ENSG00000124787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319533 ENSG00000124787 HEK293_OSMI2_2hA HEK293_TMG_2hB RPP40 protein_coding protein_coding 18.55306 16.52686 28.22673 2.641848 0.1594652 0.7718879 6.044297 6.512734 8.044860 1.2983800 0.5354349 0.3043827 0.3392708 0.3894333 0.28510000 -0.1043333 0.04124128 0.04124128 FALSE TRUE
ENST00000464646 ENSG00000124787 HEK293_OSMI2_2hA HEK293_TMG_2hB RPP40 protein_coding protein_coding 18.55306 16.52686 28.22673 2.641848 0.1594652 0.7718879 1.777767 2.382592 2.611728 0.2705456 0.3010266 0.1319434 0.1030250 0.1497667 0.09246667 -0.0573000 0.23629785 0.04124128 FALSE TRUE
ENST00000468105 ENSG00000124787 HEK293_OSMI2_2hA HEK293_TMG_2hB RPP40 protein_coding retained_intron 18.55306 16.52686 28.22673 2.641848 0.1594652 0.7718879 4.507876 4.002651 7.714953 0.5709478 0.7968251 0.9449705 0.2252292 0.2458333 0.27353333 0.0277000 0.81689249 0.04124128 FALSE FALSE
ENST00000618533 ENSG00000124787 HEK293_OSMI2_2hA HEK293_TMG_2hB RPP40 protein_coding protein_coding 18.55306 16.52686 28.22673 2.641848 0.1594652 0.7718879 4.951334 2.540765 7.870499 0.8299866 1.4960506 1.6273572 0.2577458 0.1471000 0.27856667 0.1314667 0.17623641 0.04124128 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124787 E001 3.1536661 0.0309957486 1.248238e-01 0.2268714486 6 4993089 4993131 43 - 0.723 0.456 -1.204
ENSG00000124787 E002 4.0997151 0.0040038109 8.642613e-02 0.1696872523 6 4993132 4993210 79 - 0.807 0.556 -1.060
ENSG00000124787 E003 5.0172267 0.0323891906 2.956366e-02 0.0711016341 6 4993565 4993622 58 - 0.911 0.557 -1.456
ENSG00000124787 E004 2.6466023 0.0216054936 1.421822e-01 0.2510087412 6 4994717 4995046 330 - 0.433 0.673 1.117
ENSG00000124787 E005 1.5812780 0.0107291944 3.748715e-02 0.0863801192 6 4995047 4995048 2 - 0.196 0.556 2.189
ENSG00000124787 E006 4.1568046 0.0059028994 1.527554e-02 0.0411112711 6 4995049 4995077 29 - 0.516 0.864 1.467
ENSG00000124787 E007 120.1770749 0.0002924898 8.436714e-03 0.0248779712 6 4995078 4995276 199 - 2.051 2.132 0.271
ENSG00000124787 E008 153.0725524 0.0002256049 1.394115e-01 0.2472346753 6 4995951 4996085 135 - 2.176 2.215 0.132
ENSG00000124787 E009 159.1911801 0.0002935607 7.415892e-01 0.8306991600 6 4996222 4996420 199 - 2.206 2.214 0.027
ENSG00000124787 E010 6.3954011 0.0026492956 1.095108e-01 0.2048469788 6 4998688 4998715 28 - 0.767 0.962 0.752
ENSG00000124787 E011 95.8481837 0.0003432158 2.077372e-05 0.0001283642 6 4998716 4998827 112 - 1.915 2.063 0.496
ENSG00000124787 E012 36.8019858 0.0005626560 5.741399e-05 0.0003186532 6 4998828 4998841 14 - 1.462 1.689 0.776
ENSG00000124787 E013 123.6663410 0.0003368432 2.861066e-01 0.4264955681 6 4999809 4999904 96 - 2.118 2.085 -0.110
ENSG00000124787 E014 101.8187779 0.0003082878 9.805783e-02 0.1875625881 6 5000563 5000631 69 - 2.045 1.989 -0.187
ENSG00000124787 E015 0.1482932 0.0411597534 3.752783e-01   6 5001094 5001130 37 - 0.000 0.137 8.628
ENSG00000124787 E016 0.7374030 0.0156879985 2.767756e-01 0.4162542704 6 5001776 5002100 325 - 0.331 0.137 -1.621
ENSG00000124787 E017 152.1396320 0.0002438696 2.361869e-05 0.0001440642 6 5002101 5002245 145 - 2.244 2.129 -0.384
ENSG00000124787 E018 6.3287833 0.0061366869 7.848135e-01 0.8620262048 6 5003586 5003879 294 - 0.879 0.842 -0.143
ENSG00000124787 E019 96.5949985 0.0003776549 9.195392e-05 0.0004841823 6 5003880 5004063 184 - 2.057 1.919 -0.462