ENSG00000123737

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000243498 ENSG00000123737 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOSC9 protein_coding protein_coding 46.67926 23.07932 73.08636 1.588986 1.814134 1.662574 29.000893 15.730333 48.390090 0.7496451 1.9082032 1.6205437 0.62168750 0.68370000 0.66160000 -0.02210000 0.7547103693 2.870733e-14 FALSE  
ENST00000379663 ENSG00000123737 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOSC9 protein_coding protein_coding 46.67926 23.07932 73.08636 1.588986 1.814134 1.662574 6.577628 4.280720 7.782601 0.5492421 0.4726914 0.8608851 0.15374583 0.18413333 0.10646667 -0.07766667 0.0003813375 2.870733e-14 FALSE  
ENST00000513654 ENSG00000123737 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOSC9 protein_coding nonsense_mediated_decay 46.67926 23.07932 73.08636 1.588986 1.814134 1.662574 3.048821 1.027494 4.153439 0.1828748 0.2122171 2.0046730 0.06437917 0.04473333 0.05703333 0.01230000 0.5310709690 2.870733e-14 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123737 E001 0.2924217 0.0271962630 6.472436e-01   4 121801318 121801319 2 + 0.147 0.000 -10.998
ENSG00000123737 E002 0.2924217 0.0271962630 6.472436e-01   4 121801320 121801321 2 + 0.147 0.000 -10.990
ENSG00000123737 E003 0.4375944 0.0256680565 3.827448e-01 5.269114e-01 4 121801322 121801322 1 + 0.205 0.000 -11.574
ENSG00000123737 E004 0.4375944 0.0256680565 3.827448e-01 5.269114e-01 4 121801323 121801324 2 + 0.205 0.000 -11.574
ENSG00000123737 E005 15.4098854 0.0119204336 8.949466e-01 9.368729e-01 4 121801325 121801345 21 + 1.189 1.196 0.025
ENSG00000123737 E006 227.7825325 0.0022382753 5.809427e-02 1.233653e-01 4 121801346 121801490 145 + 2.351 2.278 -0.245
ENSG00000123737 E007 1.0479225 0.2733345488 1.535890e-01 2.665486e-01 4 121801593 121801826 234 + 0.382 0.000 -12.804
ENSG00000123737 E008 279.8829826 0.0011097252 1.988435e-02 5.124376e-02 4 121801827 121801921 95 + 2.440 2.367 -0.242
ENSG00000123737 E009 206.2189753 0.0002084057 6.735595e-02 1.389611e-01 4 121802674 121802732 59 + 2.303 2.244 -0.195
ENSG00000123737 E010 133.1134668 0.0074179407 5.590561e-01 6.872231e-01 4 121802733 121802737 5 + 2.108 2.062 -0.152
ENSG00000123737 E011 205.9178738 0.0050649621 5.756560e-01 7.012050e-01 4 121802738 121802793 56 + 2.294 2.256 -0.125
ENSG00000123737 E012 250.8505691 0.0003869800 3.965519e-02 9.038889e-02 4 121802915 121803017 103 + 2.387 2.325 -0.207
ENSG00000123737 E013 1.0267042 0.0139290748 7.200867e-02 1.466768e-01 4 121804499 121804621 123 + 0.381 0.000 -12.797
ENSG00000123737 E014 298.8909114 0.0002557575 8.192890e-03 2.427309e-02 4 121804622 121804731 110 + 2.467 2.397 -0.233
ENSG00000123737 E015 152.5661277 0.0002332498 2.704629e-02 6.608957e-02 4 121804732 121804733 2 + 2.178 2.099 -0.265
ENSG00000123737 E016 188.2066743 0.0001902774 3.369284e-02 7.914339e-02 4 121804734 121804759 26 + 2.267 2.198 -0.230
ENSG00000123737 E017 302.6226317 0.0001614647 6.050530e-03 1.874374e-02 4 121807540 121807622 83 + 2.472 2.402 -0.234
ENSG00000123737 E018 2.8225252 0.0055716656 1.368864e-02 3.751144e-02 4 121807623 121807868 246 + 0.664 0.184 -2.778
ENSG00000123737 E019 11.3154103 0.0023092546 3.295523e-02 7.771544e-02 4 121809834 121809916 83 + 1.122 0.865 -0.952
ENSG00000123737 E020 192.5975567 0.0002455753 5.273425e-05 2.954150e-04 4 121809967 121809985 19 + 2.293 2.167 -0.420
ENSG00000123737 E021 330.0029889 0.0035894985 2.402008e-01 3.743630e-01 4 121809986 121810073 88 + 2.504 2.459 -0.152
ENSG00000123737 E022 206.0995539 0.0005717265 9.092949e-02 1.766132e-01 4 121810074 121810099 26 + 2.275 2.316 0.136
ENSG00000123737 E023 329.9268835 0.0001838838 7.281668e-03 2.195591e-02 4 121811583 121811671 89 + 2.474 2.523 0.163
ENSG00000123737 E024 461.7626142 0.0001186815 3.024548e-04 1.389542e-03 4 121813234 121813380 147 + 2.617 2.672 0.184
ENSG00000123737 E025 12.5333854 0.0013662727 2.891612e-03 9.946025e-03 4 121813755 121813865 111 + 1.183 0.833 -1.297
ENSG00000123737 E026 499.9701327 0.0001214164 9.156334e-13 2.262771e-11 4 121813866 121814047 182 + 2.631 2.741 0.367
ENSG00000123737 E027 126.9430405 0.0088249997 2.480534e-07 2.334822e-06 4 121814048 121815349 1302 + 2.152 1.826 -1.096
ENSG00000123737 E028 114.0244311 0.0019818450 4.905930e-05 2.770059e-04 4 121815350 121816143 794 + 2.080 1.895 -0.621
ENSG00000123737 E029 49.9089335 0.0004756743 1.004230e-06 8.327426e-06 4 121816144 121816194 51 + 1.586 1.829 0.823
ENSG00000123737 E030 24.0164008 0.0008097902 1.156934e-01 2.138110e-01 4 121816195 121816368 174 + 1.328 1.437 0.379
ENSG00000123737 E031 215.6823986 0.0002105648 5.896971e-16 2.297272e-14 4 121816369 121816447 79 + 2.233 2.429 0.655
ENSG00000123737 E032 22.0418173 0.0008435538 8.472676e-01 9.051290e-01 4 121816448 121816771 324 + 1.336 1.344 0.028
ENSG00000123737 E033 201.3267735 0.0002141516 1.386101e-09 2.001926e-08 4 121816772 121817021 250 + 2.223 2.375 0.506