ENSG00000124207

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262982 ENSG00000124207 HEK293_OSMI2_2hA HEK293_TMG_2hB CSE1L protein_coding protein_coding 102.4691 39.53274 165.9588 5.452019 5.267682 2.069427 89.74638 30.123640 147.317 2.453325 4.838786 2.289575 0.85173750 0.7729000 0.8876 0.1147000 1.973197e-02 7.218904e-29 FALSE TRUE
ENST00000469700 ENSG00000124207 HEK293_OSMI2_2hA HEK293_TMG_2hB CSE1L protein_coding processed_transcript 102.4691 39.53274 165.9588 5.452019 5.267682 2.069427 2.65257 8.074974 0.000 3.163940 0.000000 -9.659099 0.06555833 0.1913667 0.0000 -0.1913667 7.218904e-29 7.218904e-29 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124207 E001 0.0000000       20 49046198 49046245 48 +      
ENSG00000124207 E002 0.3289534 0.0318773376 2.871421e-01   20 49046246 49046273 28 + 0.061 0.230 2.198
ENSG00000124207 E003 0.4741261 0.0213437465 5.286236e-01 6.615373e-01 20 49046274 49046290 17 + 0.115 0.230 1.199
ENSG00000124207 E004 0.6192988 0.0222182861 7.538355e-01 8.396303e-01 20 49046291 49046294 4 + 0.163 0.230 0.614
ENSG00000124207 E005 1.2063323 0.1071891819 7.014191e-01 8.006033e-01 20 49046295 49046297 3 + 0.314 0.230 -0.604
ENSG00000124207 E006 1.8038612 0.0073482269 3.103769e-01 4.527707e-01 20 49046298 49046298 1 + 0.427 0.230 -1.261
ENSG00000124207 E007 4.9394201 0.0036066958 3.418460e-02 8.011394e-02 20 49046299 49046311 13 + 0.757 0.379 -1.756
ENSG00000124207 E008 313.0246100 0.0187350437 4.301496e-07 3.854804e-06 20 49046312 49046423 112 + 2.461 2.100 -1.205
ENSG00000124207 E009 454.2200499 0.0284330951 2.523777e-04 1.185201e-03 20 49058453 49058548 96 + 2.615 2.318 -0.990
ENSG00000124207 E010 314.3253553 0.0144779841 2.393446e-05 1.458541e-04 20 49063202 49063228 27 + 2.452 2.190 -0.875
ENSG00000124207 E011 532.1381160 0.0055126262 1.510987e-10 2.585789e-09 20 49063229 49063344 116 + 2.679 2.424 -0.848
ENSG00000124207 E012 614.8541823 0.0053588331 3.734832e-13 9.795829e-12 20 49066192 49066293 102 + 2.745 2.462 -0.944
ENSG00000124207 E013 663.8655424 0.0013508846 2.391058e-27 3.201263e-25 20 49066365 49066510 146 + 2.777 2.511 -0.885
ENSG00000124207 E014 590.9761966 0.0005782047 8.868553e-41 3.224800e-38 20 49067190 49067280 91 + 2.730 2.433 -0.990
ENSG00000124207 E015 628.6993002 0.0016074074 1.456970e-22 1.237196e-20 20 49068715 49068822 108 + 2.751 2.499 -0.839
ENSG00000124207 E016 540.3941165 0.0040833698 5.136200e-11 9.525577e-10 20 49070205 49070297 93 + 2.682 2.452 -0.766
ENSG00000124207 E017 906.4800737 0.0034264593 1.465664e-11 2.970003e-10 20 49072286 49072453 168 + 2.902 2.703 -0.663
ENSG00000124207 E018 788.5259921 0.0050958606 1.987858e-06 1.547285e-05 20 49072568 49072697 130 + 2.837 2.673 -0.544
ENSG00000124207 E019 662.1625784 0.0057901470 3.264485e-05 1.924947e-04 20 49074785 49074850 66 + 2.759 2.606 -0.509
ENSG00000124207 E020 672.6540373 0.0038657544 2.138541e-04 1.023495e-03 20 49075318 49075427 110 + 2.759 2.650 -0.361
ENSG00000124207 E021 663.2433590 0.0048297502 5.905902e-03 1.836266e-02 20 49075428 49075520 93 + 2.748 2.664 -0.279
ENSG00000124207 E022 605.6882249 0.0041334297 1.880851e-02 4.891338e-02 20 49076980 49077064 85 + 2.705 2.642 -0.211
ENSG00000124207 E023 477.7618942 0.0068892029 4.063907e-01 5.500429e-01 20 49078561 49078622 62 + 2.593 2.576 -0.057
ENSG00000124207 E024 727.3062967 0.0025905899 9.658828e-02 1.852436e-01 20 49084026 49084162 137 + 2.778 2.752 -0.087
ENSG00000124207 E025 681.5526241 0.0002373645 2.379134e-03 8.395855e-03 20 49085283 49085386 104 + 2.750 2.723 -0.090
ENSG00000124207 E026 704.9497649 0.0003439317 2.500581e-01 3.859822e-01 20 49088009 49088106 98 + 2.758 2.766 0.026
ENSG00000124207 E027 989.6680471 0.0004801439 2.787366e-02 6.776615e-02 20 49089247 49089397 151 + 2.909 2.899 -0.030
ENSG00000124207 E028 1075.3426057 0.0005068302 4.168033e-02 9.415386e-02 20 49089538 49089746 209 + 2.929 2.992 0.209
ENSG00000124207 E029 430.2735955 0.0001524987 3.299338e-05 1.942777e-04 20 49090742 49090762 21 + 2.520 2.636 0.387
ENSG00000124207 E030 625.0587486 0.0003666291 3.658391e-13 9.607307e-12 20 49090763 49090839 77 + 2.668 2.833 0.546
ENSG00000124207 E031 663.9016294 0.0007538487 3.781939e-13 9.912520e-12 20 49090937 49091022 86 + 2.691 2.867 0.587
ENSG00000124207 E032 569.7281930 0.0001552366 5.632274e-37 1.599726e-34 20 49092046 49092127 82 + 2.602 2.853 0.835
ENSG00000124207 E033 899.1861673 0.0036855256 3.964401e-13 1.035637e-11 20 49094140 49094286 147 + 2.796 3.059 0.873
ENSG00000124207 E034 31.9049915 0.0193281376 9.009181e-01 9.408055e-01 20 49094478 49094731 254 + 1.421 1.468 0.162
ENSG00000124207 E035 1488.6393565 0.0126321094 6.895344e-08 7.225123e-07 20 49094732 49094963 232 + 2.993 3.318 1.079
ENSG00000124207 E036 73.3897631 0.0019866018 2.310717e-06 1.773306e-05 20 49096176 49096200 25 + 1.715 1.983 0.904
ENSG00000124207 E037 51.9181158 0.0004464252 2.675073e-07 2.500929e-06 20 49096201 49096227 27 + 1.556 1.862 1.038
ENSG00000124207 E038 79.3717369 0.0011936382 4.713151e-10 7.410510e-09 20 49096228 49096348 121 + 1.734 2.050 1.065
ENSG00000124207 E039 1183.2172020 0.0144130369 6.419476e-12 1.378699e-10 20 49096349 49096960 612 + 2.850 3.286 1.451