ENSG00000124214

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340954 ENSG00000124214 HEK293_OSMI2_2hA HEK293_TMG_2hB STAU1 protein_coding protein_coding 54.05053 54.81226 63.31091 2.838839 1.637285 0.20792 3.094254 1.647794 5.438918 1.6477938 0.3423151 1.7167052 0.05670417 0.02956667 0.08583333 0.05626667 1.341337e-01 7.108808e-05 FALSE TRUE
ENST00000347458 ENSG00000124214 HEK293_OSMI2_2hA HEK293_TMG_2hB STAU1 protein_coding protein_coding 54.05053 54.81226 63.31091 2.838839 1.637285 0.20792 4.838064 5.792803 5.369912 1.7904469 0.2825057 -0.1091674 0.09033333 0.10853333 0.08500000 -0.02353333 9.172137e-01 7.108808e-05 FALSE TRUE
ENST00000360426 ENSG00000124214 HEK293_OSMI2_2hA HEK293_TMG_2hB STAU1 protein_coding protein_coding 54.05053 54.81226 63.31091 2.838839 1.637285 0.20792 29.523341 24.180469 37.878846 2.1642697 1.6947594 0.6473345 0.54054583 0.43956667 0.59773333 0.15816667 7.108808e-05 7.108808e-05 FALSE TRUE
ENST00000371828 ENSG00000124214 HEK293_OSMI2_2hA HEK293_TMG_2hB STAU1 protein_coding protein_coding 54.05053 54.81226 63.31091 2.838839 1.637285 0.20792 9.540823 14.452508 9.173067 1.4709087 0.5590459 -0.6552698 0.18061250 0.26263333 0.14550000 -0.11713333 2.639783e-04 7.108808e-05 FALSE TRUE
ENST00000371856 ENSG00000124214 HEK293_OSMI2_2hA HEK293_TMG_2hB STAU1 protein_coding protein_coding 54.05053 54.81226 63.31091 2.838839 1.637285 0.20792 4.834655 5.749030 4.251900 0.6669093 0.4911291 -0.4343290 0.09123750 0.10496667 0.06683333 -0.03813333 9.174231e-02 7.108808e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124214 E001 6.187214 0.0026387524 4.440126e-04 1.943775e-03 20 49113339 49113340 2 - 0.531 1.038 2.049
ENSG00000124214 E002 6.745000 0.0026569616 1.031527e-04 5.366460e-04 20 49113341 49113347 7 - 0.531 1.078 2.195
ENSG00000124214 E003 141.341201 0.0015660638 4.175266e-34 9.587777e-32 20 49113348 49113522 175 - 1.831 2.337 1.697
ENSG00000124214 E004 2673.820755 0.0040047870 2.235146e-13 6.051760e-12 20 49113523 49114893 1371 - 3.307 3.520 0.709
ENSG00000124214 E005 428.280890 0.0007475468 8.161113e-02 1.620801e-01 20 49115782 49115867 86 - 2.627 2.642 0.049
ENSG00000124214 E006 486.076286 0.0001318780 1.247157e-02 3.466811e-02 20 49117126 49117248 123 - 2.685 2.697 0.040
ENSG00000124214 E007 743.157508 0.0001404753 7.935938e-09 9.968436e-08 20 49117777 49118096 320 - 2.887 2.862 -0.083
ENSG00000124214 E008 319.168436 0.0021587203 9.827546e-04 3.900853e-03 20 49118333 49118408 76 - 2.531 2.486 -0.149
ENSG00000124214 E009 459.794145 0.0001490029 6.131108e-08 6.490752e-07 20 49119982 49120128 147 - 2.685 2.647 -0.129
ENSG00000124214 E010 479.023927 0.0002977168 1.799732e-03 6.598808e-03 20 49123092 49123229 138 - 2.685 2.682 -0.008
ENSG00000124214 E011 245.602746 0.0004574451 3.340098e-01 4.777725e-01 20 49123230 49123235 6 - 2.380 2.409 0.096
ENSG00000124214 E012 576.520329 0.0010383710 2.636213e-02 6.467087e-02 20 49124375 49124587 213 - 2.761 2.765 0.014
ENSG00000124214 E013 23.304903 0.0011629031 5.547911e-02 1.188091e-01 20 49124588 49124605 18 - 1.432 1.347 -0.296
ENSG00000124214 E014 302.046606 0.0048252489 6.133607e-02 1.288813e-01 20 49135833 49135931 99 - 2.494 2.469 -0.083
ENSG00000124214 E015 400.958891 0.0048524684 1.314570e-05 8.492169e-05 20 49151582 49151747 166 - 2.659 2.545 -0.378
ENSG00000124214 E016 369.746674 0.0042424063 3.494409e-09 4.684774e-08 20 49153933 49154071 139 - 2.645 2.482 -0.543
ENSG00000124214 E017 3.256337 0.1250814127 9.690284e-01 9.846310e-01 20 49158437 49158497 61 - 0.600 0.658 0.250
ENSG00000124214 E018 8.999009 0.0296833473 1.423674e-01 2.512653e-01 20 49158939 49159146 208 - 1.071 0.925 -0.541
ENSG00000124214 E019 42.205658 0.0152125626 7.690863e-01 8.508093e-01 20 49165997 49166285 289 - 1.623 1.649 0.086
ENSG00000124214 E020 222.418734 0.0095832774 5.015031e-04 2.165430e-03 20 49174195 49174269 75 - 2.412 2.280 -0.439
ENSG00000124214 E021 27.440937 0.0079601118 3.487588e-02 8.141273e-02 20 49179122 49179244 123 - 1.511 1.398 -0.389
ENSG00000124214 E022 229.753982 0.0028412508 2.142187e-11 4.225204e-10 20 49188116 49188378 263 - 2.447 2.264 -0.610