ENSG00000123983

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357430 ENSG00000123983 HEK293_OSMI2_2hA HEK293_TMG_2hB ACSL3 protein_coding protein_coding 29.21079 9.060532 35.2656 0.5955312 1.52469 1.959411 9.057063 2.418034 13.043044 0.7180753 1.3273782 2.42652586 0.3232667 0.2619333 0.3679333 0.1060000 4.445242e-01 3.441624e-32 FALSE TRUE
ENST00000392066 ENSG00000123983 HEK293_OSMI2_2hA HEK293_TMG_2hB ACSL3 protein_coding protein_coding 29.21079 9.060532 35.2656 0.5955312 1.52469 1.959411 1.904169 2.314915 2.276073 0.6755372 0.6843435 -0.02430690 0.1305500 0.2495000 0.0664000 -0.1831000 2.521236e-02 3.441624e-32 FALSE TRUE
ENST00000421680 ENSG00000123983 HEK293_OSMI2_2hA HEK293_TMG_2hB ACSL3 protein_coding processed_transcript 29.21079 9.060532 35.2656 0.5955312 1.52469 1.959411 6.099808 1.528418 6.512479 0.7926777 1.1287789 2.08397264 0.1934250 0.1580000 0.1826000 0.0246000 8.553243e-01 3.441624e-32 FALSE FALSE
ENST00000680382 ENSG00000123983 HEK293_OSMI2_2hA HEK293_TMG_2hB ACSL3 protein_coding retained_intron 29.21079 9.060532 35.2656 0.5955312 1.52469 1.959411 5.240459 0.000000 7.651622 0.0000000 0.6205322 9.58150599 0.1165833 0.0000000 0.2165000 0.2165000 3.441624e-32 3.441624e-32 FALSE TRUE
ENST00000680424 ENSG00000123983 HEK293_OSMI2_2hA HEK293_TMG_2hB ACSL3 protein_coding processed_transcript 29.21079 9.060532 35.2656 0.5955312 1.52469 1.959411 3.258172 1.872777 1.784327 1.2124851 1.7843272 -0.06941937 0.1141500 0.2247667 0.0552000 -0.1695667 4.132691e-01 3.441624e-32 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123983 E001 0.1472490 0.0431732368 1.000000e+00   2 222860942 222860983 42 + 0.076 0.000 -9.841
ENSG00000123983 E002 0.1472490 0.0431732368 1.000000e+00   2 222860984 222860984 1 + 0.076 0.000 -10.550
ENSG00000123983 E003 0.9598804 0.0155069819 5.698274e-01 6.963438e-01 2 222860985 222861005 21 + 0.292 0.191 -0.795
ENSG00000123983 E004 1.5553330 0.0086739147 1.939474e-01 3.187539e-01 2 222861006 222861013 8 + 0.436 0.191 -1.644
ENSG00000123983 E005 2.8797695 0.0052948368 8.389297e-02 1.656377e-01 2 222861014 222861027 14 + 0.630 0.323 -1.562
ENSG00000123983 E006 8.4669666 0.0019459796 3.405212e-03 1.145330e-02 2 222861028 222861035 8 + 1.025 0.635 -1.534
ENSG00000123983 E007 61.0124848 0.0345020491 2.739518e-02 6.679711e-02 2 222861036 222861167 132 + 1.805 1.590 -0.729
ENSG00000123983 E008 73.5312574 0.0094571379 7.002960e-04 2.900058e-03 2 222861168 222861258 91 + 1.885 1.668 -0.731
ENSG00000123983 E009 0.0000000       2 222861261 222861422 162 +      
ENSG00000123983 E010 0.0000000       2 222861423 222861440 18 +      
ENSG00000123983 E011 0.0000000       2 222861441 222861562 122 +      
ENSG00000123983 E012 0.0000000       2 222861563 222861611 49 +      
ENSG00000123983 E013 0.0000000       2 222861612 222861627 16 +      
ENSG00000123983 E014 0.0000000       2 222861628 222861742 115 +      
ENSG00000123983 E015 0.0000000       2 222861743 222861751 9 +      
ENSG00000123983 E016 0.0000000       2 222865466 222865574 109 +      
ENSG00000123983 E017 0.0000000       2 222878026 222878159 134 +      
ENSG00000123983 E018 0.0000000       2 222881040 222881079 40 +      
ENSG00000123983 E019 62.6700853 0.0009832125 8.416694e-07 7.104743e-06 2 222887830 222887888 59 + 1.822 1.567 -0.865
ENSG00000123983 E020 0.0000000       2 222889817 222889862 46 +      
ENSG00000123983 E021 0.2987644 0.0272067276 6.552772e-01   2 222892264 222892301 38 + 0.141 0.000 -11.532
ENSG00000123983 E022 45.6398543 0.0013535417 3.922674e-07 3.541623e-06 2 222900674 222900780 107 + 1.702 1.384 -1.088
ENSG00000123983 E023 224.0690274 0.0021486646 2.003589e-04 9.653211e-04 2 222908733 222909084 352 + 2.341 2.232 -0.366
ENSG00000123983 E024 132.2988603 0.0016829027 4.394960e-02 9.829212e-02 2 222909085 222909150 66 + 2.100 2.039 -0.203
ENSG00000123983 E025 0.1482932 0.0414047113 1.720175e-01   2 222909616 222909738 123 + 0.000 0.191 13.071
ENSG00000123983 E026 0.1451727 0.0431352833 1.000000e+00   2 222910437 222911730 1294 + 0.076 0.000 -10.550
ENSG00000123983 E027 186.9840020 0.0002241649 4.726328e-05 2.678879e-04 2 222916319 222916496 178 + 2.261 2.160 -0.338
ENSG00000123983 E028 3.0825904 0.0178371270 8.645305e-01 9.166771e-01 2 222916497 222917687 1191 + 0.589 0.575 -0.063
ENSG00000123983 E029 0.5181333 0.0205845102 7.887215e-01 8.647344e-01 2 222917688 222918045 358 + 0.141 0.191 0.527
ENSG00000123983 E030 83.8004753 0.0003545247 1.616645e-02 4.309151e-02 2 222918046 222918069 24 + 1.911 1.824 -0.291
ENSG00000123983 E031 139.4510264 0.0002314469 6.071051e-04 2.559000e-03 2 222918070 222918155 86 + 2.134 2.036 -0.327
ENSG00000123983 E032 185.8321141 0.0023224097 1.293177e-02 3.575169e-02 2 222919064 222919202 139 + 2.252 2.180 -0.242
ENSG00000123983 E033 0.0000000       2 222920954 222921068 115 +      
ENSG00000123983 E034 221.1414490 0.0001828084 1.488667e-02 4.023464e-02 2 222921280 222921430 151 + 2.320 2.276 -0.149
ENSG00000123983 E035 1.4123503 0.0099323497 2.550464e-01 3.918462e-01 2 222921431 222922707 1277 + 0.404 0.191 -1.474
ENSG00000123983 E036 79.3911137 0.0003191957 4.952456e-01 6.320843e-01 2 222922708 222922709 2 + 1.869 1.859 -0.034
ENSG00000123983 E037 201.8608065 0.0009633638 7.283588e-02 1.480562e-01 2 222922710 222922831 122 + 2.279 2.244 -0.117
ENSG00000123983 E038 177.1466729 0.0002418493 1.304061e-01 2.347223e-01 2 222923078 222923149 72 + 2.219 2.193 -0.084
ENSG00000123983 E039 1.2598027 0.0342161312 9.187327e-01 9.526505e-01 2 222923150 222923385 236 + 0.333 0.323 -0.060
ENSG00000123983 E040 205.2637120 0.0030849315 9.088507e-01 9.460959e-01 2 222924456 222924595 140 + 2.266 2.289 0.077
ENSG00000123983 E041 0.8856842 0.0657787467 1.233280e-01 2.247133e-01 2 222924596 222924829 234 + 0.333 0.000 -13.145
ENSG00000123983 E042 266.0827024 0.0003378824 3.692376e-01 5.136731e-01 2 222927017 222927189 173 + 2.373 2.415 0.139
ENSG00000123983 E043 3.1928152 0.0310155856 4.561663e-01 5.966301e-01 2 222927190 222927242 53 + 0.629 0.506 -0.562
ENSG00000123983 E044 10.1773588 0.0330074510 7.507451e-02 1.516558e-01 2 222927243 222928861 1619 + 1.069 0.817 -0.950
ENSG00000123983 E045 219.0096495 0.0002271948 4.348345e-01 5.771169e-01 2 222928862 222928936 75 + 2.290 2.331 0.136
ENSG00000123983 E046 1.1501176 0.0135461712 9.101097e-01 9.468602e-01 2 222930611 222930620 10 + 0.292 0.323 0.204
ENSG00000123983 E047 334.1518583 0.0001816990 4.114335e-02 9.314997e-02 2 222930621 222930812 192 + 2.467 2.530 0.210
ENSG00000123983 E048 0.6611159 0.0251854292 9.908763e-01 9.984411e-01 2 222933018 222933165 148 + 0.197 0.191 -0.057
ENSG00000123983 E049 239.4413459 0.0002434912 3.737044e-03 1.240250e-02 2 222933166 222933280 115 + 2.314 2.406 0.308
ENSG00000123983 E050 0.1482932 0.0414047113 1.720175e-01   2 222933281 222933505 225 + 0.000 0.191 13.071
ENSG00000123983 E051 0.1482932 0.0414047113 1.720175e-01   2 222933506 222933693 188 + 0.000 0.191 13.071
ENSG00000123983 E052 0.2965864 0.1677943216 5.767061e-02   2 222933694 222934529 836 + 0.000 0.319 13.758
ENSG00000123983 E053 263.3716715 0.0029432164 2.827152e-06 2.128588e-05 2 222934530 222934687 158 + 2.323 2.501 0.594
ENSG00000123983 E054 97.5626765 0.0044454434 6.378929e-05 3.499968e-04 2 222941497 222941500 4 + 1.880 2.096 0.725
ENSG00000123983 E055 731.4456250 0.0043921722 1.436194e-04 7.192267e-04 2 222941501 222944639 3139 + 2.781 2.917 0.451