ENSG00000124782

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334984 ENSG00000124782 HEK293_OSMI2_2hA HEK293_TMG_2hB RREB1 protein_coding protein_coding 6.313987 5.016426 7.410981 0.4223383 0.2938283 0.5620769 0.2574286 0.5014131 0.07969782 0.2790606 0.04055139 -2.5113442 0.04948333 0.10830000 0.0110000 -0.09730000 5.200738e-01 1.241429e-17 FALSE TRUE
ENST00000349384 ENSG00000124782 HEK293_OSMI2_2hA HEK293_TMG_2hB RREB1 protein_coding protein_coding 6.313987 5.016426 7.410981 0.4223383 0.2938283 0.5620769 2.1340667 2.2893538 2.23730476 0.1042946 0.17099993 -0.0330327 0.34355000 0.46023333 0.3036667 -0.15656667 3.602052e-02 1.241429e-17 FALSE TRUE
ENST00000379938 ENSG00000124782 HEK293_OSMI2_2hA HEK293_TMG_2hB RREB1 protein_coding protein_coding 6.313987 5.016426 7.410981 0.4223383 0.2938283 0.5620769 1.8189353 1.5469809 2.16457094 0.3015141 0.26112977 0.4819795 0.28984583 0.30360000 0.2908667 -0.01273333 9.582677e-01 1.241429e-17 FALSE TRUE
ENST00000471433 ENSG00000124782 HEK293_OSMI2_2hA HEK293_TMG_2hB RREB1 protein_coding protein_coding 6.313987 5.016426 7.410981 0.4223383 0.2938283 0.5620769 0.3294615 0.0000000 1.26999764 0.0000000 0.03778738 6.9999973 0.04420000 0.00000000 0.1716667 0.17166667 1.241429e-17 1.241429e-17 FALSE FALSE
ENST00000491191 ENSG00000124782 HEK293_OSMI2_2hA HEK293_TMG_2hB RREB1 protein_coding protein_coding 6.313987 5.016426 7.410981 0.4223383 0.2938283 0.5620769 0.9233829 0.1450226 1.28925491 0.0606383 0.35702855 3.0671336 0.13652917 0.02736667 0.1705333 0.14316667 8.915536e-03 1.241429e-17 FALSE FALSE
MSTRG.27595.2 ENSG00000124782 HEK293_OSMI2_2hA HEK293_TMG_2hB RREB1 protein_coding   6.313987 5.016426 7.410981 0.4223383 0.2938283 0.5620769 0.5352668 0.4535321 0.00000000 0.1747705 0.00000000 -5.5345974 0.08967917 0.08553333 0.0000000 -0.08553333 1.507977e-04 1.241429e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124782 E001 0.2214452 0.0378440578 4.425137e-01   6 7107597 7107675 79 + 0.000 0.154 10.202
ENSG00000124782 E002 0.9557277 0.0140815644 1.178546e-01 2.168553e-01 6 7107676 7107768 93 + 0.351 0.154 -1.548
ENSG00000124782 E003 0.0000000       6 7107769 7107798 30 +      
ENSG00000124782 E004 0.2987644 0.0290785164 2.288511e-01   6 7107799 7107820 22 + 0.176 0.000 -12.908
ENSG00000124782 E005 14.3915507 0.0223686993 1.586008e-03 5.913376e-03 6 7107821 7107960 140 + 1.242 1.054 -0.674
ENSG00000124782 E006 16.1751717 0.0013518772 3.036798e-03 1.037365e-02 6 7107961 7108025 65 + 1.254 1.177 -0.270
ENSG00000124782 E007 12.8250540 0.0013715590 5.643132e-03 1.766627e-02 6 7108026 7108030 5 + 1.167 1.081 -0.308
ENSG00000124782 E008 15.0689621 0.0013195433 1.951888e-03 7.077116e-03 6 7108031 7108060 30 + 1.235 1.139 -0.343
ENSG00000124782 E009 1.7005176 0.0109224482 1.788497e-01 2.996944e-01 6 7108061 7108064 4 + 0.476 0.357 -0.643
ENSG00000124782 E010 1.3652346 0.0733241681 1.584008e-01 2.729962e-01 6 7108632 7108702 71 + 0.438 0.267 -1.040
ENSG00000124782 E011 0.0000000       6 7139245 7139298 54 +      
ENSG00000124782 E012 0.1472490 0.0427074715 5.351118e-01   6 7140648 7140808 161 + 0.097 0.000 -11.841
ENSG00000124782 E013 30.9488496 0.0006827504 4.162960e-10 6.615723e-09 6 7176655 7176773 119 + 1.572 1.348 -0.773
ENSG00000124782 E014 25.4697254 0.0009931983 4.490190e-06 3.230983e-05 6 7181124 7181158 35 + 1.464 1.322 -0.492
ENSG00000124782 E015 29.4142806 0.0007137579 3.145370e-08 3.525088e-07 6 7181159 7181246 88 + 1.539 1.356 -0.631
ENSG00000124782 E016 1.6443055 0.0882789060 1.503093e-02 4.055726e-02 6 7181247 7181289 43 + 0.544 0.153 -2.561
ENSG00000124782 E017 6.2761147 0.0557135251 1.849609e-04 8.990468e-04 6 7181290 7181869 580 + 0.999 0.496 -2.076
ENSG00000124782 E018 39.9873304 0.0191265744 6.340046e-04 2.658542e-03 6 7181870 7182082 213 + 1.640 1.537 -0.350
ENSG00000124782 E019 26.7266439 0.0008312349 1.133227e-05 7.435544e-05 6 7187434 7187523 90 + 1.475 1.356 -0.412
ENSG00000124782 E020 35.9359952 0.0006285223 7.685856e-10 1.164198e-08 6 7189159 7189322 164 + 1.624 1.437 -0.639
ENSG00000124782 E021 36.7876263 0.0006482182 1.908433e-09 2.682696e-08 6 7210804 7210948 145 + 1.634 1.463 -0.584
ENSG00000124782 E022 42.3789610 0.0016130622 1.336172e-05 8.620251e-05 6 7211573 7211709 137 + 1.651 1.590 -0.209
ENSG00000124782 E023 3.4623516 0.0047736339 1.323261e-02 3.645573e-02 6 7211710 7219091 7382 + 0.351 0.868 2.358
ENSG00000124782 E024 46.7053452 0.0005634903 3.335945e-05 1.961102e-04 6 7226467 7226656 190 + 1.684 1.655 -0.097
ENSG00000124782 E025 260.4800620 0.0019717452 6.752708e-11 1.226069e-09 6 7228997 7231907 2911 + 2.401 2.416 0.050
ENSG00000124782 E026 18.1887441 0.0026833811 4.148561e-02 9.378221e-02 6 7240438 7240602 165 + 1.266 1.276 0.037
ENSG00000124782 E027 107.0573489 0.0008114273 3.932855e-02 8.978341e-02 6 7246424 7247221 798 + 1.970 2.085 0.385
ENSG00000124782 E028 652.7025202 0.0143723410 3.836076e-16 1.530286e-14 6 7248511 7251980 3470 + 2.547 3.023 1.585