ENSG00000123992

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373963 ENSG00000123992 HEK293_OSMI2_2hA HEK293_TMG_2hB DNPEP protein_coding nonsense_mediated_decay 57.37407 95.34834 40.23746 4.332192 0.853217 -1.244461 15.367951 26.537707 10.225840 3.1193131 1.5499448 -1.3749577 0.25792083 0.27683333 0.25280000 -0.02403333 8.469572e-01 9.448919e-17 FALSE TRUE
ENST00000460963 ENSG00000123992 HEK293_OSMI2_2hA HEK293_TMG_2hB DNPEP protein_coding retained_intron 57.37407 95.34834 40.23746 4.332192 0.853217 -1.244461 2.659890 2.014833 3.188772 0.1653299 0.5031396 0.6597153 0.05658333 0.02123333 0.07880000 0.05756667 6.506585e-07 9.448919e-17 FALSE TRUE
ENST00000488881 ENSG00000123992 HEK293_OSMI2_2hA HEK293_TMG_2hB DNPEP protein_coding retained_intron 57.37407 95.34834 40.23746 4.332192 0.853217 -1.244461 2.007970 1.168578 2.640839 0.1015770 0.2096252 1.1694017 0.04327083 0.01233333 0.06546667 0.05313333 9.448919e-17 9.448919e-17   FALSE
ENST00000521459 ENSG00000123992 HEK293_OSMI2_2hA HEK293_TMG_2hB DNPEP protein_coding protein_coding 57.37407 95.34834 40.23746 4.332192 0.853217 -1.244461 6.607129 9.934816 5.107490 1.1924335 0.4884888 -0.9585084 0.11420417 0.10360000 0.12750000 0.02390000 5.922304e-01 9.448919e-17 FALSE FALSE
ENST00000523282 ENSG00000123992 HEK293_OSMI2_2hA HEK293_TMG_2hB DNPEP protein_coding protein_coding 57.37407 95.34834 40.23746 4.332192 0.853217 -1.244461 18.745896 36.232985 7.980167 0.5919056 1.7454119 -2.1814042 0.30715000 0.38110000 0.20036667 -0.18073333 3.466448e-02 9.448919e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123992 E001 69.3750180 0.0004669773 5.641187e-35 1.380757e-32 2 219372043 219373526 1484 - 2.113 1.574 -1.820
ENSG00000123992 E002 109.3878767 0.0002724273 1.562284e-20 1.064257e-18 2 219373527 219374193 667 - 2.193 1.856 -1.129
ENSG00000123992 E003 46.7758827 0.0007533357 7.372284e-01 8.274623e-01 2 219374194 219374195 2 - 1.605 1.582 -0.078
ENSG00000123992 E004 47.5917338 0.0008570105 7.383098e-01 8.282149e-01 2 219374196 219374196 1 - 1.611 1.589 -0.077
ENSG00000123992 E005 373.4222788 0.0007972966 4.139131e-04 1.827846e-03 2 219374197 219374342 146 - 2.409 2.500 0.304
ENSG00000123992 E006 331.3471078 0.0011986885 1.517504e-05 9.673494e-05 2 219374855 219374879 25 - 2.327 2.454 0.422
ENSG00000123992 E007 400.9192852 0.0001778181 1.269264e-07 1.263774e-06 2 219374880 219374923 44 - 2.418 2.535 0.392
ENSG00000123992 E008 517.3713126 0.0002040273 3.621473e-07 3.294172e-06 2 219374924 219375022 99 - 2.542 2.642 0.334
ENSG00000123992 E009 503.5789894 0.0008635758 2.062759e-03 7.419751e-03 2 219381335 219381436 102 - 2.553 2.625 0.239
ENSG00000123992 E010 3.9285260 0.0613512040 1.886105e-01 3.119883e-01 2 219381437 219381486 50 - 0.793 0.554 -1.014
ENSG00000123992 E011 363.6527684 0.0008641571 7.695502e-02 1.546209e-01 2 219381545 219381584 40 - 2.435 2.480 0.151
ENSG00000123992 E012 13.7854509 0.0013171341 6.140425e-15 2.086610e-13 2 219381585 219381779 195 - 1.523 0.825 -2.510
ENSG00000123992 E013 5.7819562 0.0054152964 9.161281e-05 4.825605e-04 2 219381792 219381802 11 - 1.099 0.595 -1.978
ENSG00000123992 E014 13.9823247 0.0013170171 1.730207e-10 2.931603e-09 2 219381803 219381978 176 - 1.467 0.891 -2.061
ENSG00000123992 E015 315.6812160 0.0010063936 3.110838e-02 7.411577e-02 2 219381979 219381997 19 - 2.361 2.422 0.201
ENSG00000123992 E016 537.4523587 0.0011785462 4.838437e-02 1.063024e-01 2 219381998 219382139 142 - 2.603 2.650 0.158
ENSG00000123992 E017 354.9226968 0.0006742121 1.677319e-02 4.443678e-02 2 219383131 219383204 74 - 2.413 2.473 0.201
ENSG00000123992 E018 210.9316658 0.0007941662 7.856268e-03 2.342008e-02 2 219383205 219383208 4 - 2.168 2.253 0.286
ENSG00000123992 E019 210.6256756 0.0020303618 1.062609e-01 2.000199e-01 2 219383209 219383214 6 - 2.189 2.248 0.197
ENSG00000123992 E020 364.9369435 0.0003305405 9.015698e-02 1.753644e-01 2 219384366 219384443 78 - 2.443 2.481 0.127
ENSG00000123992 E021 18.3338915 0.0026363092 8.339949e-14 2.399360e-12 2 219384444 219384573 130 - 1.599 0.991 -2.139
ENSG00000123992 E022 44.1560706 0.0069351505 7.923746e-23 6.904921e-21 2 219384586 219385153 568 - 1.979 1.330 -2.210
ENSG00000123992 E023 33.0254415 0.0078476781 1.380822e-15 5.126251e-14 2 219385154 219385423 270 - 1.829 1.242 -2.013
ENSG00000123992 E024 202.8504179 0.0005750211 9.554722e-01 9.760655e-01 2 219385424 219385430 7 - 2.222 2.219 -0.012
ENSG00000123992 E025 406.4685381 0.0004554490 1.716706e-01 2.903923e-01 2 219385431 219385531 101 - 2.496 2.525 0.099
ENSG00000123992 E026 287.6047912 0.0012179950 6.143015e-02 1.290417e-01 2 219385631 219385658 28 - 2.325 2.380 0.183
ENSG00000123992 E027 347.7609585 0.0011085632 1.786192e-01 2.994245e-01 2 219385659 219385706 48 - 2.422 2.458 0.118
ENSG00000123992 E028 8.4551127 0.0026667584 1.017952e-07 1.031989e-06 2 219385707 219385751 45 - 1.277 0.686 -2.217
ENSG00000123992 E029 8.4697753 0.0143182133 1.196129e-07 1.197691e-06 2 219385752 219385834 83 - 1.303 0.669 -2.380
ENSG00000123992 E030 265.7831185 0.0004142981 6.755662e-01 7.807997e-01 2 219385968 219385981 14 - 2.326 2.335 0.031
ENSG00000123992 E031 507.1465727 0.0006220900 9.277938e-01 9.585728e-01 2 219385982 219386098 117 - 2.616 2.613 -0.013
ENSG00000123992 E032 2.0723309 0.0291345688 6.821232e-02 1.404037e-01 2 219386204 219386285 82 - 0.650 0.323 -1.650
ENSG00000123992 E033 519.7671625 0.0009239703 1.985432e-01 3.243710e-01 2 219386286 219386411 126 - 2.648 2.617 -0.103
ENSG00000123992 E034 268.8902112 0.0002351513 7.684646e-03 2.298732e-02 2 219386665 219386681 17 - 2.393 2.322 -0.235
ENSG00000123992 E035 251.7683402 0.0002508292 6.026716e-03 1.868158e-02 2 219386682 219386686 5 - 2.368 2.293 -0.250
ENSG00000123992 E036 384.9621714 0.0004416726 2.207935e-02 5.584402e-02 2 219386687 219386778 92 - 2.535 2.481 -0.181
ENSG00000123992 E037 345.2019222 0.0019153068 7.656875e-02 1.540016e-01 2 219386892 219386948 57 - 2.488 2.434 -0.181
ENSG00000123992 E038 253.6501359 0.0037344940 2.189607e-01 3.491469e-01 2 219386949 219386980 32 - 2.350 2.302 -0.161
ENSG00000123992 E039 322.5493635 0.0055665157 1.497727e-01 2.613693e-01 2 219387070 219387163 94 - 2.463 2.404 -0.196
ENSG00000123992 E040 1.4298644 0.1013130014 4.573423e-01 5.976678e-01 2 219387278 219387575 298 - 0.437 0.286 -0.895
ENSG00000123992 E041 16.0541713 0.0155488244 3.193469e-01 4.624220e-01 2 219387576 219387758 183 - 1.220 1.110 -0.392
ENSG00000123992 E042 168.4637451 0.0070504927 1.704647e-01 2.887572e-01 2 219387759 219387932 174 - 2.190 2.120 -0.233
ENSG00000123992 E043 0.3697384 0.0274424043 7.527545e-01 8.388628e-01 2 219388702 219388748 47 - 0.000 0.136 8.674
ENSG00000123992 E044 0.7331471 0.0172671820 2.948072e-01 4.359154e-01 2 219388834 219388876 43 - 0.000 0.239 9.674
ENSG00000123992 E045 0.0000000       2 219393611 219393748 138 -      
ENSG00000123992 E046 0.0000000       2 219399440 219399500 61 -      
ENSG00000123992 E047 0.0000000       2 219399866 219399939 74 -      
ENSG00000123992 E048 0.0000000       2 219399940 219400022 83 -