ENSG00000124177

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373233 ENSG00000124177 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD6 protein_coding protein_coding 6.826092 2.654878 9.01438 0.3191545 0.3448588 1.759758 4.5995057 2.2730443 6.0304337 0.31722887 0.20044314 1.403693 0.70557500 0.85316667 0.67003333 -0.183133333 0.010868801 0.001004453 FALSE TRUE
ENST00000480022 ENSG00000124177 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD6 protein_coding processed_transcript 6.826092 2.654878 9.01438 0.3191545 0.3448588 1.759758 0.4302272 0.1754248 0.6094214 0.03338037 0.06164446 1.740087 0.06875833 0.06503333 0.06746667 0.002433333 1.000000000 0.001004453 FALSE TRUE
MSTRG.20713.4 ENSG00000124177 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD6 protein_coding   6.826092 2.654878 9.01438 0.3191545 0.3448588 1.759758 0.4734793 0.0000000 0.9100452 0.00000000 0.28761167 6.523633 0.05214167 0.00000000 0.10266667 0.102666667 0.001004453 0.001004453 FALSE TRUE
MSTRG.20713.6 ENSG00000124177 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD6 protein_coding   6.826092 2.654878 9.01438 0.3191545 0.3448588 1.759758 0.4685897 0.0000000 0.4288420 0.00000000 0.34968754 5.455630 0.06525833 0.00000000 0.04773333 0.047733333 0.539461726 0.001004453 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124177 E001 320.5412385 0.0069919444 4.503185e-23 4.024127e-21 20 41402083 41404522 2440 - 2.283 2.732 1.494
ENSG00000124177 E002 67.5344640 0.0032402616 8.232561e-04 3.342622e-03 20 41404523 41404805 283 - 1.698 1.933 0.792
ENSG00000124177 E003 73.9690620 0.0051202434 4.857935e-03 1.553694e-02 20 41404806 41405052 247 - 1.748 1.960 0.716
ENSG00000124177 E004 88.4019379 0.0053521900 5.714421e-02 1.217148e-01 20 41405053 41405489 437 - 1.846 2.005 0.532
ENSG00000124177 E005 40.7518828 0.0107195019 3.024404e-01 4.443168e-01 20 41412144 41412263 120 - 1.526 1.660 0.459
ENSG00000124177 E006 57.4385444 0.0039158328 1.795625e-01 3.005962e-01 20 41413324 41413515 192 - 1.669 1.804 0.459
ENSG00000124177 E007 14.7455268 0.0012559999 7.801982e-01 8.587194e-01 20 41413516 41414946 1431 - 1.133 1.162 0.105
ENSG00000124177 E008 2.7023446 0.0058453355 3.353553e-02 7.884639e-02 20 41414947 41414981 35 - 0.594 0.208 -2.252
ENSG00000124177 E009 1.8573447 0.0927030966 5.542887e-01 6.832965e-01 20 41414982 41415065 84 - 0.436 0.349 -0.486
ENSG00000124177 E010 81.6321870 0.0003170144 3.942583e-01 5.381238e-01 20 41415186 41415638 453 - 1.830 1.927 0.327
ENSG00000124177 E011 48.5897073 0.0156499780 4.778784e-01 6.163688e-01 20 41416588 41416794 207 - 1.598 1.729 0.446
ENSG00000124177 E012 50.0807822 0.0236754563 7.864306e-01 8.632367e-01 20 41417198 41417349 152 - 1.620 1.717 0.332
ENSG00000124177 E013 218.1172506 0.0031201051 7.842831e-02 1.569652e-01 20 41420508 41422079 1572 - 2.278 2.279 0.002
ENSG00000124177 E014 42.6928217 0.0009978164 2.181846e-01 3.482196e-01 20 41423492 41423700 209 - 1.582 1.565 -0.060
ENSG00000124177 E015 25.9414688 0.0309944244 7.716710e-03 2.306721e-02 20 41425178 41425259 82 - 1.423 1.166 -0.899
ENSG00000124177 E016 28.5370139 0.0096673646 1.026583e-01 1.945571e-01 20 41425260 41425389 130 - 1.431 1.342 -0.310
ENSG00000124177 E017 11.1353032 0.0024487124 1.057082e-01 1.991715e-01 20 41425390 41425394 5 - 1.061 0.923 -0.510
ENSG00000124177 E018 16.7433373 0.0028112693 9.042355e-02 1.757909e-01 20 41426093 41426141 49 - 1.217 1.103 -0.408
ENSG00000124177 E019 12.3135334 0.0015706513 2.333770e-01 3.664136e-01 20 41426142 41426153 12 - 1.086 1.010 -0.280
ENSG00000124177 E020 22.5784924 0.0009190310 1.002547e-01 1.908725e-01 20 41437274 41437332 59 - 1.329 1.246 -0.292
ENSG00000124177 E021 15.6396791 0.0027275220 2.137661e-01 3.429625e-01 20 41437333 41437334 2 - 1.175 1.104 -0.255
ENSG00000124177 E022 28.0906522 0.0049715669 3.998674e-02 9.101182e-02 20 41440000 41440129 130 - 1.432 1.315 -0.404
ENSG00000124177 E023 27.5425765 0.0007215348 3.200451e-01 4.631413e-01 20 41445665 41445768 104 - 1.403 1.387 -0.056
ENSG00000124177 E024 26.2965430 0.0008188828 1.974877e-02 5.095743e-02 20 41447882 41447971 90 - 1.406 1.275 -0.456
ENSG00000124177 E025 36.3708280 0.0005481697 2.845016e-03 9.809263e-03 20 41450946 41451105 160 - 1.548 1.398 -0.516
ENSG00000124177 E026 42.8698354 0.0005203130 2.985508e-05 1.777596e-04 20 41451826 41452025 200 - 1.629 1.408 -0.755
ENSG00000124177 E027 42.8694491 0.0005265799 1.170411e-07 1.174049e-06 20 41452740 41452942 203 - 1.641 1.328 -1.074
ENSG00000124177 E028 32.9083328 0.0006347849 6.321501e-05 3.471777e-04 20 41454626 41454736 111 - 1.524 1.275 -0.861
ENSG00000124177 E029 41.4022872 0.0005277253 6.797128e-04 2.824885e-03 20 41455800 41455979 180 - 1.605 1.438 -0.571
ENSG00000124177 E030 33.9402771 0.0006351824 2.819881e-02 6.840967e-02 20 41457264 41457428 165 - 1.505 1.408 -0.334
ENSG00000124177 E031 1.5530531 0.1199105805 1.440569e-01 2.535283e-01 20 41473023 41473321 299 - 0.270 0.605 1.812
ENSG00000124177 E032 39.6456275 0.0005389884 5.627039e-02 1.201860e-01 20 41473322 41473517 196 - 1.566 1.502 -0.221
ENSG00000124177 E033 46.4343932 0.0006992257 1.302053e-01 2.344531e-01 20 41483309 41483519 211 - 1.623 1.593 -0.105
ENSG00000124177 E034 51.8455062 0.0004646730 7.704304e-02 1.547551e-01 20 41484352 41484607 256 - 1.672 1.632 -0.137
ENSG00000124177 E035 36.8078187 0.0006094235 2.319874e-03 8.213445e-03 20 41487665 41487808 144 - 1.552 1.398 -0.530
ENSG00000124177 E036 32.3636252 0.0007012011 1.540868e-01 2.672190e-01 20 41488428 41488512 85 - 1.471 1.429 -0.147
ENSG00000124177 E037 32.4509368 0.0006035076 2.936540e-02 7.070829e-02 20 41488513 41488604 92 - 1.486 1.387 -0.342
ENSG00000124177 E038 43.2518874 0.0004814841 8.084874e-03 2.399547e-02 20 41489778 41490021 244 - 1.611 1.502 -0.372
ENSG00000124177 E039 22.2754993 0.0059307657 3.283562e-01 4.718410e-01 20 41491698 41491819 122 - 1.318 1.289 -0.102
ENSG00000124177 E040 26.0893535 0.0044809311 1.043900e-01 1.971721e-01 20 41493538 41493672 135 - 1.394 1.316 -0.272
ENSG00000124177 E041 25.9961677 0.0016285584 1.048997e-01 1.979494e-01 20 41493858 41493944 87 - 1.388 1.316 -0.251
ENSG00000124177 E042 1.1135859 0.0122233805 5.179773e-01 6.522816e-01 20 41496809 41497383 575 - 0.308 0.208 -0.748
ENSG00000124177 E043 27.6475620 0.0031079468 1.539410e-03 5.764138e-03 20 41497384 41497501 118 - 1.442 1.230 -0.739
ENSG00000124177 E044 0.8178402 0.1412925847 1.937036e-02 5.013606e-02 20 41497502 41498167 666 - 0.069 0.535 3.816
ENSG00000124177 E045 18.2366165 0.0011482437 1.919557e-01 3.162239e-01 20 41498168 41498226 59 - 1.244 1.180 -0.226
ENSG00000124177 E046 19.1138225 0.0009422300 6.917003e-02 1.419955e-01 20 41499295 41499357 63 - 1.273 1.162 -0.392
ENSG00000124177 E047 35.3548601 0.0006188774 8.937697e-03 2.612228e-02 20 41512846 41512995 150 - 1.532 1.408 -0.428
ENSG00000124177 E048 29.5399400 0.0024316932 3.186522e-03 1.081619e-02 20 41514805 41514919 115 - 1.469 1.288 -0.625
ENSG00000124177 E049 14.9696941 0.0171428816 1.389745e-01 2.466882e-01 20 41514920 41514952 33 - 1.179 1.057 -0.440
ENSG00000124177 E050 24.3885114 0.0008726938 2.265356e-02 5.703263e-02 20 41533050 41533155 106 - 1.379 1.245 -0.465
ENSG00000124177 E051 57.6790765 0.0003913394 5.079757e-04 2.189884e-03 20 41533156 41533570 415 - 1.740 1.606 -0.454
ENSG00000124177 E052 13.5170379 0.0012543992 4.792331e-02 1.054904e-01 20 41551305 41551360 56 - 1.144 0.983 -0.586
ENSG00000124177 E053 1.2555494 0.0149845464 9.724296e-01 9.868061e-01 20 41564011 41564151 141 - 0.308 0.348 0.251
ENSG00000124177 E054 0.5879639 0.0199192638 1.000000e+00 1.000000e+00 20 41614709 41614773 65 - 0.181 0.208 0.249
ENSG00000124177 E055 9.8152719 0.0021790398 4.448218e-01 5.863671e-01 20 41618340 41618413 74 - 0.991 0.954 -0.137