818 2.879 0.202
ENSG00000124789 E011 534.261350 1.184879e-04 5.020699e-04 2.167532e-03 6 17629081 17629395 315 - 2.688 2.670 -0.057
ENSG00000124789 E012 411.626997 2.019905e-04 2.733821e-06 2.065295e-05 6 17629396 17629539 144 - 2.584 2.531 -0.177
ENSG00000124789 E013 439.016030 1.640091e-04 4.330131e-04 1.901377e-03 6 17632650 17632844 195 - 2.604 2.579 -0.084
ENSG00000124789 E014 888.061537 7.694602e-04 1.542285e-12 3.663256e-11 6 17637153 17637770 618 - 2.925 2.837 -0.295
ENSG00000124789 E015 260.348657 4.812019e-03 8.038389e-04 3.272832e-03 6 17639939 17640046 108 - 2.396 2.297 -0.333
ENSG00000124789 E016 123.004311 2.893224e-03 2.624717e-02 6.445168e-02 6 17640047 17640064 18 - 2.062 2.004 -0.193
ENSG00000124789 E017 183.795881 6.155642e-03 2.747883e-02 6.696659e-02 6 17646067 17646154 88 - 2.238 2.173 -0.215
ENSG00000124789 E018 253.384942 2.043691e-03 2.036603e-07 1.948701e-06 6 17647807 17647905 99 - 2.394 2.259 -0.449
ENSG00000124789 E019 312.785117 1.938411e-04 7.026772e-22 5.516788e-20 6 17649163 17649300 138 - 2.497 2.303 -0.647
ENSG00000124789 E020 1.922896 7.899738e-03 3.504159e-01 4.945892e-01 6 17651834 17651926 93 - 0.481 0.332 -0.823
ENSG00000124789 E021 293.436609 5.862686e-04 2.339620e-17 1.087157e-15 6 17661653 17661779 127 - 2.469 2.281 -0.626
ENSG00000124789 E022 202.384949 6.856925e-03 1.505151e-06 1.203251e-05 6 17662018 17662070 53 - 2.310 2.110 -0.670
ENSG00000124789 E023 297.075885 1.049455e-03 7.038458e-21 5.010953e-19 6 17665239 17665385 147 - 2.482 2.246 -0.790
ENSG00000124789 E024 170.330778 2.031225e-03 2.405662e-11 4.711522e-10 6 17668975 17669028 54 - 2.240 2.016 -0.752
ENSG00000124789 E025 172.757720 4.425162e-04 4.936592e-14 1.466326e-12 6 17669293 17669337 45 - 2.243 2.030 -0.714
ENSG00000124789 E026 263.947212 1.011674e-03 4.029142e-20 2.598940e-18 6 17669430 17669546 117 - 2.432 2.188 -0.812
ENSG00000124789 E027 269.463255 9.588502e-04 6.251588e-24 6.165250e-22 6 17674905 17675033 129 - 2.446 2.175 -0.902
ENSG00000124789 E028 285.539001 1.395456e-02 1.966080e-05 1.221887e-04 6 17675229 17675368 140 - 2.463 2.234 -0.763
ENSG00000124789 E029 353.223463 9.352842e-03 6.437831e-10 9.900380e-09 6 17675522 17675770 249 - 2.565 2.279 -0.956
ENSG00000124789 E030 266.777454 1.874590e-04 5.189290e-36 1.352263e-33 6 17688396 17688618 223 - 2.448 2.141 -1.025
ENSG00000124789 E031 250.090081 1.114820e-02 2.925069e-06 2.193854e-05 6 17706277 17707347 1071 - 2.407 2.177 -0.769