ENSG00000123684

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366997 ENSG00000123684 HEK293_OSMI2_2hA HEK293_TMG_2hB LPGAT1 protein_coding protein_coding 12.41248 3.273029 22.49446 0.2095246 0.9410416 2.777112 9.863486 3.261876 16.975988 0.1984245 0.8300309 2.376155 0.8668000 0.9969667 0.7542667 -0.2427000 2.756700e-19 2.7567e-19 FALSE TRUE
MSTRG.3006.2 ENSG00000123684 HEK293_OSMI2_2hA HEK293_TMG_2hB LPGAT1 protein_coding   12.41248 3.273029 22.49446 0.2095246 0.9410416 2.777112 1.996480 0.000000 4.841437 0.0000000 0.1840256 8.922268 0.1000875 0.0000000 0.2160333 0.2160333 2.957322e-17 2.7567e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123684 E001 1577.3837296 0.0002565216 2.492058e-92 5.976113e-89 1 211743457 211749676 6220 - 3.049 3.201 0.503
ENSG00000123684 E002 31.9224510 0.0136861891 1.017171e-01 1.931112e-01 1 211749677 211749689 13 - 1.425 1.259 -0.578
ENSG00000123684 E003 54.9281548 0.0004963328 2.455840e-03 8.631433e-03 1 211749690 211749792 103 - 1.658 1.463 -0.668
ENSG00000123684 E004 112.9395398 0.0002672115 1.879302e-06 1.470964e-05 1 211749793 211750050 258 - 1.969 1.750 -0.738
ENSG00000123684 E005 72.0781332 0.0013502477 2.969663e-08 3.345586e-07 1 211750961 211751067 107 - 1.792 1.426 -1.249
ENSG00000123684 E006 67.8701233 0.0008481465 2.814166e-09 3.841032e-08 1 211778918 211778999 82 - 1.769 1.358 -1.405
ENSG00000123684 E007 47.4689028 0.0005386315 2.141520e-06 1.654831e-05 1 211779000 211779044 45 - 1.614 1.239 -1.297
ENSG00000123684 E008 134.3365615 0.0002769952 8.012507e-12 1.693883e-10 1 211783229 211783502 274 - 2.054 1.744 -1.042
ENSG00000123684 E009 80.3167427 0.0003224789 1.541231e-06 1.228594e-05 1 211787632 211787727 96 - 1.830 1.556 -0.927
ENSG00000123684 E010 98.9002686 0.0002784085 2.841835e-07 2.642730e-06 1 211793072 211793190 119 - 1.917 1.657 -0.881
ENSG00000123684 E011 0.6060617 0.8327446218 1.000000e+00 1.000000e+00 1 211793191 211793326 136 - 0.191 0.001 -8.103
ENSG00000123684 E012 78.1683448 0.0003467635 1.055484e-05 6.978439e-05 1 211829059 211829178 120 - 1.815 1.566 -0.847
ENSG00000123684 E013 63.4730808 0.0003740298 1.222848e-09 1.781490e-08 1 211829179 211829319 141 - 1.744 1.311 -1.485
ENSG00000123684 E014 14.9256230 0.0012382456 1.342795e-08 1.616499e-07 1 211829320 211829323 4 - 1.169 0.000 -18.224
ENSG00000123684 E015 0.7425998 0.0631025005 2.081466e-01 3.362446e-01 1 211829450 211830182 733 - 0.149 0.406 1.919
ENSG00000123684 E016 19.2197080 0.0009517862 9.482251e-11 1.679334e-09 1 211830183 211830330 148 - 1.272 0.000 -18.546
ENSG00000123684 E017 25.7813986 0.0007773223 6.410227e-11 1.167017e-09 1 211830573 211830763 191 - 1.388 0.408 -3.911