ENSG00000123562

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360458 ENSG00000123562 HEK293_OSMI2_2hA HEK293_TMG_2hB MORF4L2 protein_coding protein_coding 267.8796 230.8785 397.6845 38.58234 12.66629 0.7844643 30.46745 26.743299 56.44436 7.509572 5.631681 1.0773682 0.10713750 0.11186667 0.14133333 0.02946667 4.021390e-01 2.681483e-06 FALSE TRUE
ENST00000441076 ENSG00000123562 HEK293_OSMI2_2hA HEK293_TMG_2hB MORF4L2 protein_coding protein_coding 267.8796 230.8785 397.6845 38.58234 12.66629 0.7844643 127.99333 122.324680 162.58588 21.194076 1.141829 0.4104572 0.49338333 0.52890000 0.40966667 -0.11923333 2.681483e-06 2.681483e-06 FALSE TRUE
ENST00000442614 ENSG00000123562 HEK293_OSMI2_2hA HEK293_TMG_2hB MORF4L2 protein_coding protein_coding 267.8796 230.8785 397.6845 38.58234 12.66629 0.7844643 18.65149 9.726638 35.54368 1.319307 2.267822 1.8685034 0.06315417 0.04313333 0.08926667 0.04613333 4.116081e-04 2.681483e-06 FALSE FALSE
ENST00000451301 ENSG00000123562 HEK293_OSMI2_2hA HEK293_TMG_2hB MORF4L2 protein_coding protein_coding 267.8796 230.8785 397.6845 38.58234 12.66629 0.7844643 16.37366 22.374901 19.77213 4.609081 3.148955 -0.1783282 0.06450000 0.09580000 0.04940000 -0.04640000 9.823278e-04 2.681483e-06 FALSE TRUE
ENST00000498064 ENSG00000123562 HEK293_OSMI2_2hA HEK293_TMG_2hB MORF4L2 protein_coding processed_transcript 267.8796 230.8785 397.6845 38.58234 12.66629 0.7844643 42.56852 30.053919 68.43765 3.556747 3.616675 1.1869678 0.15267917 0.13223333 0.17200000 0.03976667 4.824435e-02 2.681483e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123562 E001 1.265000 1.147538e-02 8.143132e-01 8.823450e-01 X 103675496 103675497 2 - 0.362 0.347 -0.091
ENSG00000123562 E002 12.628108 3.443313e-03 9.522272e-07 7.933705e-06 X 103675498 103675499 2 - 0.844 1.368 1.899
ENSG00000123562 E003 6504.920986 3.888044e-03 4.969385e-08 5.360942e-07 X 103675500 103676494 995 - 3.731 3.895 0.546
ENSG00000123562 E004 854.140990 1.730406e-04 2.091714e-01 3.375317e-01 X 103676495 103676496 2 - 2.908 2.971 0.210
ENSG00000123562 E005 1284.280018 9.215767e-05 8.946657e-01 9.366979e-01 X 103676497 103676553 57 - 3.093 3.137 0.146
ENSG00000123562 E006 1132.331522 3.673752e-04 1.184797e-01 2.177599e-01 X 103676554 103676605 52 - 3.047 3.067 0.068
ENSG00000123562 E007 1620.968527 7.039723e-04 8.225160e-06 5.572079e-05 X 103676606 103676693 88 - 3.223 3.193 -0.099
ENSG00000123562 E008 1831.160430 1.438439e-03 7.751222e-03 2.315467e-02 X 103676694 103676825 132 - 3.269 3.251 -0.061
ENSG00000123562 E009 1371.538554 4.350741e-04 4.535722e-05 2.582433e-04 X 103676826 103676915 90 - 3.145 3.129 -0.055
ENSG00000123562 E010 1408.984787 1.869990e-03 8.748996e-02 1.713290e-01 X 103676916 103676978 63 - 3.151 3.142 -0.027
ENSG00000123562 E011 1715.552232 1.809848e-03 8.038742e-03 2.387651e-02 X 103676979 103677051 73 - 3.244 3.216 -0.093
ENSG00000123562 E012 1731.173694 1.296836e-03 7.165333e-06 4.921665e-05 X 103678499 103678600 102 - 3.259 3.206 -0.175
ENSG00000123562 E013 461.091243 1.368587e-03 1.727210e-01 2.917419e-01 X 103678601 103678620 20 - 2.663 2.666 0.009
ENSG00000123562 E014 418.516453 1.667083e-03 7.841175e-01 8.615165e-01 X 103678621 103678651 31 - 2.610 2.638 0.094
ENSG00000123562 E015 311.407071 2.924051e-04 5.006217e-12 1.094912e-10 X 103684681 103684729 49 - 2.540 2.434 -0.352
ENSG00000123562 E016 14.370785 1.170361e-02 1.459443e-07 1.436297e-06 X 103684974 103685170 197 - 1.349 0.771 -2.123
ENSG00000123562 E017 1491.996032 1.016926e-03 9.531196e-06 6.366239e-05 X 103685171 103685260 90 - 3.192 3.147 -0.148
ENSG00000123562 E018 50.204617 1.590628e-02 5.173057e-01 6.517174e-01 X 103685261 103685505 245 - 1.716 1.689 -0.092
ENSG00000123562 E019 944.535613 1.400932e-04 3.864936e-02 8.853373e-02 X 103686631 103686747 117 - 2.970 2.989 0.062
ENSG00000123562 E020 7.469877 3.029727e-03 4.689504e-01 6.082878e-01 X 103686748 103686818 71 - 0.945 0.899 -0.172
ENSG00000123562 E021 89.531345 3.350939e-04 1.217825e-33 2.695249e-31 X 103687989 103688158 170 - 2.102 1.633 -1.583