ENSG00000124201

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371752 ENSG00000124201 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNFX1 protein_coding protein_coding 3.365196 3.360978 3.440968 0.2065839 0.05420765 0.03383382 0.4918905 1.16398990 0.3096718 1.015930332 0.2011342 -1.8767567 0.1442250 0.3276333 0.09020000 -0.23743333 0.92896423 0.0009968393 FALSE  
ENST00000396105 ENSG00000124201 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNFX1 protein_coding protein_coding 3.365196 3.360978 3.440968 0.2065839 0.05420765 0.03383382 2.6411498 1.91787337 2.8506028 0.961250300 0.2191565 0.5693089 0.7864667 0.5904333 0.82853333 0.23810000 0.90990558 0.0009968393 FALSE  
MSTRG.20833.1 ENSG00000124201 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNFX1 protein_coding   3.365196 3.360978 3.440968 0.2065839 0.05420765 0.03383382 0.1037875 0.05882313 0.2363418 0.005294654 0.0169445 1.8396964 0.0310875 0.0175000 0.06856667 0.05106667 0.02975327 0.0009968393 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124201 E001 0.0000000       20 49235909 49235975 67 -      
ENSG00000124201 E002 2.2016064 0.0101674361 1.787831e-02 4.687681e-02 20 49237946 49238942 997 - 0.213 0.638 2.401
ENSG00000124201 E003 3.0601481 0.0061827778 5.109971e-01 6.461200e-01 20 49238943 49239300 358 - 0.549 0.669 0.534
ENSG00000124201 E004 1.6962749 0.1195346975 5.987272e-01 7.202724e-01 20 49241810 49241923 114 - 0.356 0.480 0.667
ENSG00000124201 E005 0.3697384 0.0252372838 2.002523e-01 3.265353e-01 20 49244585 49244752 168 - 0.000 0.222 10.665
ENSG00000124201 E006 0.0000000       20 49245897 49245899 3 -      
ENSG00000124201 E007 162.4666889 0.0097428791 7.107704e-10 1.085126e-08 20 49245900 49247099 1200 - 2.013 2.336 1.080
ENSG00000124201 E008 293.9645361 0.0016156704 5.874235e-03 1.828161e-02 20 49247100 49249711 2612 - 2.423 2.507 0.280
ENSG00000124201 E009 21.5678220 0.0009002823 9.644814e-04 3.837084e-03 20 49251527 49251622 96 - 1.456 1.240 -0.753
ENSG00000124201 E010 22.9161247 0.0011515015 3.465174e-02 8.098631e-02 20 49252720 49252830 111 - 1.441 1.316 -0.434
ENSG00000124201 E011 25.9263567 0.0007789271 4.060126e-01 5.496634e-01 20 49253666 49253811 146 - 1.446 1.416 -0.105
ENSG00000124201 E012 26.4759801 0.0323374974 2.947675e-01 4.358770e-01 20 49254495 49254649 155 - 1.475 1.401 -0.254
ENSG00000124201 E013 27.1124318 0.0007517351 5.852454e-02 1.241037e-01 20 49255808 49255932 125 - 1.497 1.399 -0.339
ENSG00000124201 E014 15.3161213 0.0014655902 2.944061e-01 4.355092e-01 20 49255933 49255947 15 - 1.243 1.177 -0.232
ENSG00000124201 E015 1.2156792 0.0140051163 2.588485e-01 3.961712e-01 20 49255948 49255978 31 - 0.213 0.427 1.399
ENSG00000124201 E016 40.0908466 0.0006840426 5.772514e-01 7.025295e-01 20 49257417 49257664 248 - 1.612 1.607 -0.018
ENSG00000124201 E017 21.4348672 0.0057647094 9.405493e-01 9.666590e-01 20 49260463 49260577 115 - 1.328 1.358 0.102
ENSG00000124201 E018 18.4768310 0.0010714547 4.919275e-01 6.291674e-01 20 49263334 49263483 150 - 1.301 1.272 -0.103
ENSG00000124201 E019 17.4757367 0.0056599211 2.454098e-01 3.805155e-01 20 49264716 49264864 149 - 1.301 1.224 -0.273
ENSG00000124201 E020 15.8768531 0.0117401663 1.411479e-01 2.496138e-01 20 49266135 49266266 132 - 1.280 1.160 -0.426
ENSG00000124201 E021 117.2398800 0.0094132524 2.995455e-06 2.241586e-05 20 49269942 49271750 1809 - 2.175 1.962 -0.712
ENSG00000124201 E022 15.7572760 0.0051515068 2.511146e-05 1.521895e-04 20 49275779 49275879 101 - 1.377 1.016 -1.285
ENSG00000124201 E023 5.9650986 0.0396347685 1.866329e-02 4.859273e-02 20 49275880 49275887 8 - 0.980 0.642 -1.338
ENSG00000124201 E024 0.1472490 0.0432059864 4.898969e-01   20 49277930 49278020 91 - 0.120 0.000 -10.278
ENSG00000124201 E025 8.7843009 0.0317724844 3.460597e-04 1.564267e-03 20 49278021 49278426 406 - 1.175 0.702 -1.788