ENSG00000124313

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000485377 ENSG00000124313 HEK293_OSMI2_2hA HEK293_TMG_2hB IQSEC2 protein_coding protein_coding 5.525543 8.748572 4.470385 0.3128799 0.1106954 -0.967073 0.4587390 1.1719770 0.2679984 0.30612223 0.0951525 -2.08805327 0.07319583 0.13486667 0.06053333 -0.07433333 0.379856794 0.003194485 FALSE FALSE
ENST00000498281 ENSG00000124313 HEK293_OSMI2_2hA HEK293_TMG_2hB IQSEC2 protein_coding protein_coding 5.525543 8.748572 4.470385 0.3128799 0.1106954 -0.967073 0.1735074 0.3917304 0.4523982 0.19815203 0.2985786 0.20290797 0.02862917 0.04506667 0.09933333 0.05426667 0.916814311 0.003194485   FALSE
ENST00000639161 ENSG00000124313 HEK293_OSMI2_2hA HEK293_TMG_2hB IQSEC2 protein_coding protein_coding 5.525543 8.748572 4.470385 0.3128799 0.1106954 -0.967073 1.8048776 3.4232211 0.9122771 0.29193588 0.1189514 -1.89629052 0.30909583 0.39040000 0.20393333 -0.18646667 0.003194485 0.003194485 FALSE FALSE
ENST00000640442 ENSG00000124313 HEK293_OSMI2_2hA HEK293_TMG_2hB IQSEC2 protein_coding retained_intron 5.525543 8.748572 4.470385 0.3128799 0.1106954 -0.967073 0.4679014 0.3406018 0.3624455 0.08552081 0.1479407 0.08719586 0.09390833 0.03843333 0.07990000 0.04146667 0.488521059 0.003194485 FALSE TRUE
ENST00000640694 ENSG00000124313 HEK293_OSMI2_2hA HEK293_TMG_2hB IQSEC2 protein_coding protein_coding 5.525543 8.748572 4.470385 0.3128799 0.1106954 -0.967073 2.0345012 2.9425820 1.7534144 0.31844383 0.1303212 -0.74360558 0.36671250 0.33466667 0.39420000 0.05953333 0.638749676 0.003194485 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124313 E001 0.0000000       X 53225828 53225830 3 -      
ENSG00000124313 E002 0.5212538 0.0202868604 1.000000e+00 1.000000e+00 X 53225831 53227865 2035 - 0.165 0.164 -0.014
ENSG00000124313 E003 0.7665478 0.0171037803 3.363782e-02 7.903980e-02 X 53228823 53231061 2239 - 0.455 0.090 -3.014
ENSG00000124313 E004 1.4446276 0.0177299360 1.759284e-01 2.959089e-01 X 53231062 53231870 809 - 0.520 0.282 -1.337
ENSG00000124313 E005 0.0000000       X 53232874 53232874 1 -      
ENSG00000124313 E006 0.0000000       X 53232875 53232875 1 -      
ENSG00000124313 E007 150.9586959 0.0003705550 5.860868e-05 3.245331e-04 X 53232876 53234109 1234 - 2.044 2.167 0.414
ENSG00000124313 E008 51.6213863 0.0004964433 2.973074e-02 7.142910e-02 X 53234110 53235095 986 - 1.590 1.707 0.397
ENSG00000124313 E009 8.6269824 0.0042026298 8.172730e-01 8.844543e-01 X 53235096 53235184 89 - 0.970 0.943 -0.098
ENSG00000124313 E010 0.1817044 0.0395804942 1.000000e+00   X 53235783 53235832 50 - 0.000 0.090 10.643
ENSG00000124313 E011 15.8809955 0.0026726981 3.253191e-02 7.686643e-02 X 53236322 53236395 74 - 1.300 1.112 -0.668
ENSG00000124313 E012 23.4395437 0.0010583576 2.359162e-01 3.694438e-01 X 53236396 53236495 100 - 1.399 1.311 -0.304
ENSG00000124313 E013 1.6565078 0.0180930041 6.551284e-01 7.650804e-01 X 53237421 53237516 96 - 0.455 0.375 -0.430
ENSG00000124313 E014 5.1672490 0.1106836772 4.427578e-01 5.843322e-01 X 53237783 53238144 362 - 0.847 0.698 -0.596
ENSG00000124313 E015 30.9114771 0.0007047527 5.185319e-01 6.527630e-01 X 53238145 53238306 162 - 1.486 1.444 -0.143
ENSG00000124313 E016 20.6262532 0.0045517457 1.281279e-01 2.315549e-01 X 53239195 53239294 100 - 1.374 1.249 -0.435
ENSG00000124313 E017 1.5823989 0.0133899906 1.757771e-01 2.956978e-01 X 53239540 53239589 50 - 0.520 0.283 -1.332
ENSG00000124313 E018 0.1817044 0.0395804942 1.000000e+00   X 53241150 53241783 634 - 0.000 0.090 10.643
ENSG00000124313 E019 27.1388332 0.0007917860 4.537772e-04 1.981622e-03 X 53241784 53241909 126 - 1.558 1.325 -0.802
ENSG00000124313 E020 0.2214452 0.0378989751 1.000000e+00   X 53241910 53242187 278 - 0.000 0.090 10.653
ENSG00000124313 E021 0.0000000       X 53243054 53243331 278 -      
ENSG00000124313 E022 27.5308936 0.0007809581 2.437097e-03 8.572876e-03 X 53243332 53243471 140 - 1.541 1.339 -0.696
ENSG00000124313 E023 32.5042327 0.0218605072 2.056460e-01 3.332423e-01 X 53246969 53247135 167 - 1.547 1.443 -0.357
ENSG00000124313 E024 24.3323697 0.0008573451 9.525772e-01 9.743112e-01 X 53248114 53248236 123 - 1.357 1.353 -0.013
ENSG00000124313 E025 0.6224193 0.0180672625 4.906305e-01 6.279708e-01 X 53248237 53248446 210 - 0.284 0.164 -1.015
ENSG00000124313 E026 30.0128640 0.0007231473 2.139392e-02 5.442125e-02 X 53248721 53248882 162 - 1.547 1.399 -0.509
ENSG00000124313 E027 67.8347301 0.0015566744 7.806179e-04 3.189667e-03 X 53250279 53251094 816 - 1.891 1.739 -0.514
ENSG00000124313 E028 12.4141133 0.0015076159 8.709625e-02 1.707398e-01 X 53251095 53251174 80 - 1.199 1.035 -0.588
ENSG00000124313 E029 30.5122470 0.0163423387 3.464903e-02 8.098296e-02 X 53254530 53254931 402 - 1.569 1.393 -0.604
ENSG00000124313 E030 24.9164064 0.0014788215 1.454581e-03 5.488708e-03 X 53255800 53256061 262 - 1.511 1.287 -0.778
ENSG00000124313 E031 0.4782907 0.0235680753 2.587789e-01 3.960999e-01 X 53266324 53266327 4 - 0.000 0.227 12.246
ENSG00000124313 E032 1.0694743 0.0118981805 5.587131e-02 1.194670e-01 X 53266328 53266328 1 - 0.000 0.375 13.237
ENSG00000124313 E033 2.8356659 0.0056453562 2.050813e-01 3.325064e-01 X 53266329 53266338 10 - 0.378 0.600 1.102
ENSG00000124313 E034 67.8120738 0.0089718415 6.371482e-06 4.429734e-05 X 53266339 53266641 303 - 1.563 1.866 1.027
ENSG00000124313 E035 43.3324920 0.0005498445 3.145067e-03 1.069240e-02 X 53266642 53266707 66 - 1.472 1.648 0.602
ENSG00000124313 E036 33.1111107 0.0006535610 9.204923e-03 2.679747e-02 X 53266708 53266764 57 - 1.357 1.534 0.611
ENSG00000124313 E037 23.6395079 0.0008720975 5.603134e-03 1.756108e-02 X 53266765 53266884 120 - 1.172 1.399 0.794
ENSG00000124313 E038 9.6903215 0.0018772008 2.412686e-03 8.499980e-03 X 53266885 53266968 84 - 0.672 1.062 1.510
ENSG00000124313 E039 24.0518485 0.0066327418 2.392908e-02 5.965502e-02 X 53266969 53267064 96 - 1.211 1.410 0.694
ENSG00000124313 E040 0.6966155 0.0166886706 7.329716e-01 8.243108e-01 X 53279155 53279563 409 - 0.165 0.227 0.571
ENSG00000124313 E041 28.2434440 0.0066704005 6.233244e-01 7.399336e-01 X 53279564 53279659 96 - 1.399 1.439 0.140
ENSG00000124313 E042 3.5947396 0.0908718845 8.496405e-01 9.066944e-01 X 53279660 53279776 117 - 0.671 0.621 -0.216
ENSG00000124313 E043 28.0671032 0.0067988868 6.055133e-01 7.258826e-01 X 53281496 53282026 531 - 1.452 1.414 -0.131
ENSG00000124313 E044 5.8500331 0.0052331233 5.373005e-01 6.689096e-01 X 53291895 53291924 30 - 0.846 0.765 -0.320
ENSG00000124313 E045 24.6376267 0.0167901805 2.626402e-02 6.447862e-02 X 53320417 53321350 934 - 1.492 1.296 -0.681