ENSG00000124406

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264449 ENSG00000124406 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP8A1 protein_coding protein_coding 2.175822 0.4135341 3.870972 0.01858587 0.2108625 3.195868 1.2854339 0.1792791 2.78894339 0.04508819 0.11528002 3.886295 0.5316583 0.4311 0.72150000 0.29040000 0.01627999 0.00130314 FALSE TRUE
ENST00000504024 ENSG00000124406 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP8A1 protein_coding nonsense_mediated_decay 2.175822 0.4135341 3.870972 0.01858587 0.2108625 3.195868 0.1417670 0.0000000 0.00000000 0.00000000 0.00000000 0.000000 0.0613500 0.0000 0.00000000 0.00000000   0.00130314   FALSE
ENST00000504510 ENSG00000124406 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP8A1 protein_coding retained_intron 2.175822 0.4135341 3.870972 0.01858587 0.2108625 3.195868 0.2428558 0.0000000 0.32942506 0.00000000 0.08442974 5.085021 0.1076833 0.0000 0.08553333 0.08553333 0.15568271 0.00130314   FALSE
ENST00000514372 ENSG00000124406 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP8A1 protein_coding nonsense_mediated_decay 2.175822 0.4135341 3.870972 0.01858587 0.2108625 3.195868 0.2138697 0.2342550 0.06694164 0.04120765 0.06694164 -1.666551 0.2126125 0.5689 0.01886667 -0.55003333 0.00130314 0.00130314 FALSE TRUE
MSTRG.24809.4 ENSG00000124406 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP8A1 protein_coding   2.175822 0.4135341 3.870972 0.01858587 0.2108625 3.195868 0.1248839 0.0000000 0.40903088 0.00000000 0.21506981 5.388985 0.0307750 0.0000 0.10376667 0.10376667 0.62808326 0.00130314 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124406 E001 0.1482932 0.0415216615 3.210727e-02   4 42408373 42408376 4 - 0.000 0.298 11.551
ENSG00000124406 E002 185.8555264 0.0005402974 9.635864e-13 2.373226e-11 4 42408377 42412974 4598 - 2.048 2.266 0.727
ENSG00000124406 E003 10.0293103 0.0058171037 5.078731e-01 6.432991e-01 4 42412975 42413013 39 - 0.884 0.773 -0.432
ENSG00000124406 E004 15.5790453 0.0017862083 2.655263e-01 4.035941e-01 4 42414627 42414718 92 - 1.057 0.898 -0.593
ENSG00000124406 E005 0.4470576 0.0228542953 2.273496e-01 3.592313e-01 4 42414719 42415147 429 - 0.084 0.298 2.198
ENSG00000124406 E006 14.0644985 0.0016323255 1.116993e-01 2.080548e-01 4 42422807 42422899 93 - 1.023 0.773 -0.954
ENSG00000124406 E007 13.7158620 0.0013150754 2.753525e-01 4.146473e-01 4 42423617 42423705 89 - 1.005 0.840 -0.625
ENSG00000124406 E008 15.7142137 0.0011221272 4.520770e-01 5.929714e-01 4 42443565 42443672 108 - 1.053 0.949 -0.385
ENSG00000124406 E009 13.0709924 0.0147538656 6.343800e-01 7.488544e-01 4 42444578 42444634 57 - 0.977 0.899 -0.294
ENSG00000124406 E010 15.6257562 0.0012128994 3.329535e-01 4.766257e-01 4 42446583 42446644 62 - 1.024 1.141 0.425
ENSG00000124406 E011 15.3852577 0.0011882541 9.724992e-01 9.868531e-01 4 42451981 42452059 79 - 1.032 1.036 0.014
ENSG00000124406 E012 16.7365592 0.0011750579 1.960920e-01 3.213309e-01 4 42455297 42455419 123 - 1.049 1.199 0.537
ENSG00000124406 E013 0.3030308 0.2737225978 1.000000e+00   4 42455420 42455433 14 - 0.085 0.000 -11.477
ENSG00000124406 E014 9.3590041 0.0018127071 2.215723e-01 3.522883e-01 4 42455525 42455599 75 - 0.818 0.995 0.669
ENSG00000124406 E015 0.0000000       4 42459358 42459532 175 -      
ENSG00000124406 E016 10.2261526 0.0019398633 3.404453e-01 4.843986e-01 4 42464690 42464800 111 - 0.859 0.995 0.511
ENSG00000124406 E017 12.5231069 0.0129104444 9.627891e-01 9.804871e-01 4 42464893 42465076 184 - 0.957 0.949 -0.029
ENSG00000124406 E018 14.3303442 0.0011943995 9.794184e-02 1.873805e-01 4 42485496 42485668 173 - 1.032 0.773 -0.986
ENSG00000124406 E019 11.2810607 0.0015341769 3.341327e-01 4.778834e-01 4 42503450 42503514 65 - 0.930 0.773 -0.608
ENSG00000124406 E020 14.2486448 0.0012460606 2.225610e-01 3.534509e-01 4 42507016 42507154 139 - 1.023 0.840 -0.691
ENSG00000124406 E021 15.8982463 0.0013887569 6.646215e-01 7.724336e-01 4 42522160 42522299 140 - 1.053 0.995 -0.215
ENSG00000124406 E022 11.7837920 0.0015012591 8.039548e-01 8.752411e-01 4 42524763 42524847 85 - 0.936 0.898 -0.143
ENSG00000124406 E023 10.5134913 0.0015806646 6.240346e-01 7.404995e-01 4 42543917 42543986 70 - 0.878 0.949 0.269
ENSG00000124406 E024 7.9305237 0.0024491693 6.797472e-01 7.838435e-01 4 42549013 42549062 50 - 0.774 0.840 0.261
ENSG00000124406 E025 10.3642822 0.0018288967 4.567370e-01 5.971208e-01 4 42551198 42551280 83 - 0.896 0.773 -0.479
ENSG00000124406 E026 8.2696864 0.0122729770 1.699630e-02 4.492547e-02 4 42552505 42552554 50 - 0.839 0.298 -2.582
ENSG00000124406 E027 7.5310237 0.0024809892 2.384926e-02 5.949737e-02 4 42552555 42552610 56 - 0.804 0.298 -2.444
ENSG00000124406 E028 8.1496571 0.0021366920 1.620330e-02 4.317211e-02 4 42555968 42556040 73 - 0.832 0.298 -2.555
ENSG00000124406 E029 0.0000000       4 42556041 42556235 195 -      
ENSG00000124406 E030 0.0000000       4 42569161 42569205 45 -      
ENSG00000124406 E031 10.6570827 0.0056496428 4.217044e-01 5.648320e-01 4 42574619 42574707 89 - 0.908 0.773 -0.524
ENSG00000124406 E032 14.7045525 0.0011953351 9.356692e-03 2.717457e-02 4 42575622 42575699 78 - 1.049 0.598 -1.785
ENSG00000124406 E033 18.7052973 0.0009794261 4.119542e-03 1.347692e-02 4 42578260 42578387 128 - 1.146 0.694 -1.719
ENSG00000124406 E034 16.2407555 0.0010731930 1.069987e-01 2.011059e-01 4 42579813 42579978 166 - 1.077 0.840 -0.888
ENSG00000124406 E035 8.7525957 0.0018882362 1.963556e-01 3.216681e-01 4 42581621 42581681 61 - 0.839 0.598 -0.997
ENSG00000124406 E036 5.6534548 0.0234951544 7.436921e-01 8.322812e-01 4 42581682 42581691 10 - 0.668 0.598 -0.302
ENSG00000124406 E037 7.6246399 0.0283434733 1.412817e-01 2.498007e-01 4 42581692 42581732 41 - 0.797 0.473 -1.420
ENSG00000124406 E038 12.3610742 0.0880179541 6.750894e-01 7.804637e-01 4 42586349 42586476 128 - 0.959 0.845 -0.432
ENSG00000124406 E039 8.8310714 0.0033079915 4.388959e-01 5.807112e-01 4 42588260 42588329 70 - 0.832 0.694 -0.555
ENSG00000124406 E040 1.7692921 0.0681558499 2.680772e-01 4.064898e-01 4 42588330 42588617 288 - 0.359 0.000 -14.067
ENSG00000124406 E041 1.3381542 0.0099995774 3.900362e-01 5.340696e-01 4 42590811 42590884 74 - 0.294 0.000 -13.930
ENSG00000124406 E042 8.1486235 0.0022051153 2.578838e-01 3.950610e-01 4 42594289 42594362 74 - 0.811 0.598 -0.888
ENSG00000124406 E043 6.4517754 0.0300430267 6.625643e-01 7.708467e-01 4 42600478 42600518 41 - 0.696 0.775 0.321
ENSG00000124406 E044 7.3117645 0.0023796274 7.272962e-01 8.200648e-01 4 42616033 42616078 46 - 0.758 0.694 -0.259
ENSG00000124406 E045 4.9134975 0.0032838205 1.320215e-01 2.369241e-01 4 42624536 42624570 35 - 0.647 0.298 -1.800
ENSG00000124406 E046 6.8762464 0.0024343198 8.358996e-01 8.974066e-01 4 42624571 42624634 64 - 0.733 0.694 -0.157
ENSG00000124406 E047 0.0000000       4 42625141 42625613 473 -      
ENSG00000124406 E048 7.4527820 0.0101128328 3.048565e-01 4.468821e-01 4 42625614 42625713 100 - 0.732 0.899 0.653
ENSG00000124406 E049 0.0000000       4 42625714 42626994 1281 -      
ENSG00000124406 E050 6.6740438 0.0137556890 4.998915e-01 6.361538e-01 4 42626995 42627053 59 - 0.733 0.598 -0.572
ENSG00000124406 E051 4.8886191 0.0032691289 1.319236e-01 2.367928e-01 4 42627054 42627109 56 - 0.647 0.298 -1.801
ENSG00000124406 E052 5.1038353 0.0161916096 4.229261e-01 5.660658e-01 4 42656825 42657105 281 - 0.647 0.473 -0.800