ENSG00000124571

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265351 ENSG00000124571 HEK293_OSMI2_2hA HEK293_TMG_2hB XPO5 protein_coding protein_coding 70.82994 63.19972 72.63904 8.136278 0.3556109 0.2007974 49.576731 48.996197 43.91522892 5.1567749 0.65721978 -0.1579144 0.70490417 0.78076667 0.60453333 -0.17623333 2.304660e-03 4.724561e-08 FALSE TRUE
ENST00000450462 ENSG00000124571 HEK293_OSMI2_2hA HEK293_TMG_2hB XPO5 protein_coding retained_intron 70.82994 63.19972 72.63904 8.136278 0.3556109 0.2007974 4.381496 1.548425 6.33101652 0.0695166 0.62063491 2.0246255 0.06087917 0.02526667 0.08710000 0.06183333 4.724561e-08 4.724561e-08 FALSE FALSE
ENST00000486936 ENSG00000124571 HEK293_OSMI2_2hA HEK293_TMG_2hB XPO5 protein_coding nonsense_mediated_decay 70.82994 63.19972 72.63904 8.136278 0.3556109 0.2007974 1.493449 5.483032 0.07144391 3.6759702 0.07144391 -6.0756521 0.02233333 0.07973333 0.00100000 -0.07873333 8.829518e-03 4.724561e-08 FALSE FALSE
ENST00000488195 ENSG00000124571 HEK293_OSMI2_2hA HEK293_TMG_2hB XPO5 protein_coding retained_intron 70.82994 63.19972 72.63904 8.136278 0.3556109 0.2007974 5.393720 3.141625 6.35799056 0.1989883 0.77214936 1.0147424 0.07612083 0.05143333 0.08763333 0.03620000 1.172992e-01 4.724561e-08 FALSE FALSE
MSTRG.28337.4 ENSG00000124571 HEK293_OSMI2_2hA HEK293_TMG_2hB XPO5 protein_coding   70.82994 63.19972 72.63904 8.136278 0.3556109 0.2007974 6.607425 1.455583 12.53978545 1.4555827 0.46714571 3.0981164 0.08801667 0.02256667 0.17263333 0.15006667 5.697466e-02 4.724561e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124571 E001 10.6469529 0.0017258756 7.604794e-02 1.531916e-01 6 43522334 43522336 3 - 0.960 1.141 0.660
ENSG00000124571 E002 291.0203629 0.0008259434 1.231346e-34 2.949114e-32 6 43522337 43522564 228 - 2.262 2.580 1.059
ENSG00000124571 E003 1690.7425661 0.0065163629 1.039059e-05 6.881057e-05 6 43522565 43523663 1099 - 3.129 3.286 0.522
ENSG00000124571 E004 705.0542469 0.0003888176 5.659949e-15 1.932874e-13 6 43523664 43524005 342 - 2.775 2.899 0.413
ENSG00000124571 E005 276.2469127 0.0014077066 2.248136e-06 1.729413e-05 6 43524471 43524476 6 - 2.365 2.497 0.439
ENSG00000124571 E006 429.0037881 0.0019253849 2.027084e-08 2.361051e-07 6 43524477 43524533 57 - 2.542 2.694 0.505
ENSG00000124571 E007 519.7290943 0.0026821606 2.211359e-08 2.557915e-07 6 43524534 43524635 102 - 2.618 2.778 0.532
ENSG00000124571 E008 635.8377509 0.0035087929 1.462343e-06 1.172542e-05 6 43524831 43524968 138 - 2.712 2.861 0.496
ENSG00000124571 E009 40.9845775 0.0056689909 3.851029e-04 1.717151e-03 6 43524969 43525106 138 - 1.739 1.504 -0.799
ENSG00000124571 E010 560.0553059 0.0028045413 6.846456e-06 4.726135e-05 6 43525107 43525214 108 - 2.670 2.800 0.436
ENSG00000124571 E011 13.7135418 0.0073249099 7.416607e-03 2.230180e-02 6 43525215 43525838 624 - 1.300 1.041 -0.923
ENSG00000124571 E012 556.6004683 0.0032884814 2.580930e-04 1.208894e-03 6 43525839 43525921 83 - 2.678 2.791 0.375
ENSG00000124571 E013 6.7200776 0.0024796962 5.811707e-01 7.057579e-01 6 43525922 43525954 33 - 0.926 0.861 -0.250
ENSG00000124571 E014 18.7861676 0.0009282963 4.691525e-07 4.173336e-06 6 43525955 43526625 671 - 1.478 1.078 -1.409
ENSG00000124571 E015 432.6731466 0.0041232052 7.655662e-03 2.291509e-02 6 43526685 43526747 63 - 2.580 2.676 0.317
ENSG00000124571 E016 45.6296443 0.0058860388 2.066660e-12 4.815774e-11 6 43526748 43527064 317 - 1.868 1.404 -1.578
ENSG00000124571 E017 54.9619533 0.0004134942 2.253104e-36 6.010437e-34 6 43527186 43527633 448 - 1.996 1.348 -2.204
ENSG00000124571 E018 410.2543669 0.0025243803 1.418393e-03 5.367979e-03 6 43527634 43527670 37 - 2.559 2.653 0.316
ENSG00000124571 E019 470.3382278 0.0009869520 3.667025e-06 2.692349e-05 6 43527671 43527731 61 - 2.614 2.717 0.342
ENSG00000124571 E020 397.9856250 0.0021651036 5.635950e-03 1.764641e-02 6 43528159 43528205 47 - 2.555 2.635 0.268
ENSG00000124571 E021 472.7608123 0.0005309679 5.255461e-07 4.628691e-06 6 43528828 43528925 98 - 2.620 2.718 0.324
ENSG00000124571 E022 62.3358561 0.0005692751 3.280353e-01 4.714907e-01 6 43528926 43528928 3 - 1.775 1.818 0.147
ENSG00000124571 E023 6.4476467 0.0026445160 6.662488e-05 3.638059e-04 6 43530654 43530687 34 - 1.085 0.582 -1.986
ENSG00000124571 E024 515.6086771 0.0001492897 7.366386e-06 5.044605e-05 6 43530688 43530824 137 - 2.672 2.744 0.242
ENSG00000124571 E025 447.3252934 0.0005308540 1.237746e-02 3.443986e-02 6 43531479 43531575 97 - 2.624 2.671 0.155
ENSG00000124571 E026 3.1794974 0.0082010451 6.067050e-01 7.267915e-01 6 43533353 43533906 554 - 0.569 0.648 0.348
ENSG00000124571 E027 431.6557222 0.0001293556 2.768180e-03 9.577611e-03 6 43533907 43534007 101 - 2.608 2.660 0.174
ENSG00000124571 E028 554.3821008 0.0012451054 2.888101e-01 4.294511e-01 6 43546571 43546752 182 - 2.733 2.752 0.063
ENSG00000124571 E029 1.8102014 0.0085113424 3.103943e-01 4.527856e-01 6 43547316 43547453 138 - 0.527 0.353 -0.918
ENSG00000124571 E030 396.5510419 0.0013174901 8.450046e-02 1.665975e-01 6 43547608 43547685 78 - 2.625 2.579 -0.154
ENSG00000124571 E031 283.7028792 0.0002770970 1.950024e-01 3.199879e-01 6 43547686 43547707 22 - 2.472 2.443 -0.098
ENSG00000124571 E032 626.8000141 0.0007745936 4.333503e-05 2.478286e-04 6 43548261 43548460 200 - 2.842 2.761 -0.269
ENSG00000124571 E033 0.3697384 0.0253615075 2.187181e-01 3.488770e-01 6 43548461 43548470 10 - 0.000 0.211 9.502
ENSG00000124571 E034 282.2784071 0.0001895244 4.878053e-04 2.113559e-03 6 43549489 43549533 45 - 2.495 2.419 -0.253
ENSG00000124571 E035 307.9187023 0.0001809274 1.926285e-04 9.323444e-04 6 43549534 43549578 45 - 2.533 2.454 -0.261
ENSG00000124571 E036 259.4605726 0.0002545291 8.206299e-03 2.430689e-02 6 43549893 43549934 42 - 2.450 2.389 -0.204
ENSG00000124571 E037 260.2838129 0.0019664287 2.754556e-01 4.147630e-01 6 43551298 43551323 26 - 2.438 2.402 -0.122
ENSG00000124571 E038 400.0135831 0.0001692567 2.423999e-02 6.030536e-02 6 43551324 43551453 130 - 2.629 2.587 -0.139
ENSG00000124571 E039 377.5658387 0.0013041530 3.549479e-01 4.992936e-01 6 43553373 43553503 131 - 2.593 2.566 -0.089
ENSG00000124571 E040 425.1057495 0.0058355639 5.411629e-03 1.704604e-02 6 43555836 43555964 129 - 2.690 2.572 -0.394
ENSG00000124571 E041 407.0959733 0.0097866350 3.626176e-03 1.208515e-02 6 43558501 43558591 91 - 2.687 2.536 -0.504
ENSG00000124571 E042 0.7373013 0.0973046801 7.852959e-01 8.623730e-01 6 43558920 43559062 143 - 0.224 0.284 0.452
ENSG00000124571 E043 477.1866578 0.0050106717 3.391985e-04 1.537213e-03 6 43560178 43560303 126 - 2.752 2.609 -0.479
ENSG00000124571 E044 362.3136606 0.0031569027 1.876340e-05 1.171264e-04 6 43560924 43561007 84 - 2.636 2.488 -0.492
ENSG00000124571 E045 311.2180296 0.0032039334 2.708686e-02 6.616968e-02 6 43562247 43562346 100 - 2.537 2.456 -0.270
ENSG00000124571 E046 287.3383720 0.0098177699 7.251861e-02 1.475442e-01 6 43565660 43565736 77 - 2.512 2.410 -0.341
ENSG00000124571 E047 451.9173634 0.0061527195 6.094040e-03 1.885787e-02 6 43567169 43567354 186 - 2.718 2.596 -0.404
ENSG00000124571 E048 252.4096361 0.0010863217 3.044891e-09 4.125334e-08 6 43568711 43568734 24 - 2.489 2.326 -0.545
ENSG00000124571 E049 192.3831200 0.0015355686 3.082601e-07 2.844844e-06 6 43568735 43568737 3 - 2.372 2.208 -0.547
ENSG00000124571 E050 495.6216927 0.0067708782 1.975561e-06 1.538662e-05 6 43570502 43570684 183 - 2.799 2.590 -0.698
ENSG00000124571 E051 340.8007222 0.0052516102 3.887288e-09 5.166877e-08 6 43570857 43570929 73 - 2.653 2.409 -0.811
ENSG00000124571 E052 369.1074802 0.0068779610 1.660654e-09 2.363148e-08 6 43570930 43570994 65 - 2.701 2.423 -0.926
ENSG00000124571 E053 341.5121107 0.0041063667 5.703074e-13 1.454342e-11 6 43572506 43572578 73 - 2.666 2.392 -0.915
ENSG00000124571 E054 2.6561302 0.1276882718 2.384726e-01 3.723680e-01 6 43573398 43573479 82 - 0.674 0.416 -1.212
ENSG00000124571 E055 357.0677848 0.0076237063 1.449904e-07 1.427873e-06 6 43573480 43573601 122 - 2.678 2.420 -0.857
ENSG00000124571 E056 285.1794415 0.0132023995 2.023744e-04 9.740656e-04 6 43575760 43576054 295 - 2.568 2.339 -0.764