ENSG00000124532

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378353 ENSG00000124532 HEK293_OSMI2_2hA HEK293_TMG_2hB MRS2 protein_coding protein_coding 29.87594 10.4475 49.30346 1.162336 1.086779 2.237444 10.083852 5.5693009 13.655979 1.06552366 1.17693199 1.292433 0.3992250 0.52446667 0.2766667 -0.24780000 0.0001510206 0.0001510206 FALSE TRUE
ENST00000378386 ENSG00000124532 HEK293_OSMI2_2hA HEK293_TMG_2hB MRS2 protein_coding protein_coding 29.87594 10.4475 49.30346 1.162336 1.086779 2.237444 4.895277 1.9029220 8.153241 0.37429733 0.07787424 2.093364 0.1772500 0.17886667 0.1655667 -0.01330000 0.7896891256 0.0001510206 FALSE TRUE
MSTRG.27727.11 ENSG00000124532 HEK293_OSMI2_2hA HEK293_TMG_2hB MRS2 protein_coding   29.87594 10.4475 49.30346 1.162336 1.086779 2.237444 3.889922 0.6150523 7.700141 0.12283307 0.24459717 3.624709 0.1076542 0.06233333 0.1561000 0.09376667 0.0080808785 0.0001510206 FALSE TRUE
MSTRG.27727.5 ENSG00000124532 HEK293_OSMI2_2hA HEK293_TMG_2hB MRS2 protein_coding   29.87594 10.4475 49.30346 1.162336 1.086779 2.237444 6.557235 1.0017064 12.704793 0.07538106 1.36840730 3.651645 0.1604000 0.09953333 0.2574667 0.15793333 0.0008860332 0.0001510206 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124532 E001 0.0000000       6 24402908 24402909 2 +      
ENSG00000124532 E002 0.7845438 0.2963227327 3.708134e-01 5.152289e-01 6 24402910 24402930 21 + 0.178 0.352 1.303
ENSG00000124532 E003 1.7402716 0.0086727648 6.362144e-01 7.502865e-01 6 24402931 24402935 5 + 0.369 0.462 0.499
ENSG00000124532 E004 1.7402716 0.0086727648 6.362144e-01 7.502865e-01 6 24402936 24402936 1 + 0.369 0.462 0.499
ENSG00000124532 E005 3.1377715 0.0108781255 3.645896e-01 5.089478e-01 6 24402937 24402938 2 + 0.525 0.680 0.692
ENSG00000124532 E006 3.7591466 0.0053511363 3.634731e-01 5.078766e-01 6 24402939 24402940 2 + 0.585 0.734 0.634
ENSG00000124532 E007 21.3276711 0.0188517489 2.017176e-01 3.283200e-01 6 24402941 24402953 13 + 1.318 1.172 -0.516
ENSG00000124532 E008 174.6128787 0.0016343637 1.518877e-01 2.642374e-01 6 24402954 24403191 238 + 2.191 2.142 -0.165
ENSG00000124532 E009 100.1223837 0.0009432879 5.543341e-01 6.833258e-01 6 24403192 24403236 45 + 1.946 1.926 -0.068
ENSG00000124532 E010 171.5349388 0.0002041271 6.220759e-02 1.303597e-01 6 24405168 24405241 74 + 2.186 2.132 -0.180
ENSG00000124532 E011 155.3056732 0.0002311204 1.003126e-03 3.969156e-03 6 24408408 24408444 37 + 2.155 2.047 -0.362
ENSG00000124532 E012 155.1988138 0.0002558592 1.398281e-02 3.818600e-02 6 24409461 24409493 33 + 2.149 2.071 -0.261
ENSG00000124532 E013 210.8752718 0.0002253719 3.736136e-03 1.239992e-02 6 24409494 24409573 80 + 2.282 2.203 -0.264
ENSG00000124532 E014 0.6653823 0.0170851436 8.574553e-01 9.119724e-01 6 24410727 24410799 73 + 0.177 0.213 0.331
ENSG00000124532 E015 164.6679967 0.0002079409 4.389302e-01 5.807290e-01 6 24412222 24412285 64 + 2.159 2.140 -0.063
ENSG00000124532 E016 220.3123154 0.0002087298 8.509515e-01 9.075771e-01 6 24412286 24412395 110 + 2.279 2.291 0.040
ENSG00000124532 E017 8.8927268 0.0019127372 6.006179e-01 7.218257e-01 6 24415016 24415032 17 + 0.923 0.993 0.262
ENSG00000124532 E018 243.9488312 0.0001799309 3.762335e-01 5.205842e-01 6 24415033 24415163 131 + 2.319 2.349 0.100
ENSG00000124532 E019 106.9890867 0.0003074795 4.374110e-01 5.793704e-01 6 24416397 24416410 14 + 1.976 1.951 -0.084
ENSG00000124532 E020 209.0926518 0.0002235701 8.681863e-01 9.192261e-01 6 24416411 24416513 103 + 2.259 2.261 0.005
ENSG00000124532 E021 254.2483220 0.0004341105 1.439635e-01 2.534072e-01 6 24418084 24418236 153 + 2.351 2.317 -0.113
ENSG00000124532 E022 8.4717676 0.0304288937 9.611488e-01 9.795404e-01 6 24418371 24418460 90 + 0.914 0.903 -0.040
ENSG00000124532 E023 246.2094264 0.0002012258 1.914578e-01 3.155710e-01 6 24418461 24418578 118 + 2.335 2.306 -0.095
ENSG00000124532 E024 22.7630670 0.0011244761 1.399944e-05 8.991384e-05 6 24418579 24419241 663 + 1.383 0.934 -1.609
ENSG00000124532 E025 133.6706029 0.0002445551 8.515166e-01 9.079295e-01 6 24422937 24422964 28 + 2.061 2.074 0.044
ENSG00000124532 E026 192.6381893 0.0002790756 1.809239e-01 3.023723e-01 6 24422965 24423050 86 + 2.212 2.258 0.154
ENSG00000124532 E027 79.0153201 0.0003969509 8.994995e-21 6.318409e-19 6 24423051 24423476 426 + 1.710 2.105 1.328
ENSG00000124532 E028 889.8219696 0.0011083755 3.070740e-03 1.047449e-02 6 24423584 24429000 5417 + 2.871 2.927 0.185
ENSG00000124532 E029 3.5387059 0.0063097614 5.012011e-01 6.373580e-01 6 24430263 24430453 191 + 0.566 0.681 0.501
ENSG00000124532 E030 4.0943279 0.0038278898 4.876198e-02 1.069637e-01 6 24437132 24437267 136 + 0.566 0.864 1.235