ENSG00000123643

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000243389 ENSG00000123643 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC36A1 protein_coding protein_coding 9.332723 9.083489 8.044627 0.6751824 0.04928689 -0.1750161 7.5342110 7.039182 6.1700466 1.15277385 0.01854041 -0.1898381 0.80290833 0.76440000 0.76706667 0.002666667 0.97998617 0.01368414 FALSE  
ENST00000429484 ENSG00000123643 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC36A1 protein_coding protein_coding 9.332723 9.083489 8.044627 0.6751824 0.04928689 -0.1750161 0.2523482 0.106426 0.5251303 0.05326946 0.11206132 2.2004773 0.02751250 0.01206667 0.06546667 0.053400000 0.03447195 0.01368414 FALSE  
ENST00000522185 ENSG00000123643 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC36A1 protein_coding nonsense_mediated_decay 9.332723 9.083489 8.044627 0.6751824 0.04928689 -0.1750161 0.5763666 1.281957 0.0000000 0.71167423 0.00000000 -7.0134145 0.06245417 0.15453333 0.00000000 -0.154533333 0.18480475 0.01368414 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123643 E001 0.0000000       5 151437046 151437046 1 +      
ENSG00000123643 E002 0.0000000       5 151437047 151437085 39 +      
ENSG00000123643 E003 0.0000000       5 151437086 151437179 94 +      
ENSG00000123643 E004 0.1451727 0.0430445541 3.889690e-01   5 151447603 151447605 3 + 0.121 0.000 -9.429
ENSG00000123643 E005 2.4054635 0.0076937437 8.281492e-01 8.920106e-01 5 151447606 151447613 8 + 0.513 0.560 0.220
ENSG00000123643 E006 8.9470951 0.0266723093 1.679897e-01 2.855861e-01 5 151447614 151447626 13 + 1.028 0.952 -0.279
ENSG00000123643 E007 13.6584656 0.0063744178 3.489661e-01 4.931822e-01 5 151447627 151447641 15 + 1.153 1.171 0.065
ENSG00000123643 E008 26.7793622 0.0026634484 8.828793e-01 9.290625e-01 5 151447642 151447706 65 + 1.384 1.486 0.351
ENSG00000123643 E009 30.7034075 0.0006766506 9.830615e-01 9.934710e-01 5 151447707 151447768 62 + 1.433 1.546 0.389
ENSG00000123643 E010 30.7194441 0.0086917652 2.875492e-01 4.280498e-01 5 151447769 151447800 32 + 1.477 1.511 0.116
ENSG00000123643 E011 26.5583825 0.0134792703 4.602727e-01 6.003172e-01 5 151447801 151447813 13 + 1.406 1.455 0.170
ENSG00000123643 E012 1.8757761 0.0077242983 6.174575e-01 7.352601e-01 5 151447814 151447879 66 + 0.360 0.519 0.837
ENSG00000123643 E013 0.6600969 0.0411302892 8.062017e-01 8.768035e-01 5 151450923 151451041 119 + 0.216 0.220 0.030
ENSG00000123643 E014 3.1658695 0.0061466742 2.290206e-01 3.612656e-01 5 151452343 151452491 149 + 0.657 0.560 -0.429
ENSG00000123643 E015 59.1396823 0.0039655268 1.643083e-02 4.368127e-02 5 151458788 151458935 148 + 1.783 1.771 -0.040
ENSG00000123643 E016 0.0000000       5 151459774 151459864 91 +      
ENSG00000123643 E017 41.9867075 0.0126673415 1.967695e-03 7.125020e-03 5 151463553 151463643 91 + 1.691 1.572 -0.405
ENSG00000123643 E018 29.4198586 0.0130588547 5.323484e-02 1.149033e-01 5 151464514 151464602 89 + 1.504 1.462 -0.145
ENSG00000123643 E019 38.1746461 0.0005976557 1.057562e-04 5.484887e-04 5 151465074 151465169 96 + 1.642 1.538 -0.354
ENSG00000123643 E020 41.0683156 0.0052882965 3.520384e-04 1.588340e-03 5 151467199 151467283 85 + 1.673 1.561 -0.382
ENSG00000123643 E021 79.1719272 0.0003373372 6.028600e-07 5.248622e-06 5 151467707 151467925 219 + 1.940 1.859 -0.270
ENSG00000123643 E022 2.6174350 0.0055393350 2.822027e-02 6.845121e-02 5 151469246 151469271 26 + 0.687 0.422 -1.235
ENSG00000123643 E023 2.9484542 0.0444593012 7.049389e-04 2.916544e-03 5 151470831 151470959 129 + 0.811 0.296 -2.484
ENSG00000123643 E024 50.3696582 0.0005515904 6.984933e-07 5.999612e-06 5 151473673 151473771 99 + 1.768 1.638 -0.443
ENSG00000123643 E025 0.4772466 0.0205946880 7.184999e-01 8.135753e-01 5 151476589 151476589 1 + 0.121 0.219 1.027
ENSG00000123643 E026 62.4260712 0.0032173138 6.074150e-04 2.560249e-03 5 151476590 151476756 167 + 1.824 1.765 -0.200
ENSG00000123643 E027 0.0000000       5 151476855 151476980 126 +      
ENSG00000123643 E028 54.2867452 0.0092298161 1.377163e-03 5.232220e-03 5 151479320 151479489 170 + 1.783 1.692 -0.307
ENSG00000123643 E029 1.3651209 0.0096495142 4.038670e-02 9.172712e-02 5 151479490 151479759 270 + 0.513 0.219 -1.779
ENSG00000123643 E030 1.0287911 0.0120787237 7.657221e-01 8.484104e-01 5 151480057 151480144 88 + 0.294 0.298 0.030
ENSG00000123643 E031 0.2955422 0.0297727100 8.573212e-01   5 151481133 151481165 33 + 0.121 0.123 0.026
ENSG00000123643 E032 932.0109903 0.0076649333 1.171211e-09 1.713643e-08 5 151487983 151492379 4397 + 2.824 3.061 0.788
ENSG00000123643 E033 0.6600969 0.0411302892 8.062017e-01 8.768035e-01 5 151539253 151539301 49 + 0.216 0.220 0.030