ENSG00000124486

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324545 ENSG00000124486 HEK293_OSMI2_2hA HEK293_TMG_2hB USP9X protein_coding protein_coding 27.92722 16.7605 38.04702 0.9877271 0.7022689 1.182237 1.457407 0.7965456 2.4542293 0.008243437 0.1296033 1.611309 0.05096667 0.04783333 0.064633333 0.01680000 3.201855e-01 2.489747e-09 FALSE TRUE
ENST00000378308 ENSG00000124486 HEK293_OSMI2_2hA HEK293_TMG_2hB USP9X protein_coding protein_coding 27.92722 16.7605 38.04702 0.9877271 0.7022689 1.182237 12.709542 2.7017354 23.4148407 1.160176003 0.1574905 3.110751 0.39332083 0.15593333 0.615866667 0.45993333 1.975642e-05 2.489747e-09 FALSE TRUE
ENST00000485180 ENSG00000124486 HEK293_OSMI2_2hA HEK293_TMG_2hB USP9X protein_coding retained_intron 27.92722 16.7605 38.04702 0.9877271 0.7022689 1.182237 1.215135 2.1415760 0.3618127 0.589328250 0.1300200 -2.532746 0.06462500 0.12986667 0.009433333 -0.12043333 1.958144e-05 2.489747e-09 FALSE TRUE
MSTRG.34114.1 ENSG00000124486 HEK293_OSMI2_2hA HEK293_TMG_2hB USP9X protein_coding   27.92722 16.7605 38.04702 0.9877271 0.7022689 1.182237 2.123310 0.9127313 4.2817306 0.363252827 0.7752290 2.217577 0.06978333 0.05563333 0.112000000 0.05636667 3.970038e-01 2.489747e-09 FALSE TRUE
MSTRG.34114.15 ENSG00000124486 HEK293_OSMI2_2hA HEK293_TMG_2hB USP9X protein_coding   27.92722 16.7605 38.04702 0.9877271 0.7022689 1.182237 7.247267 9.7123552 3.3068135 0.822193843 1.4188832 -1.551508 0.31795417 0.57956667 0.086033333 -0.49353333 4.953259e-07 2.489747e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124486 E001 13.2144263 0.0525337009 9.689398e-01 9.845673e-01 X 41085431 41085444 14 + 1.108 1.130 0.080
ENSG00000124486 E002 64.4329751 0.0030608035 3.007148e-12 6.825149e-11 X 41085445 41085628 184 + 1.873 1.472 -1.363
ENSG00000124486 E003 42.6477756 0.0006001182 5.142098e-17 2.287259e-15 X 41085629 41085655 27 + 1.723 1.137 -2.029
ENSG00000124486 E004 57.3840599 0.0218882521 7.491410e-09 9.448902e-08 X 41085656 41085708 53 + 1.843 1.314 -1.808
ENSG00000124486 E005 47.7136659 0.0283689807 6.964206e-07 5.983438e-06 X 41085709 41085714 6 + 1.761 1.266 -1.701
ENSG00000124486 E006 56.7869228 0.0408928527 1.649045e-06 1.305993e-05 X 41085715 41085741 27 + 1.838 1.314 -1.793
ENSG00000124486 E007 50.5016986 0.0013851367 1.783576e-18 9.523481e-17 X 41085742 41085756 15 + 1.794 1.213 -1.997
ENSG00000124486 E008 48.3113612 0.1094451568 9.875222e-05 5.160344e-04 X 41085757 41085769 13 + 1.779 1.162 -2.129
ENSG00000124486 E009 45.6249113 0.0628473217 3.539109e-06 2.607325e-05 X 41085770 41085775 6 + 1.755 1.127 -2.173
ENSG00000124486 E010 153.2104524 0.0295836676 9.415643e-10 1.403103e-08 X 41085776 41086109 334 + 2.265 1.726 -1.810
ENSG00000124486 E011 3.8613086 0.0429691186 2.568571e-03 8.968578e-03 X 41086700 41086853 154 + 0.778 0.185 -3.239
ENSG00000124486 E012 2.0961692 0.0376767926 5.317329e-02 1.147993e-01 X 41086854 41086857 4 + 0.556 0.185 -2.296
ENSG00000124486 E013 3.2314007 0.1390135742 2.778617e-03 9.609884e-03 X 41086858 41086952 95 + 0.731 0.000 -13.997
ENSG00000124486 E014 0.8105550 0.0139107362 6.561221e-01 7.658263e-01 X 41087286 41087289 4 + 0.255 0.185 -0.596
ENSG00000124486 E015 1.6857439 0.0717184851 1.463065e-01 2.566584e-01 X 41087290 41087361 72 + 0.477 0.185 -1.909
ENSG00000124486 E016 3.9742280 0.0169380480 7.544268e-03 2.262958e-02 X 41087617 41087665 49 + 0.778 0.313 -2.243
ENSG00000124486 E017 175.4632379 0.0207025651 1.932433e-13 5.278446e-12 X 41123471 41123724 254 + 2.327 1.762 -1.896
ENSG00000124486 E018 157.7569446 0.0299318180 1.424878e-08 1.707285e-07 X 41129000 41129145 146 + 2.272 1.781 -1.648
ENSG00000124486 E019 127.3896124 0.0634825440 1.032278e-05 6.841420e-05 X 41131457 41131536 80 + 2.183 1.666 -1.738
ENSG00000124486 E020 140.9275338 0.0399729405 1.301237e-07 1.293026e-06 X 41134725 41134837 113 + 2.227 1.711 -1.734
ENSG00000124486 E021 195.1854796 0.0175290435 4.698655e-11 8.764055e-10 X 41136804 41137022 219 + 2.358 1.914 -1.488
ENSG00000124486 E022 136.4733248 0.0229384938 1.476369e-08 1.763956e-07 X 41140656 41140771 116 + 2.203 1.761 -1.483
ENSG00000124486 E023 194.5570078 0.0304768723 5.508074e-07 4.834172e-06 X 41140966 41141217 252 + 2.352 1.940 -1.377
ENSG00000124486 E024 148.0500752 0.0344423203 9.928841e-06 6.604597e-05 X 41141293 41141431 139 + 2.229 1.845 -1.289
ENSG00000124486 E025 194.4199717 0.0270320299 5.272870e-09 6.850428e-08 X 41143291 41143443 153 + 2.360 1.889 -1.576
ENSG00000124486 E026 176.7155040 0.0204780454 4.133216e-10 6.573968e-09 X 41144522 41144626 105 + 2.316 1.860 -1.527
ENSG00000124486 E027 204.3983549 0.0159718436 9.808666e-10 1.457086e-08 X 41148369 41148575 207 + 2.370 1.979 -1.305
ENSG00000124486 E028 182.5943609 0.0085320677 8.809311e-13 2.182707e-11 X 41150921 41151057 137 + 2.318 1.946 -1.244
ENSG00000124486 E029 30.8185202 0.0074649203 1.686764e-05 1.063721e-04 X 41152933 41152947 15 + 1.550 1.201 -1.211
ENSG00000124486 E030 203.7636873 0.0013232998 1.651142e-30 2.888309e-28 X 41152948 41153081 134 + 2.367 1.984 -1.281
ENSG00000124486 E031 178.7397805 0.0002007695 2.938976e-36 7.754598e-34 X 41162790 41162877 88 + 2.312 1.922 -1.307
ENSG00000124486 E032 347.8848670 0.0005615531 7.274605e-45 3.361346e-42 X 41165872 41166214 343 + 2.591 2.259 -1.107
ENSG00000124486 E033 0.2966881 0.0270487588 5.828453e-01   X 41167145 41167481 337 + 0.146 0.000 -10.543
ENSG00000124486 E034 181.1935271 0.0115685774 4.138093e-08 4.539634e-07 X 41167482 41167577 96 + 2.303 2.000 -1.015
ENSG00000124486 E035 279.6420776 0.0015005541 1.947456e-33 4.245567e-31 X 41168007 41168218 212 + 2.501 2.137 -1.213
ENSG00000124486 E036 0.7771569 0.0153787590 6.540930e-01 7.643754e-01 X 41168219 41168242 24 + 0.255 0.184 -0.598
ENSG00000124486 E037 171.7717999 0.0002402978 3.365393e-29 5.269121e-27 X 41169995 41170067 73 + 2.287 1.941 -1.160
ENSG00000124486 E038 225.0855923 0.0088694804 5.524828e-10 8.593990e-09 X 41170068 41170235 168 + 2.397 2.092 -1.016
ENSG00000124486 E039 240.3115047 0.0248408556 1.688265e-04 8.301231e-04 X 41170470 41170619 150 + 2.416 2.161 -0.852
ENSG00000124486 E040 224.7037279 0.0095908914 3.726566e-07 3.381957e-06 X 41171838 41171958 121 + 2.385 2.140 -0.817
ENSG00000124486 E041 0.1515154 0.0432636474 1.000000e+00   X 41183994 41183997 4 + 0.079 0.000 -9.543
ENSG00000124486 E042 222.9994835 0.0097799538 6.662266e-07 5.748002e-06 X 41183998 41184128 131 + 2.380 2.140 -0.804
ENSG00000124486 E043 336.7842241 0.0054798092 1.553446e-10 2.652986e-09 X 41184397 41184675 279 + 2.558 2.318 -0.802
ENSG00000124486 E044 0.0000000       X 41184676 41184740 65 +      
ENSG00000124486 E045 224.6748348 0.0005959049 2.083520e-14 6.542627e-13 X 41186517 41186642 126 + 2.372 2.179 -0.648
ENSG00000124486 E046 128.1971437 0.0002786412 4.022960e-05 2.317443e-04 X 41187992 41188065 74 + 2.110 1.998 -0.378
ENSG00000124486 E047 127.4925052 0.0015980278 1.883002e-05 1.175074e-04 X 41188066 41188117 52 + 2.115 1.974 -0.472
ENSG00000124486 E048 219.6917119 0.0010722260 6.755049e-09 8.598560e-08 X 41189309 41189475 167 + 2.353 2.204 -0.497
ENSG00000124486 E049 0.3332198 0.0289950839 5.129797e-01   X 41189476 41189922 447 + 0.079 0.184 1.403
ENSG00000124486 E050 0.1472490 0.0436766774 1.000000e+00   X 41195905 41196005 101 + 0.079 0.000 -9.543
ENSG00000124486 E051 207.3136192 0.0069856488 2.068939e-04 9.935216e-04 X 41196251 41196359 109 + 2.327 2.180 -0.492
ENSG00000124486 E052 261.9698619 0.0063705927 6.201632e-06 4.322910e-05 X 41196592 41196738 147 + 2.435 2.260 -0.585
ENSG00000124486 E053 254.6665836 0.0035849446 2.331027e-04 1.104540e-03 X 41197364 41197510 147 + 2.406 2.299 -0.356
ENSG00000124486 E054 287.5757763 0.0042225344 1.836146e-01 3.057411e-01 X 41198528 41198750 223 + 2.433 2.417 -0.053
ENSG00000124486 E055 387.7143985 0.0001778118 2.180420e-04 1.041118e-03 X 41201060 41201280 221 + 2.570 2.529 -0.138
ENSG00000124486 E056 2.1724642 0.0067762461 6.549444e-02 1.358649e-01 X 41205059 41205302 244 + 0.343 0.673 1.625
ENSG00000124486 E057 371.3902695 0.0001405167 3.945923e-02 9.003074e-02 X 41205303 41205493 191 + 2.541 2.533 -0.027
ENSG00000124486 E058 324.8051434 0.0004797023 8.456115e-01 9.039888e-01 X 41210509 41210682 174 + 2.468 2.506 0.128
ENSG00000124486 E059 309.1455859 0.0001749177 5.877950e-01 7.110584e-01 X 41214568 41214709 142 + 2.452 2.474 0.073
ENSG00000124486 E060 1034.2457095 0.0006512960 1.207876e-04 6.176210e-04 X 41215899 41216652 754 + 2.950 3.047 0.321
ENSG00000124486 E061 315.6897503 0.0001442430 7.937985e-16 3.036808e-14 X 41217220 41217343 124 + 2.395 2.598 0.679
ENSG00000124486 E062 354.1665487 0.0001837149 2.058448e-11 4.070209e-10 X 41218372 41218502 131 + 2.458 2.628 0.567
ENSG00000124486 E063 318.3910216 0.0006160508 4.719936e-10 7.420562e-09 X 41218503 41218597 95 + 2.408 2.588 0.601
ENSG00000124486 E064 382.2476861 0.0001775529 1.509044e-17 7.221112e-16 X 41219102 41219231 130 + 2.478 2.678 0.666
ENSG00000124486 E065 504.1239104 0.0005998305 8.302617e-34 1.863632e-31 X 41223217 41223402 186 + 2.568 2.840 0.905
ENSG00000124486 E066 594.1667159 0.0013518907 1.190636e-23 1.135191e-21 X 41224742 41224962 221 + 2.643 2.906 0.875
ENSG00000124486 E067 413.6621393 0.0011774964 2.520004e-32 4.988582e-30 X 41225049 41225137 89 + 2.460 2.778 1.057
ENSG00000124486 E068 1.9949245 0.0075139401 7.950052e-03 2.365239e-02 X 41228983 41229252 270 + 0.255 0.719 2.402
ENSG00000124486 E069 527.7635213 0.0034875824 1.627779e-25 1.878063e-23 X 41229253 41229409 157 + 2.539 2.909 1.229
ENSG00000124486 E070 606.1246125 0.0069567833 2.409259e-19 1.432152e-17 X 41229567 41229779 213 + 2.575 2.990 1.379
ENSG00000124486 E071 21.3402607 0.0013484169 2.323427e-05 1.419021e-04 X 41229780 41229827 48 + 1.176 1.529 1.227
ENSG00000124486 E072 1.5824134 0.0088194129 9.461731e-01 9.702124e-01 X 41229828 41229896 69 + 0.380 0.413 0.180
ENSG00000124486 E073 444.5438437 0.0067748169 6.131281e-20 3.856417e-18 X 41230501 41230596 96 + 2.433 2.862 1.429
ENSG00000124486 E074 0.4375944 0.0266626706 3.389085e-01 4.828185e-01 X 41230597 41230606 10 + 0.204 0.000 -11.127
ENSG00000124486 E075 1576.5352840 0.0104884425 6.930247e-19 3.893578e-17 X 41232387 41236579 4193 + 2.972 3.418 1.481