ENSG00000123728

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342983 ENSG00000123728 HEK293_OSMI2_2hA HEK293_TMG_2hB RAP2C protein_coding protein_coding 13.30227 9.473382 21.01561 0.9963181 0.4077889 1.148674 6.442500 3.530132 10.365078 0.2284851 0.1979565 1.5512474 0.4658208 0.3799667 0.4933000 0.1133333 1.505854e-01 2.755451e-14 FALSE TRUE
ENST00000460462 ENSG00000123728 HEK293_OSMI2_2hA HEK293_TMG_2hB RAP2C protein_coding processed_transcript 13.30227 9.473382 21.01561 0.9963181 0.4077889 1.148674 2.480896 0.000000 4.361937 0.0000000 0.8020304 8.7721289 0.1252667 0.0000000 0.2073667 0.2073667 2.755451e-14 2.755451e-14 FALSE TRUE
ENST00000620646 ENSG00000123728 HEK293_OSMI2_2hA HEK293_TMG_2hB RAP2C protein_coding protein_coding 13.30227 9.473382 21.01561 0.9963181 0.4077889 1.148674 3.614749 5.422382 4.618893 1.2815612 0.8850996 -0.2309178 0.3552167 0.5575333 0.2196667 -0.3378667 4.965784e-03 2.755451e-14 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123728 E001 0.0000000       X 132203024 132203024 1 -      
ENSG00000123728 E002 75.8543144 0.0104962708 1.860406e-14 5.886894e-13 X 132203025 132203249 225 - 1.594 2.132 1.813
ENSG00000123728 E003 452.3815634 0.0048221905 2.164254e-11 4.267841e-10 X 132203250 132204299 1050 - 2.532 2.785 0.842
ENSG00000123728 E004 54.6483671 0.0005216871 7.633045e-01 8.466577e-01 X 132204300 132204307 8 - 1.712 1.780 0.229
ENSG00000123728 E005 335.3953823 0.0006500879 1.005011e-01 1.912109e-01 X 132204308 132205059 752 - 2.482 2.568 0.289
ENSG00000123728 E006 153.6906345 0.0002469429 4.312814e-01 5.738474e-01 X 132205060 132205448 389 - 2.148 2.224 0.254
ENSG00000123728 E007 127.2265431 0.0022367931 5.426943e-07 4.767401e-06 X 132205449 132205587 139 - 2.146 2.003 -0.476
ENSG00000123728 E008 217.4558630 0.0003313633 4.704973e-18 2.390301e-16 X 132214134 132214446 313 - 2.385 2.218 -0.555
ENSG00000123728 E009 116.0371083 0.0009547404 3.731535e-09 4.973464e-08 X 132216996 132217141 146 - 2.113 1.948 -0.554
ENSG00000123728 E010 53.3757122 0.0004519756 6.429145e-05 3.524152e-04 X 132217142 132217156 15 - 1.773 1.622 -0.513
ENSG00000123728 E011 78.0665264 0.0003888953 4.535182e-06 3.260756e-05 X 132217157 132217277 121 - 1.934 1.793 -0.474
ENSG00000123728 E012 60.0239758 0.0042206491 2.126667e-03 7.617090e-03 X 132217278 132217367 90 - 1.817 1.688 -0.435
ENSG00000123728 E013 47.0706256 0.0079163901 2.378414e-02 5.937244e-02 X 132217368 132217665 298 - 1.704 1.594 -0.372
ENSG00000123728 E014 20.5125636 0.0576194919 4.034574e-01 5.472328e-01 X 132217666 132217756 91 - 1.341 1.267 -0.259
ENSG00000123728 E015 18.7529725 0.0204793183 1.206274e-02 3.368489e-02 X 132217757 132217806 50 - 1.355 1.115 -0.848
ENSG00000123728 E016 15.9055741 0.0236197428 3.350449e-03 1.129277e-02 X 132217916 132218012 97 - 1.308 0.990 -1.141
ENSG00000123728 E017 4.5383442 0.0037472561 1.126311e-03 4.391902e-03 X 132218013 132218231 219 - 0.859 0.376 -2.176
ENSG00000123728 E018 0.6277178 0.0437030159 6.538240e-01 7.641978e-01 X 132218232 132218333 102 - 0.228 0.164 -0.590
ENSG00000123728 E019 0.1515154 0.0437393406 8.735180e-01   X 132218334 132218341 8 - 0.090 0.000 -8.197
ENSG00000123728 E020 0.1515154 0.0437393406 8.735180e-01   X 132218342 132218832 491 - 0.090 0.000 -8.197
ENSG00000123728 E021 3.0100903 0.1351651082 5.265353e-01 6.597563e-01 X 132219370 132219480 111 - 0.626 0.522 -0.469