ENSG00000124275

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264668 ENSG00000124275 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRR protein_coding protein_coding 16.15241 6.027969 28.12139 0.8849169 1.125324 2.220046 0.8275444 0.0000000 2.4657533 0.00000000 0.30416754 7.9517237 0.03333750 0.000000000 0.087133333 0.08713333 3.349482e-12 3.349482e-12 FALSE TRUE
ENST00000440940 ENSG00000124275 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRR protein_coding protein_coding 16.15241 6.027969 28.12139 0.8849169 1.125324 2.220046 5.3611840 3.4007376 8.9542279 0.68921827 0.30045721 1.3940956 0.37502917 0.580300000 0.319866667 -0.26043333 3.007678e-01 3.349482e-12 FALSE TRUE
ENST00000507414 ENSG00000124275 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRR protein_coding processed_transcript 16.15241 6.027969 28.12139 0.8849169 1.125324 2.220046 0.3259962 0.3947250 0.2794877 0.08766813 0.05806939 -0.4834396 0.02115000 0.069366667 0.009866667 -0.05950000 2.009178e-04 3.349482e-12 FALSE FALSE
ENST00000510279 ENSG00000124275 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRR protein_coding nonsense_mediated_decay 16.15241 6.027969 28.12139 0.8849169 1.125324 2.220046 0.9599275 0.0000000 3.2800750 0.00000000 1.39158438 8.3619767 0.03505833 0.000000000 0.113266667 0.11326667 9.427819e-06 3.349482e-12   FALSE
ENST00000511461 ENSG00000124275 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRR protein_coding nonsense_mediated_decay 16.15241 6.027969 28.12139 0.8849169 1.125324 2.220046 0.7410206 1.4504939 0.0000000 0.75826161 0.00000000 -7.1903125 0.10212500 0.220800000 0.000000000 -0.22080000 4.768019e-02 3.349482e-12 FALSE TRUE
ENST00000513439 ENSG00000124275 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRR protein_coding nonsense_mediated_decay 16.15241 6.027969 28.12139 0.8849169 1.125324 2.220046 2.7486507 0.0461232 6.1208656 0.04612320 0.86241581 6.7713496 0.14762917 0.008566667 0.216733333 0.20816667 3.875575e-05 3.349482e-12 FALSE TRUE
MSTRG.25923.6 ENSG00000124275 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRR protein_coding   16.15241 6.027969 28.12139 0.8849169 1.125324 2.220046 2.2380382 0.0000000 3.3985379 0.00000000 1.24231105 8.4130092 0.09206250 0.000000000 0.122900000 0.12290000 1.556162e-05 3.349482e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124275 E001 0.6674587 0.0304715992 9.177520e-01 9.520081e-01 5 7851186 7851194 9 + 0.181 0.209 0.254
ENSG00000124275 E002 0.6674587 0.0304715992 9.177520e-01 9.520081e-01 5 7851195 7851199 5 + 0.181 0.209 0.254
ENSG00000124275 E003 2.7312688 0.0210956206 4.978870e-03 1.587158e-02 5 7851200 7851585 386 + 0.344 0.816 2.202
ENSG00000124275 E004 0.7717566 0.0159417221 7.262179e-03 2.190726e-02 5 7856787 7856892 106 + 0.069 0.538 3.832
ENSG00000124275 E005 0.1451727 0.0441080755 1.000000e+00   5 7861485 7861950 466 + 0.069 0.000 -9.964
ENSG00000124275 E006 1.7369356 0.0084529465 3.043174e-01 4.463302e-01 5 7861951 7862057 107 + 0.344 0.539 1.028
ENSG00000124275 E007 0.0000000       5 7869104 7869128 25 +      
ENSG00000124275 E008 0.1451727 0.0441080755 1.000000e+00   5 7869129 7869147 19 + 0.069 0.000 -9.964
ENSG00000124275 E009 0.6696487 0.0389716922 9.149561e-01 9.501509e-01 5 7869148 7869155 8 + 0.181 0.209 0.255
ENSG00000124275 E010 11.6078095 0.0126599978 5.922210e-03 1.840400e-02 5 7869156 7869183 28 + 1.110 0.726 -1.461
ENSG00000124275 E011 13.6093834 0.0025362252 1.004007e-03 3.972475e-03 5 7869184 7869189 6 + 1.175 0.773 -1.503
ENSG00000124275 E012 11.8377995 0.0016516929 3.599248e-02 8.356928e-02 5 7869190 7869193 4 + 1.098 0.854 -0.908
ENSG00000124275 E013 29.9627967 0.0020604559 8.446879e-03 2.490213e-02 5 7869194 7869215 22 + 1.476 1.275 -0.699
ENSG00000124275 E014 0.0000000       5 7869227 7869238 12 +      
ENSG00000124275 E015 0.6631923 0.5107145611 7.446498e-01 8.329004e-01 5 7869239 7869298 60 + 0.181 0.214 0.300
ENSG00000124275 E016 2.2027444 0.0093666117 9.351122e-01 9.631453e-01 5 7869299 7869718 420 + 0.462 0.454 -0.037
ENSG00000124275 E017 0.4375944 0.0258598863 5.430279e-01 6.736937e-01 5 7870261 7870419 159 + 0.181 0.000 -11.552
ENSG00000124275 E018 81.4829320 0.0003258991 1.547716e-03 5.790433e-03 5 7870770 7870923 154 + 1.890 1.755 -0.454
ENSG00000124275 E019 0.2987644 0.0275551195 1.000000e+00   5 7872230 7872305 76 + 0.129 0.000 -10.983
ENSG00000124275 E020 72.3230729 0.0003554257 8.447502e-07 7.129160e-06 5 7873373 7873512 140 + 1.858 1.612 -0.832
ENSG00000124275 E021 33.7126509 0.0006285205 5.323324e-06 3.764700e-05 5 7873513 7873526 14 + 1.550 1.197 -1.223
ENSG00000124275 E022 0.7427016 0.0156731416 2.478205e-01 3.833655e-01 5 7875162 7875257 96 + 0.270 0.000 -12.267
ENSG00000124275 E023 103.7658455 0.0003094806 2.152826e-07 2.050716e-06 5 7875258 7875375 118 + 2.007 1.796 -0.710
ENSG00000124275 E024 46.1806295 0.0013748738 2.315234e-02 5.806537e-02 5 7877944 7877948 5 + 1.649 1.518 -0.448
ENSG00000124275 E025 163.7716892 0.0003100818 5.030781e-05 2.833555e-04 5 7877949 7878322 374 + 2.187 2.066 -0.403
ENSG00000124275 E026 88.8132024 0.0039532066 6.834949e-02 1.406438e-01 5 7883155 7883277 123 + 1.915 1.824 -0.306
ENSG00000124275 E027 0.0000000       5 7885116 7885258 143 +      
ENSG00000124275 E028 89.2129424 0.0004277244 2.607202e-04 1.219572e-03 5 7885701 7885784 84 + 1.931 1.778 -0.516
ENSG00000124275 E029 77.8049450 0.0003410340 8.284488e-02 1.640025e-01 5 7885785 7885854 70 + 1.854 1.787 -0.226
ENSG00000124275 E030 1.3455410 0.0730043091 4.099406e-01 5.535622e-01 5 7886579 7886614 36 + 0.377 0.207 -1.173
ENSG00000124275 E031 73.5302489 0.0003593613 1.675459e-02 4.439683e-02 5 7886615 7886703 89 + 1.839 1.736 -0.347
ENSG00000124275 E032 111.9651772 0.0063999287 3.668805e-01 5.112160e-01 5 7889095 7889275 181 + 2.005 1.974 -0.104
ENSG00000124275 E033 2.9851988 0.0056828179 6.961180e-01 7.965578e-01 5 7890261 7890345 85 + 0.533 0.610 0.351
ENSG00000124275 E034 3.1795886 0.0051574755 4.403044e-01 5.819863e-01 5 7890346 7890412 67 + 0.533 0.671 0.614
ENSG00000124275 E035 0.7363589 0.0154311557 2.481917e-01 3.837955e-01 5 7891369 7891371 3 + 0.270 0.000 -12.267
ENSG00000124275 E036 70.3703456 0.0005336100 7.299928e-01 8.220490e-01 5 7891372 7891414 43 + 1.792 1.824 0.108
ENSG00000124275 E037 127.7662886 0.0064564203 9.763568e-01 9.892176e-01 5 7892727 7892913 187 + 2.050 2.068 0.063
ENSG00000124275 E038 0.5879639 0.0198208020 9.382718e-01 9.652189e-01 5 7892914 7893175 262 + 0.181 0.208 0.250
ENSG00000124275 E039 1.8466062 0.1192862527 1.416502e-01 2.502981e-01 5 7893507 7893650 144 + 0.308 0.613 1.588
ENSG00000124275 E040 115.1173746 0.0044373375 9.075701e-01 9.453342e-01 5 7895734 7895852 119 + 2.004 2.026 0.075
ENSG00000124275 E041 1.1019577 0.3019873048 7.199221e-01 8.146250e-01 5 7896437 7896863 427 + 0.270 0.350 0.524
ENSG00000124275 E042 107.0822683 0.0024274978 9.526027e-01 9.743214e-01 5 7896864 7896956 93 + 1.974 1.995 0.070
ENSG00000124275 E043 139.9878422 0.0043276926 1.274856e-01 2.306538e-01 5 7897065 7897247 183 + 2.069 2.152 0.276
ENSG00000124275 E044 48.6931230 0.0155412410 9.170594e-01 9.515977e-01 5 7899914 7899914 1 + 1.633 1.653 0.068
ENSG00000124275 E045 239.2681668 0.0020326135 1.055593e-08 1.295368e-07 5 7899915 7900457 543 + 2.269 2.458 0.632
ENSG00000124275 E046 114.1575511 0.0010654626 2.376554e-38 7.405116e-36 5 7900458 7901042 585 + 1.828 2.305 1.600
ENSG00000124275 E047 9.7644291 0.0017929835 3.822145e-09 5.086715e-08 5 7901043 7901066 24 + 0.725 1.352 2.321
ENSG00000124275 E048 6.1496277 0.0026887463 3.344576e-07 3.064074e-06 5 7901067 7901128 62 + 0.533 1.180 2.552
ENSG00000124275 E049 0.5911862 0.0183997189 3.586747e-01 5.030528e-01 5 7904049 7904162 114 + 0.228 0.000 -11.960
ENSG00000124275 E050 0.2966881 0.0273730068 1.000000e+00   5 7905747 7906025 279 + 0.129 0.000 -10.983