ENSG00000124279

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264669 ENSG00000124279 HEK293_OSMI2_2hA HEK293_TMG_2hB FASTKD3 protein_coding protein_coding 8.098877 4.343028 12.27159 0.2919659 0.5171891 1.496406 3.2152335 1.5580098 4.5872614 0.16006302 0.38095958 1.551840 0.41323333 0.36256667 0.37596667 0.01340000 9.490138e-01 1.702722e-07 FALSE TRUE
ENST00000282110 ENSG00000124279 HEK293_OSMI2_2hA HEK293_TMG_2hB FASTKD3 protein_coding processed_transcript 8.098877 4.343028 12.27159 0.2919659 0.5171891 1.496406 1.7196560 1.6554520 3.7139196 0.40249268 0.63378762 1.160908 0.20738333 0.37583333 0.30033333 -0.07550000 7.521169e-01 1.702722e-07 FALSE FALSE
ENST00000513577 ENSG00000124279 HEK293_OSMI2_2hA HEK293_TMG_2hB FASTKD3 protein_coding retained_intron 8.098877 4.343028 12.27159 0.2919659 0.5171891 1.496406 0.5577007 0.1867412 0.8393197 0.03653572 0.05247033 2.110008 0.08055833 0.04316667 0.06830000 0.02513333 3.547997e-01 1.702722e-07   FALSE
ENST00000513658 ENSG00000124279 HEK293_OSMI2_2hA HEK293_TMG_2hB FASTKD3 protein_coding processed_transcript 8.098877 4.343028 12.27159 0.2919659 0.5171891 1.496406 0.5024001 0.5235025 0.0000000 0.26422992 0.00000000 -5.737423 0.11600417 0.12100000 0.00000000 -0.12100000 6.218047e-02 1.702722e-07 TRUE FALSE
MSTRG.25924.3 ENSG00000124279 HEK293_OSMI2_2hA HEK293_TMG_2hB FASTKD3 protein_coding   8.098877 4.343028 12.27159 0.2919659 0.5171891 1.496406 0.3424970 0.0000000 0.7040582 0.00000000 0.37171657 6.157970 0.02572083 0.00000000 0.05546667 0.05546667 3.319071e-01 1.702722e-07 TRUE TRUE
MSTRG.25924.6 ENSG00000124279 HEK293_OSMI2_2hA HEK293_TMG_2hB FASTKD3 protein_coding   8.098877 4.343028 12.27159 0.2919659 0.5171891 1.496406 0.9600458 0.0000000 1.5132938 0.00000000 0.34298144 7.251050 0.07439167 0.00000000 0.12403333 0.12403333 1.702722e-07 1.702722e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124279 E001 3.680605 0.0347346924 0.0094532004 0.027418290 5 7859159 7859271 113 - 0.481 0.890 1.738
ENSG00000124279 E002 12.807457 0.0013358295 0.0047388817 0.015202217 5 7859272 7859293 22 - 1.014 1.274 0.932
ENSG00000124279 E003 12.670792 0.0013887464 0.0147381244 0.039899589 5 7859294 7859309 16 - 1.022 1.249 0.813
ENSG00000124279 E004 19.661350 0.0009962441 0.1013284920 0.192493144 5 7859310 7859335 26 - 1.246 1.371 0.436
ENSG00000124279 E005 22.114058 0.0009149529 0.0672184271 0.138727252 5 7859336 7859380 45 - 1.293 1.425 0.459
ENSG00000124279 E006 24.702456 0.0098378452 0.9843694359 0.994304768 5 7859381 7859396 16 - 1.389 1.386 -0.010
ENSG00000124279 E007 24.733586 0.0011893295 0.3264125578 0.469857000 5 7859397 7859402 6 - 1.367 1.433 0.229
ENSG00000124279 E008 63.956246 0.0005662278 0.0348353671 0.081333183 5 7859403 7859539 137 - 1.758 1.848 0.303
ENSG00000124279 E009 60.701956 0.0016520975 0.0088965181 0.026022398 5 7861149 7861263 115 - 1.723 1.844 0.409
ENSG00000124279 E010 31.306956 0.0028186855 0.1278831159 0.231221606 5 7861583 7861608 26 - 1.446 1.544 0.334
ENSG00000124279 E011 33.531053 0.0116803675 0.9763651981 0.989219462 5 7861609 7861652 44 - 1.514 1.502 -0.040
ENSG00000124279 E012 8.852062 0.0044855665 0.1213331119 0.221827354 5 7861653 7861773 121 - 0.908 1.078 0.630
ENSG00000124279 E013 57.080513 0.0004970675 0.5822336322 0.706627385 5 7862823 7862997 175 - 1.726 1.747 0.071
ENSG00000124279 E014 4.653336 0.0034367830 0.9961662658 1.000000000 5 7862998 7863296 299 - 0.720 0.715 -0.023
ENSG00000124279 E015 43.375412 0.0005064943 0.8526124278 0.908678465 5 7865898 7865983 86 - 1.616 1.621 0.017
ENSG00000124279 E016 104.041208 0.0003331808 0.0014691558 0.005536976 5 7866646 7867349 704 - 2.028 1.906 -0.412
ENSG00000124279 E017 25.784158 0.0007679456 0.0295057892 0.070978671 5 7867350 7867389 40 - 1.446 1.274 -0.600
ENSG00000124279 E018 33.958463 0.0006172850 0.0008401665 0.003402241 5 7867390 7867489 100 - 1.576 1.341 -0.810
ENSG00000124279 E019 71.330357 0.0135495457 0.0175232271 0.046091528 5 7867490 7867952 463 - 1.876 1.699 -0.599
ENSG00000124279 E020 14.976117 0.0013742621 0.4533410951 0.594076505 5 7867953 7867974 22 - 1.193 1.115 -0.277
ENSG00000124279 E021 18.054558 0.0010493422 0.1337599212 0.239381207 5 7867975 7868032 58 - 1.289 1.148 -0.496
ENSG00000124279 E022 17.619052 0.0010788816 0.3668767269 0.511214458 5 7868033 7868107 75 - 1.265 1.179 -0.303
ENSG00000124279 E023 10.943489 0.0018549997 0.7733102316 0.853717299 5 7868108 7868196 89 - 1.054 1.018 -0.134
ENSG00000124279 E024 12.376476 0.0017203307 0.8898857496 0.933623073 5 7868979 7869037 59 - 1.099 1.079 -0.072