ENSG00000124784

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379834 ENSG00000124784 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOK1 protein_coding protein_coding 38.06613 19.42721 51.13059 1.010149 1.238664 1.395648 32.809716 17.38847 43.883678 0.6965728 1.3202340 1.335053 0.8685542 0.8963333 0.85810000 -0.03823333 3.445001e-01 2.377331e-13 FALSE TRUE
ENST00000475351 ENSG00000124784 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOK1 protein_coding nonsense_mediated_decay 38.06613 19.42721 51.13059 1.010149 1.238664 1.395648 2.370867 0.00000 3.405088 0.0000000 0.6271265 8.415779 0.0434875 0.0000000 0.06626667 0.06626667 2.377331e-13 2.377331e-13 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124784 E001 0.4762024 0.3012391693 8.988705e-01 9.394907e-01 6 7389791 7389791 1 + 0.158 0.172 0.144
ENSG00000124784 E002 0.4762024 0.3012391693 8.988705e-01 9.394907e-01 6 7389792 7389792 1 + 0.158 0.172 0.144
ENSG00000124784 E003 2.9077658 0.0058095506 8.526628e-01 9.086883e-01 6 7389793 7389807 15 + 0.560 0.591 0.139
ENSG00000124784 E004 259.6733194 0.0125247538 1.106514e-04 5.708916e-04 6 7389808 7390073 266 + 2.464 2.236 -0.762
ENSG00000124784 E005 113.0425224 0.0181104708 2.745632e-03 9.508823e-03 6 7393099 7393107 9 + 2.105 1.876 -0.769
ENSG00000124784 E006 319.6182111 0.0011628985 5.291272e-14 1.564807e-12 6 7393108 7393303 196 + 2.548 2.344 -0.680
ENSG00000124784 E007 7.5372091 0.0025172600 4.732258e-01 6.122211e-01 6 7395021 7395052 32 + 0.949 0.862 -0.333
ENSG00000124784 E008 212.8086761 0.0002113855 3.214911e-05 1.898196e-04 6 7395053 7395143 91 + 2.346 2.236 -0.367
ENSG00000124784 E009 149.9672750 0.0020119832 3.666795e-02 8.484333e-02 6 7396703 7396751 49 + 2.186 2.109 -0.259
ENSG00000124784 E010 144.9145868 0.0003307890 3.819536e-04 1.705012e-03 6 7396752 7396772 21 + 2.182 2.068 -0.384
ENSG00000124784 E011 171.0501871 0.0010205685 4.791255e-02 1.054704e-01 6 7398698 7398740 43 + 2.238 2.175 -0.210
ENSG00000124784 E012 239.3238532 0.0001923218 1.096228e-01 2.050119e-01 6 7400958 7401050 93 + 2.374 2.336 -0.128
ENSG00000124784 E013 258.4277970 0.0025967765 3.467735e-01 4.909147e-01 6 7402603 7402715 113 + 2.404 2.375 -0.096
ENSG00000124784 E014 8.4043419 0.0022916990 7.919250e-01 8.669070e-01 6 7402716 7402816 101 + 0.970 0.940 -0.111
ENSG00000124784 E015 233.2720951 0.0023325322 7.911749e-01 8.664424e-01 6 7402817 7402897 81 + 2.347 2.356 0.031
ENSG00000124784 E016 0.7728905 0.0145222129 5.803501e-01 7.051117e-01 6 7403934 7403940 7 + 0.274 0.171 -0.862
ENSG00000124784 E017 260.1966648 0.0025585634 1.956909e-01 3.208233e-01 6 7403941 7404027 87 + 2.382 2.426 0.144
ENSG00000124784 E018 319.9244303 0.0002055030 5.777825e-01 7.029846e-01 6 7404418 7404555 138 + 2.482 2.495 0.041
ENSG00000124784 E019 279.4088467 0.0011094771 8.551754e-01 9.104341e-01 6 7404918 7405021 104 + 2.430 2.425 -0.017
ENSG00000124784 E020 1.4811342 0.0109241655 8.968452e-01 9.381036e-01 6 7405022 7405184 163 + 0.365 0.389 0.139
ENSG00000124784 E021 298.6391283 0.0002190877 8.909686e-01 9.343711e-01 6 7405249 7405355 107 + 2.456 2.460 0.012
ENSG00000124784 E022 0.4482035 0.0275729750 2.938800e-01 4.349381e-01 6 7410378 7410385 8 + 0.220 0.001 -8.821
ENSG00000124784 E023 273.1220129 0.0001807729 4.069236e-01 5.505557e-01 6 7410386 7410451 66 + 2.413 2.432 0.064
ENSG00000124784 E024 304.6060963 0.0001550593 4.196777e-04 1.849724e-03 6 7411332 7411451 120 + 2.439 2.514 0.250
ENSG00000124784 E025 1.9510085 0.0071690475 5.155837e-01 6.502356e-01 6 7411452 7411567 116 + 0.504 0.389 -0.600
ENSG00000124784 E026 188.7685012 0.0001932913 3.466861e-06 2.560471e-05 6 7412889 7412942 54 + 2.212 2.336 0.414
ENSG00000124784 E027 102.4848539 0.0002829279 5.222348e-06 3.699642e-05 6 7414238 7414253 16 + 1.932 2.095 0.549
ENSG00000124784 E028 269.1733140 0.0001548613 6.014911e-08 6.375933e-07 6 7414254 7414390 137 + 2.366 2.487 0.403
ENSG00000124784 E029 444.1742802 0.0064220248 5.922880e-07 5.165839e-06 6 7417331 7418037 707 + 2.548 2.750 0.674