ENSG00000124508

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356709 ENSG00000124508 HEK293_OSMI2_2hA HEK293_TMG_2hB BTN2A2 protein_coding protein_coding 8.572369 5.97206 8.81359 0.8627687 0.4428308 0.5607233 1.7079969 1.1906313 1.8505336 0.19912822 0.40884156 0.6319232 0.19721667 0.21030000 0.2082667 -0.002033333 1.000000e+00 4.189252e-17 FALSE TRUE
ENST00000469230 ENSG00000124508 HEK293_OSMI2_2hA HEK293_TMG_2hB BTN2A2 protein_coding protein_coding 8.572369 5.97206 8.81359 0.8627687 0.4428308 0.5607233 0.2680866 0.8017105 0.1444431 0.16280709 0.08220788 -2.3938900 0.03734167 0.13330000 0.0161000 -0.117200000 7.040442e-03 4.189252e-17 FALSE TRUE
ENST00000482536 ENSG00000124508 HEK293_OSMI2_2hA HEK293_TMG_2hB BTN2A2 protein_coding protein_coding 8.572369 5.97206 8.81359 0.8627687 0.4428308 0.5607233 0.5203896 1.0317918 0.2142156 0.28144395 0.21421560 -2.2161084 0.06367500 0.16753333 0.0224000 -0.145133333 7.046488e-02 4.189252e-17 FALSE TRUE
ENST00000495632 ENSG00000124508 HEK293_OSMI2_2hA HEK293_TMG_2hB BTN2A2 protein_coding protein_coding 8.572369 5.97206 8.81359 0.8627687 0.4428308 0.5607233 1.0319473 0.6059117 1.1187769 0.07543928 0.11592856 0.8739650 0.11722083 0.10756667 0.1287333 0.021166667 7.751798e-01 4.189252e-17 FALSE FALSE
MSTRG.27798.14 ENSG00000124508 HEK293_OSMI2_2hA HEK293_TMG_2hB BTN2A2 protein_coding   8.572369 5.97206 8.81359 0.8627687 0.4428308 0.5607233 0.2335260 1.1107298 0.0000000 0.10691197 0.00000000 -6.8082946 0.03870833 0.19216667 0.0000000 -0.192166667 1.149432e-16 4.189252e-17 FALSE TRUE
MSTRG.27798.5 ENSG00000124508 HEK293_OSMI2_2hA HEK293_TMG_2hB BTN2A2 protein_coding   8.572369 5.97206 8.81359 0.8627687 0.4428308 0.5607233 0.9808418 0.0000000 1.6574940 0.00000000 0.22827328 7.3815377 0.10181667 0.00000000 0.1864000 0.186400000 4.189252e-17 4.189252e-17 FALSE TRUE
MSTRG.27798.6 ENSG00000124508 HEK293_OSMI2_2hA HEK293_TMG_2hB BTN2A2 protein_coding   8.572369 5.97206 8.81359 0.8627687 0.4428308 0.5607233 1.7077460 0.1862650 1.7081223 0.18626504 0.60206244 3.1299577 0.19928750 0.02446667 0.2012333 0.176766667 9.372985e-02 4.189252e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124508 E001 0.1482932 0.0411597534 3.864662e-01   6 26383096 26383100 5 + 0.000 0.135 9.095
ENSG00000124508 E002 0.1482932 0.0411597534 3.864662e-01   6 26383101 26383101 1 + 0.000 0.135 11.258
ENSG00000124508 E003 0.1482932 0.0411597534 3.864662e-01   6 26383102 26383104 3 + 0.000 0.135 11.258
ENSG00000124508 E004 0.4470576 0.0212346078 7.193831e-01 8.142379e-01 6 26383105 26383107 3 + 0.198 0.136 -0.656
ENSG00000124508 E005 0.7437457 0.0156267434 2.632142e-01 4.010903e-01 6 26383108 26383112 5 + 0.333 0.136 -1.655
ENSG00000124508 E006 3.5753553 0.0049016338 9.288300e-04 3.715300e-03 6 26383113 26383125 13 + 0.849 0.322 -2.462
ENSG00000124508 E007 4.5362799 0.0034692461 1.553348e-03 5.808981e-03 6 26383126 26383127 2 + 0.915 0.452 -1.976
ENSG00000124508 E008 10.6568711 0.0043790851 4.563134e-03 1.471943e-02 6 26383128 26383142 15 + 1.196 0.901 -1.081
ENSG00000124508 E009 16.3425962 0.0163862029 2.716985e-02 6.634162e-02 6 26383143 26383181 39 + 1.343 1.114 -0.809
ENSG00000124508 E010 9.9649585 0.0213416574 2.298562e-02 5.771754e-02 6 26383182 26383190 9 + 1.163 0.879 -1.045
ENSG00000124508 E011 10.1227149 0.0058832917 2.798736e-02 6.798637e-02 6 26383191 26383207 17 + 1.155 0.920 -0.858
ENSG00000124508 E012 10.3118061 0.0022066840 6.212671e-02 1.302176e-01 6 26383208 26383217 10 + 1.146 0.957 -0.688
ENSG00000124508 E013 12.3820738 0.0016491191 1.212108e-01 2.216615e-01 6 26383218 26383244 27 + 1.196 1.052 -0.520
ENSG00000124508 E014 12.2776058 0.0014808862 3.684872e-01 5.129003e-01 6 26383245 26383299 55 + 1.088 1.174 0.308
ENSG00000124508 E015 0.4482035 0.0276787765 1.335353e-01 2.390515e-01 6 26383300 26383313 14 + 0.271 0.000 -13.385
ENSG00000124508 E016 1.4340316 0.0240876402 9.784510e-01 9.906499e-01 6 26383433 26383652 220 + 0.388 0.392 0.023
ENSG00000124508 E017 4.2009162 0.0233390646 8.193258e-01 8.859168e-01 6 26383653 26383791 139 + 0.703 0.733 0.123
ENSG00000124508 E018 32.2975780 0.0007008057 3.486259e-02 8.138581e-02 6 26383792 26383915 124 + 1.586 1.460 -0.429
ENSG00000124508 E019 28.2361748 0.0007453480 2.590031e-03 9.035349e-03 6 26385015 26385142 128 + 1.555 1.362 -0.667
ENSG00000124508 E020 42.6452071 0.0009292891 9.192540e-01 9.529720e-01 6 26385143 26385362 220 + 1.644 1.639 -0.016
ENSG00000124508 E021 1.3391957 0.0923090864 7.465673e-01 8.342915e-01 6 26385363 26385559 197 + 0.334 0.393 0.347
ENSG00000124508 E022 44.5608211 0.0004901208 1.745749e-01 2.941442e-01 6 26388013 26388198 186 + 1.629 1.700 0.241
ENSG00000124508 E023 32.2820963 0.0006835817 1.938873e-01 3.186661e-01 6 26388199 26388294 96 + 1.492 1.572 0.274
ENSG00000124508 E024 39.6338477 0.0006032946 8.539474e-01 9.096371e-01 6 26390005 26390102 98 + 1.620 1.612 -0.026
ENSG00000124508 E025 47.9637833 0.0004689992 8.125001e-01 8.810809e-01 6 26390103 26390211 109 + 1.689 1.703 0.047
ENSG00000124508 E026 1.4091281 0.0095888042 1.745977e-01 2.941750e-01 6 26390212 26390686 475 + 0.480 0.239 -1.461
ENSG00000124508 E027 24.2957330 0.0008669707 1.539610e-01 2.670581e-01 6 26390687 26390707 21 + 1.361 1.460 0.345
ENSG00000124508 E028 3.4459740 0.0046172495 3.879041e-02 8.879456e-02 6 26390708 26390802 95 + 0.771 0.453 -1.419
ENSG00000124508 E029 23.1793569 0.0008880960 3.237054e-01 4.670389e-01 6 26390803 26390829 27 + 1.355 1.426 0.246
ENSG00000124508 E030 39.3161064 0.0006295373 8.429812e-03 2.486218e-02 6 26390830 26392221 1392 + 1.671 1.527 -0.491
ENSG00000124508 E031 14.9591323 0.0178440208 5.099101e-01 6.451847e-01 6 26392222 26392374 153 + 1.235 1.164 -0.251
ENSG00000124508 E032 39.1500981 0.0005466140 3.263245e-01 4.697802e-01 6 26392375 26392439 65 + 1.632 1.580 -0.176
ENSG00000124508 E033 101.4413103 0.0012788344 9.981916e-01 1.000000e+00 6 26392440 26392896 457 + 2.016 2.017 0.004
ENSG00000124508 E034 225.8474743 0.0008295739 6.115755e-06 4.269332e-05 6 26392897 26394297 1401 + 2.308 2.412 0.346
ENSG00000124508 E035 31.4153017 0.0007330339 9.110251e-05 4.802197e-04 6 26394298 26394874 577 + 1.382 1.624 0.830