ENSG00000124333

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262640 ENSG00000124333 HEK293_OSMI2_2hA HEK293_TMG_2hB VAMP7 protein_coding protein_coding 25.48003 14.49985 41.637 2.161529 1.144345 1.52118 1.132228 1.492972 0.9510721 0.1158755 0.333586 -0.6451014 0.05397917 0.1093667 0.02243333 -0.08693333 0.009548662 0.009548662 FALSE TRUE
ENST00000286448 ENSG00000124333 HEK293_OSMI2_2hA HEK293_TMG_2hB VAMP7 protein_coding protein_coding 25.48003 14.49985 41.637 2.161529 1.144345 1.52118 21.713284 10.636214 35.7877006 1.4130954 1.640468 1.7495265 0.84625417 0.7368667 0.85906667 0.12220000 0.025661580 0.009548662 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124333 E001 1.652232 0.0937179797 2.472590e-01 3.827093e-01 X 155881292 155881317 26 + 0.418 0.219 -1.302
ENSG00000124333 E002 8.649211 0.0347566834 2.715104e-02 6.630507e-02 X 155881318 155881344 27 + 0.966 0.694 -1.063
ENSG00000124333 E003 30.529214 0.0279956321 1.758865e-02 4.624278e-02 X 155881345 155881357 13 + 1.455 1.293 -0.562
ENSG00000124333 E004 35.185574 0.0038378926 5.248411e-04 2.252443e-03 X 155881358 155881359 2 + 1.515 1.355 -0.551
ENSG00000124333 E005 45.774625 0.0331793253 6.378458e-02 1.329988e-01 X 155881360 155881371 12 + 1.614 1.520 -0.322
ENSG00000124333 E006 49.442047 0.0320934971 4.775557e-02 1.051859e-01 X 155881372 155881374 3 + 1.648 1.545 -0.352
ENSG00000124333 E007 55.091685 0.0285736099 3.593778e-02 8.346580e-02 X 155881375 155881377 3 + 1.695 1.591 -0.353
ENSG00000124333 E008 103.202536 0.0103116323 3.620991e-04 1.627063e-03 X 155881378 155881448 71 + 1.968 1.846 -0.412
ENSG00000124333 E009 103.271209 0.0057992683 7.869006e-07 6.685021e-06 X 155889458 155889495 38 + 1.978 1.809 -0.568
ENSG00000124333 E010 124.456280 0.0046251679 1.645309e-07 1.602977e-06 X 155889496 155889547 52 + 2.055 1.898 -0.526
ENSG00000124333 E011 133.013740 0.0096765307 1.395867e-03 5.292984e-03 X 155889548 155889608 61 + 2.070 1.987 -0.279
ENSG00000124333 E012 78.400712 0.0003737538 3.165217e-06 2.355597e-05 X 155889609 155889612 4 + 1.850 1.743 -0.360
ENSG00000124333 E013 2.142265 0.0067878608 7.727841e-01 8.533331e-01 X 155889613 155889633 21 + 0.444 0.472 0.142
ENSG00000124333 E014 124.501958 0.0002609346 1.394615e-07 1.378225e-06 X 155895623 155895680 58 + 2.043 1.964 -0.268
ENSG00000124333 E015 223.332666 0.0001767467 7.792506e-06 5.307067e-05 X 155898112 155898249 138 + 2.279 2.279 0.000
ENSG00000124333 E016 97.601670 0.0007554408 1.517604e-03 5.693178e-03 X 155900497 155900499 3 + 1.927 1.911 -0.053
ENSG00000124333 E017 188.220544 0.0006595940 2.929238e-02 7.056925e-02 X 155900500 155900587 88 + 2.192 2.246 0.180
ENSG00000124333 E018 154.466688 0.0002686396 2.878301e-01 4.283771e-01 X 155919813 155919880 68 + 2.099 2.188 0.295
ENSG00000124333 E019 174.357470 0.0002960590 2.460046e-01 3.812658e-01 X 155939701 155939793 93 + 2.149 2.235 0.288
ENSG00000124333 E020 1324.637106 0.0103305499 4.026305e-09 5.337799e-08 X 155941883 155943769 1887 + 2.964 3.250 0.951