ENSG00000124104

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344780 ENSG00000124104 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX21 protein_coding processed_transcript 7.414297 13.94393 4.369469 0.5646937 0.456994 -1.671843 0.3458648 0.0000000 0.6132650 0.00000000 0.3114889 5.96177370 0.07729167 0.00000000 0.13573333 0.13573333 0.07655186 0.0001980242 FALSE TRUE
ENST00000372541 ENSG00000124104 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX21 protein_coding protein_coding 7.414297 13.94393 4.369469 0.5646937 0.456994 -1.671843 1.9330877 3.4769008 1.2021142 0.42139233 0.1485698 -1.52441965 0.25985417 0.24863333 0.27460000 0.02596667 0.79713806 0.0001980242 FALSE TRUE
ENST00000372542 ENSG00000124104 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX21 protein_coding protein_coding 7.414297 13.94393 4.369469 0.5646937 0.456994 -1.671843 1.2945321 2.0855524 0.2138589 0.18356051 0.1466331 -3.22666931 0.15535000 0.14976667 0.05056667 -0.09920000 0.22999641 0.0001980242 FALSE TRUE
ENST00000462307 ENSG00000124104 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX21 protein_coding protein_coding 7.414297 13.94393 4.369469 0.5646937 0.456994 -1.671843 0.2718469 1.1130179 0.0000000 1.11301792 0.0000000 -6.81123714 0.03242917 0.08013333 0.00000000 -0.08013333 0.98540615 0.0001980242 FALSE TRUE
ENST00000466252 ENSG00000124104 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX21 protein_coding processed_transcript 7.414297 13.94393 4.369469 0.5646937 0.456994 -1.671843 0.2800775 0.3967186 0.7029130 0.34751869 0.3013568 0.80969491 0.04525833 0.02690000 0.15103333 0.12413333 0.10863407 0.0001980242 FALSE FALSE
ENST00000486336 ENSG00000124104 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX21 protein_coding retained_intron 7.414297 13.94393 4.369469 0.5646937 0.456994 -1.671843 0.5003741 1.4506138 0.1604348 0.49447837 0.1604348 -3.09928263 0.05398750 0.10623333 0.03040000 -0.07583333 0.26159854 0.0001980242 FALSE TRUE
ENST00000491381 ENSG00000124104 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX21 protein_coding protein_coding 7.414297 13.94393 4.369469 0.5646937 0.456994 -1.671843 0.6454757 1.0058514 0.9754907 0.09726822 0.2443915 -0.04377519 0.10615417 0.07190000 0.23443333 0.16253333 0.03245590 0.0001980242 FALSE TRUE
MSTRG.20779.3 ENSG00000124104 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX21 protein_coding   7.414297 13.94393 4.369469 0.5646937 0.456994 -1.671843 1.3027720 3.1429648 0.3199708 0.17118916 0.3199708 -3.25629891 0.14157917 0.22520000 0.08013333 -0.14506667 0.18016243 0.0001980242 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000124104 E001 0.9577023 0.0137741355 1.309581e-01 0.2354792424 20 45833799 45833809 11 + 0.450 0.183 -1.800
ENSG00000124104 E002 2.3541686 0.0062261666 7.934398e-02 0.1584813402 20 45833810 45833819 10 + 0.667 0.379 -1.384
ENSG00000124104 E003 3.4174019 0.0048554747 6.761421e-02 0.1393891917 20 45833820 45833830 11 + 0.768 0.491 -1.213
ENSG00000124104 E004 6.9131502 0.0051396456 3.490002e-01 0.4932194156 20 45833831 45833851 21 + 0.885 0.771 -0.448
ENSG00000124104 E005 14.9290997 0.0093616023 1.943901e-01 0.3192735928 20 45833852 45833894 43 + 1.192 1.069 -0.443
ENSG00000124104 E006 17.3981608 0.0087551254 3.258969e-01 0.4693429647 20 45833895 45833940 46 + 1.225 1.140 -0.300
ENSG00000124104 E007 3.0634313 0.0253712192 1.306617e-02 0.0360643315 20 45833941 45834018 78 + 0.811 0.411 -1.793
ENSG00000124104 E008 1.6167525 0.0091320969 9.683713e-01 0.9842431102 20 45834019 45834135 117 + 0.345 0.347 0.010
ENSG00000124104 E009 2.2036828 0.0152923861 6.662816e-01 0.7737554400 20 45834136 45834150 15 + 0.345 0.439 0.527
ENSG00000124104 E010 8.6938895 0.0020841071 2.949618e-01 0.4360690402 20 45834151 45834200 50 + 0.978 0.862 -0.436
ENSG00000124104 E011 66.9134732 0.0043343932 9.148125e-02 0.1774465442 20 45834201 45834356 156 + 1.786 1.707 -0.267
ENSG00000124104 E012 76.6816596 0.0015567468 4.626560e-02 0.1025227916 20 45834357 45834468 112 + 1.846 1.766 -0.271
ENSG00000124104 E013 5.6273508 0.0033428122 6.872587e-01 0.7896347312 20 45834577 45834748 172 + 0.667 0.743 0.317
ENSG00000124104 E014 5.2908836 0.0033612340 8.245305e-01 0.8894579545 20 45834749 45834958 210 + 0.667 0.715 0.202
ENSG00000124104 E015 68.2628540 0.0004597086 3.726760e-01 0.5171007614 20 45834959 45835032 74 + 1.684 1.748 0.215
ENSG00000124104 E016 72.9393493 0.0003854574 4.710798e-01 0.6102240348 20 45835033 45835109 77 + 1.721 1.774 0.179
ENSG00000124104 E017 28.4140897 0.0252087078 8.214748e-01 0.8874299800 20 45835110 45835116 7 + 1.371 1.369 -0.006
ENSG00000124104 E018 3.0945878 0.0051602397 6.009295e-01 0.7221118422 20 45838268 45838360 93 + 0.450 0.558 0.522
ENSG00000124104 E019 4.0074396 0.0040043164 3.317363e-01 0.4753719969 20 45840322 45840447 126 + 0.720 0.579 -0.606
ENSG00000124104 E020 7.3246185 0.0024363041 4.891002e-01 0.6265963318 20 45840448 45840458 11 + 0.885 0.807 -0.304
ENSG00000124104 E021 103.9415787 0.0009670789 1.339711e-01 0.2396686583 20 45840639 45840780 142 + 1.850 1.933 0.279
ENSG00000124104 E022 362.4978676 0.0030596742 4.210038e-05 0.0002414141 20 45840781 45842032 1252 + 2.352 2.479 0.423
ENSG00000124104 E023 95.5947342 0.0003961406 2.085311e-06 0.0000161606 20 45842033 45843276 1244 + 2.010 1.839 -0.575