ENSG00000124126

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371941 ENSG00000124126 HEK293_OSMI2_2hA HEK293_TMG_2hB PREX1 protein_coding protein_coding 2.120851 3.970389 1.780109 0.4126024 0.04547298 -1.152862 1.5135735 2.1060629 1.5502568 0.2234971 0.007538807 -0.439599 0.77896667 0.5377667 0.8720667 0.3343000 1.658092e-04 6.871695e-06 FALSE TRUE
ENST00000482556 ENSG00000124126 HEK293_OSMI2_2hA HEK293_TMG_2hB PREX1 protein_coding nonsense_mediated_decay 2.120851 3.970389 1.780109 0.4126024 0.04547298 -1.152862 0.2119950 0.7549237 0.0000000 0.1723303 0.000000000 -6.257244 0.07195417 0.1930333 0.0000000 -0.1930333 6.871695e-06 6.871695e-06 TRUE TRUE
ENST00000620554 ENSG00000124126 HEK293_OSMI2_2hA HEK293_TMG_2hB PREX1 protein_coding protein_coding 2.120851 3.970389 1.780109 0.4126024 0.04547298 -1.152862 0.3764943 1.1094023 0.1833512 0.2948212 0.047211309 -2.533433 0.13975833 0.2692000 0.1026000 -0.1666000 6.741317e-02 6.871695e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124126 E001 129.9505353 0.0048057013 2.668661e-11 5.182142e-10 20 48624252 48625927 1676 - 1.850 2.161 1.042
ENSG00000124126 E002 17.4596081 0.0031435799 7.140899e-03 2.158988e-02 20 48627548 48627615 68 - 1.040 1.302 0.933
ENSG00000124126 E003 17.2517879 0.0080081893 8.776965e-01 9.254370e-01 20 48627861 48627963 103 - 1.221 1.244 0.084
ENSG00000124126 E004 22.4660665 0.0016248787 4.751113e-01 6.138670e-01 20 48629449 48629621 173 - 1.372 1.328 -0.155
ENSG00000124126 E005 12.9407384 0.0023527964 4.312245e-01 5.737958e-01 20 48630728 48630794 67 - 1.057 1.144 0.313
ENSG00000124126 E006 17.7044787 0.0053111318 1.202352e-01 2.203304e-01 20 48632277 48632391 115 - 1.133 1.286 0.541
ENSG00000124126 E007 0.2965864 0.2217819216 4.804341e-01   20 48632392 48632495 104 - 0.000 0.169 9.771
ENSG00000124126 E008 20.3574989 0.0011838672 3.100328e-01 4.523942e-01 20 48632496 48632639 144 - 1.232 1.323 0.319
ENSG00000124126 E009 18.0919136 0.0032885632 6.916522e-01 7.930917e-01 20 48634676 48634775 100 - 1.221 1.263 0.151
ENSG00000124126 E010 25.1109212 0.0012994927 5.133333e-02 1.115233e-01 20 48636463 48636683 221 - 1.274 1.430 0.542
ENSG00000124126 E011 14.6444829 0.0346515731 1.410450e-01 2.494683e-01 20 48637711 48637752 42 - 1.022 1.221 0.713
ENSG00000124126 E012 24.2331396 0.0155300936 1.047306e-01 1.977149e-01 20 48639766 48639894 129 - 1.253 1.416 0.567
ENSG00000124126 E013 0.1472490 0.0426970873 2.745533e-01   20 48642113 48642167 55 - 0.156 0.000 -10.778
ENSG00000124126 E014 20.2958569 0.0011443138 7.183047e-02 1.463902e-01 20 48642168 48642258 91 - 1.185 1.342 0.553
ENSG00000124126 E015 20.9763434 0.0009394801 2.791896e-01 4.189009e-01 20 48642407 48642489 83 - 1.243 1.338 0.333
ENSG00000124126 E016 0.3289534 0.0286126333 6.634750e-01   20 48642490 48642738 249 - 0.156 0.095 -0.829
ENSG00000124126 E017 22.1737697 0.0008936674 3.263001e-01 4.697523e-01 20 48644409 48644497 89 - 1.372 1.307 -0.225
ENSG00000124126 E018 28.2081044 0.0007585097 7.563803e-02 1.525253e-01 20 48645851 48646057 207 - 1.508 1.401 -0.370
ENSG00000124126 E019 26.2921350 0.0008227781 8.550387e-02 1.682170e-01 20 48649300 48649576 277 - 1.478 1.370 -0.372
ENSG00000124126 E020 21.3039550 0.0015112764 4.060706e-01 5.497196e-01 20 48649996 48650206 211 - 1.347 1.292 -0.194
ENSG00000124126 E021 16.1700154 0.0013101832 9.612401e-01 9.795838e-01 20 48650894 48651055 162 - 1.197 1.201 0.015
ENSG00000124126 E022 16.8078653 0.0086629258 8.475263e-01 9.053256e-01 20 48651396 48651583 188 - 1.209 1.237 0.100
ENSG00000124126 E023 16.0611695 0.0098843636 4.695765e-02 1.037517e-01 20 48652586 48652706 121 - 1.321 1.143 -0.629
ENSG00000124126 E024 15.2099050 0.0139245289 5.946736e-02 1.257161e-01 20 48653361 48653497 137 - 1.293 1.114 -0.635
ENSG00000124126 E025 12.7418085 0.0423849725 3.547215e-01 4.990452e-01 20 48655290 48655375 86 - 1.172 1.073 -0.356
ENSG00000124126 E026 16.7302363 0.0032782788 1.743419e-01 2.938247e-01 20 48657040 48657188 149 - 1.284 1.174 -0.386
ENSG00000124126 E027 13.7932557 0.0377586806 3.077285e-01 4.499640e-01 20 48658136 48658228 93 - 1.221 1.102 -0.424
ENSG00000124126 E028 19.6579884 0.0091661073 3.099981e-02 7.391474e-02 20 48659919 48660061 143 - 1.396 1.216 -0.629
ENSG00000124126 E029 13.4806213 0.0114529208 2.009256e-01 3.273393e-01 20 48666283 48666355 73 - 1.209 1.088 -0.433
ENSG00000124126 E030 13.7857300 0.0017873944 4.274336e-02 9.607406e-02 20 48676193 48676268 76 - 1.253 1.079 -0.623
ENSG00000124126 E031 11.9778073 0.0015299732 5.466847e-02 1.174185e-01 20 48679360 48679409 50 - 1.197 1.022 -0.631
ENSG00000124126 E032 14.5081677 0.0012750536 1.088194e-01 2.037991e-01 20 48679651 48679754 104 - 1.253 1.121 -0.471
ENSG00000124126 E033 14.8369582 0.0032602121 4.872952e-02 1.069098e-01 20 48681235 48681335 101 - 1.274 1.105 -0.601
ENSG00000124126 E034 18.7832313 0.0010295415 1.520204e-03 5.702080e-03 20 48688657 48688804 148 - 1.418 1.181 -0.830
ENSG00000124126 E035 19.6549345 0.0183423441 1.052954e-02 3.004438e-02 20 48690947 48691096 150 - 1.438 1.204 -0.820
ENSG00000124126 E036 7.1763358 0.0028412045 1.250119e-02 3.473670e-02 20 48692323 48692671 349 - 0.606 0.957 1.409
ENSG00000124126 E037 21.2510542 0.0009368959 3.452913e-01 4.893944e-01 20 48692672 48692790 119 - 1.364 1.302 -0.217
ENSG00000124126 E038 17.2106372 0.0061673493 9.845003e-01 9.943839e-01 20 48700753 48700886 134 - 1.232 1.239 0.025
ENSG00000124126 E039 17.7140204 0.0018524383 8.966072e-01 9.379013e-01 20 48708260 48708421 162 - 1.232 1.251 0.070
ENSG00000124126 E040 14.1289464 0.0012594040 9.715508e-01 9.862154e-01 20 48726290 48726391 102 - 1.147 1.152 0.019
ENSG00000124126 E041 11.0331241 0.0018022110 8.870134e-01 9.317499e-01 20 48734546 48734650 105 - 1.057 1.051 -0.022
ENSG00000124126 E042 12.2845063 0.0016237293 6.191473e-01 7.366334e-01 20 48745025 48745147 123 - 1.119 1.079 -0.144
ENSG00000124126 E043 7.6415756 0.0095730274 6.654683e-03 2.032747e-02 20 48747809 48747880 72 - 1.089 0.771 -1.203
ENSG00000124126 E044 5.7385181 0.0730333060 7.282171e-03 2.195708e-02 20 48827642 48827999 358 - 1.058 0.595 -1.829