ENSG00000124570

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380529 ENSG00000124570 HEK293_OSMI2_2hA HEK293_TMG_2hB SERPINB6 protein_coding protein_coding 45.2722 65.78379 44.1184 9.154547 1.723667 -0.5762438 3.47951 3.12885 6.083426 0.04880834 0.7469787 0.9570176 0.0773875 0.04913333 0.1388000 0.08966667 0.0001806183 3.455152e-05 FALSE TRUE
ENST00000380539 ENSG00000124570 HEK293_OSMI2_2hA HEK293_TMG_2hB SERPINB6 protein_coding protein_coding 45.2722 65.78379 44.1184 9.154547 1.723667 -0.5762438 28.68466 44.39811 25.156977 6.09113332 2.2073054 -0.8192913 0.6286583 0.67516667 0.5681333 -0.10703333 0.0277254238 3.455152e-05 FALSE TRUE
ENST00000380546 ENSG00000124570 HEK293_OSMI2_2hA HEK293_TMG_2hB SERPINB6 protein_coding protein_coding 45.2722 65.78379 44.1184 9.154547 1.723667 -0.5762438 5.44608 10.47993 4.466243 2.87184824 0.3153385 -1.2286443 0.1137417 0.15393333 0.1015667 -0.05236667 0.1566939887 3.455152e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124570 E001 1.919493 0.0535605324 4.435872e-03 1.436002e-02 6 2948159 2948159 1 - 0.000 0.595 11.514
ENSG00000124570 E002 1.919493 0.0535605324 4.435872e-03 1.436002e-02 6 2948160 2948161 2 - 0.000 0.595 13.392
ENSG00000124570 E003 2.066742 0.0525644199 3.202329e-02 7.590607e-02 6 2948162 2948162 1 - 0.154 0.595 2.792
ENSG00000124570 E004 4.204877 0.0041508023 5.385124e-01 6.699333e-01 6 2948163 2948163 1 - 0.643 0.739 0.402
ENSG00000124570 E005 9.049667 0.0224001732 9.239763e-01 9.561200e-01 6 2948164 2948169 6 - 0.996 0.993 -0.010
ENSG00000124570 E006 9.343133 0.0347886850 8.643404e-01 9.165423e-01 6 2948170 2948170 1 - 1.014 1.001 -0.047
ENSG00000124570 E007 12.617351 0.0238467208 9.373717e-01 9.646317e-01 6 2948171 2948174 4 - 1.124 1.122 -0.005
ENSG00000124570 E008 51.539454 0.0057837483 9.690273e-01 9.846310e-01 6 2948175 2948192 18 - 1.697 1.707 0.034
ENSG00000124570 E009 54.167407 0.0052884276 9.801111e-01 9.915932e-01 6 2948193 2948195 3 - 1.719 1.728 0.031
ENSG00000124570 E010 106.161879 0.0004053858 9.980984e-02 1.901918e-01 6 2948196 2948216 21 - 1.967 2.034 0.224
ENSG00000124570 E011 161.582929 0.0002324641 4.461692e-03 1.443374e-02 6 2948217 2948244 28 - 2.131 2.222 0.305
ENSG00000124570 E012 921.046924 0.0011555917 6.678620e-05 3.645607e-04 6 2948245 2948699 455 - 2.890 2.965 0.251
ENSG00000124570 E013 403.288078 0.0004712589 8.240601e-02 1.633051e-01 6 2948914 2948965 52 - 2.560 2.602 0.138
ENSG00000124570 E014 521.715570 0.0001620308 1.263529e-01 2.290711e-01 6 2948966 2949069 104 - 2.679 2.710 0.104
ENSG00000124570 E015 526.685535 0.0001482049 8.116897e-01 8.804944e-01 6 2953044 2953186 143 - 2.702 2.704 0.006
ENSG00000124570 E016 459.436924 0.0001340037 4.668119e-01 6.063540e-01 6 2954592 2954702 111 - 2.648 2.641 -0.022
ENSG00000124570 E017 240.665444 0.0001882452 4.910632e-01 6.283763e-01 6 2954703 2954709 7 - 2.370 2.359 -0.035
ENSG00000124570 E018 4.035833 0.0075000325 7.266223e-01 8.195883e-01 6 2954710 2955523 814 - 0.720 0.675 -0.184
ENSG00000124570 E019 355.502427 0.0003306985 2.521690e-01 3.884904e-01 6 2955524 2955604 81 - 2.543 2.524 -0.065
ENSG00000124570 E020 280.744299 0.0001946859 6.028177e-01 7.237182e-01 6 2955605 2955651 47 - 2.433 2.427 -0.020
ENSG00000124570 E021 162.723968 0.0002298139 7.542832e-01 8.399759e-01 6 2955652 2955654 3 - 2.196 2.193 -0.010
ENSG00000124570 E022 179.759902 0.0002221091 5.518453e-01 6.812598e-01 6 2955655 2955670 16 - 2.244 2.234 -0.035
ENSG00000124570 E023 5.815278 0.0031150738 3.481828e-01 4.924058e-01 6 2955671 2956504 834 - 0.892 0.777 -0.445
ENSG00000124570 E024 2.684039 0.1182853124 9.372890e-01 9.646007e-01 6 2956505 2956695 191 - 0.549 0.544 -0.025
ENSG00000124570 E025 1.886273 0.0077057684 3.500576e-01 4.942418e-01 6 2956696 2956814 119 - 0.550 0.397 -0.768
ENSG00000124570 E026 3.467650 0.0056897870 5.291202e-01 6.619488e-01 6 2956815 2958169 1355 - 0.550 0.653 0.457
ENSG00000124570 E027 321.585375 0.0001677263 3.132305e-01 4.557787e-01 6 2959168 2959297 130 - 2.498 2.483 -0.051
ENSG00000124570 E028 186.040608 0.0007130790 1.680580e-01 2.856741e-01 6 2959298 2959342 45 - 2.274 2.237 -0.124
ENSG00000124570 E029 14.586226 0.0169081773 4.123898e-01 5.559454e-01 6 2959343 2960260 918 - 1.223 1.131 -0.328
ENSG00000124570 E030 2.582045 0.0446073953 2.662235e-01 4.043910e-01 6 2960261 2960378 118 - 0.643 0.442 -0.944
ENSG00000124570 E031 6.867592 0.1206243856 3.231645e-01 4.664966e-01 6 2960379 2960969 591 - 0.998 0.795 -0.772
ENSG00000124570 E032 3.668474 0.0566800506 1.807121e-01 3.020803e-01 6 2960970 2961096 127 - 0.785 0.546 -1.021
ENSG00000124570 E033 3.292288 0.0236772757 6.399183e-01 7.532424e-01 6 2961097 2961327 231 - 0.550 0.629 0.352
ENSG00000124570 E034 3.472021 0.0284640475 9.374617e-02 1.809782e-01 6 2961894 2962029 136 - 0.785 0.513 -1.176
ENSG00000124570 E035 2.767917 0.0055360413 6.949536e-02 1.425228e-01 6 2962030 2962139 110 - 0.720 0.439 -1.280
ENSG00000124570 E036 6.201216 0.0062077045 4.519511e-03 1.459902e-02 6 2963395 2964005 611 - 1.032 0.677 -1.381
ENSG00000124570 E037 2.328235 0.0062427695 4.491884e-03 1.452000e-02 6 2966400 2966590 191 - 0.753 0.301 -2.226
ENSG00000124570 E038 13.456633 0.0082784820 5.243586e-19 2.984921e-17 6 2966591 2968778 2188 - 1.527 0.574 -3.572
ENSG00000124570 E039 5.939828 0.0027947938 2.182973e-02 5.532174e-02 6 2968779 2968798 20 - 0.996 0.719 -1.072
ENSG00000124570 E040 10.055372 0.0065996472 4.415135e-03 1.430560e-02 6 2968799 2968913 115 - 1.200 0.902 -1.091
ENSG00000124570 E041 3.972071 0.0046108491 2.086491e-02 5.330090e-02 6 2968914 2969102 189 - 0.867 0.543 -1.351
ENSG00000124570 E042 11.081965 0.0087810481 1.174153e-07 1.177366e-06 6 2969103 2970695 1593 - 1.347 0.778 -2.084
ENSG00000124570 E043 6.205165 0.0045409535 1.318625e-01 2.367056e-01 6 2970696 2970757 62 - 0.957 0.777 -0.694
ENSG00000124570 E044 5.756134 0.0028120078 9.641974e-03 2.788547e-02 6 2970758 2970824 67 - 0.996 0.676 -1.252
ENSG00000124570 E045 8.584305 0.0022214413 3.666687e-04 1.645332e-03 6 2970825 2971116 292 - 1.176 0.795 -1.418
ENSG00000124570 E046 26.399761 0.0269054676 1.828324e-10 3.083235e-09 6 2971117 2971247 131 - 1.740 1.054 -2.383
ENSG00000124570 E047 34.317495 0.0006832003 5.377621e-08 5.757399e-07 6 2971248 2971490 243 - 1.712 1.397 -1.077
ENSG00000124570 E048 20.564449 0.0009149089 6.881070e-02 1.414034e-01 6 2971491 2971532 42 - 1.212 1.365 0.538
ENSG00000124570 E049 94.884531 0.0051343000 6.950659e-01 7.957537e-01 6 2971533 2971591 59 - 1.946 1.960 0.047
ENSG00000124570 E050 89.408920 0.0074745615 9.574630e-01 9.773350e-01 6 2971592 2972165 574 - 1.938 1.928 -0.034