ENSG00000123473

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337817 ENSG00000123473 HEK293_OSMI2_2hA HEK293_TMG_2hB STIL protein_coding protein_coding 12.05675 6.764758 16.45691 0.2120065 0.1989694 1.281328 0.7713477 0.1947138 1.1992847 0.1298118 0.29950477 2.5624738 0.06371250 0.02973333 0.0725000 0.0427666667 0.370298783 0.0006322597 FALSE TRUE
ENST00000371877 ENSG00000123473 HEK293_OSMI2_2hA HEK293_TMG_2hB STIL protein_coding protein_coding 12.05675 6.764758 16.45691 0.2120065 0.1989694 1.281328 3.2143228 1.6536141 4.9240237 0.3273932 0.21511014 1.5684438 0.26237083 0.24236667 0.2995333 0.0571666667 0.594991482 0.0006322597 FALSE TRUE
ENST00000396221 ENSG00000123473 HEK293_OSMI2_2hA HEK293_TMG_2hB STIL protein_coding protein_coding 12.05675 6.764758 16.45691 0.2120065 0.1989694 1.281328 2.4368644 0.5739749 3.9563459 0.1411807 0.25634143 2.7638323 0.17139167 0.08463333 0.2407667 0.1561333333 0.001122785 0.0006322597 FALSE TRUE
ENST00000682940 ENSG00000123473 HEK293_OSMI2_2hA HEK293_TMG_2hB STIL protein_coding retained_intron 12.05675 6.764758 16.45691 0.2120065 0.1989694 1.281328 0.5824315 1.3033798 0.1884974 0.6325927 0.10641177 -2.7260918 0.07842917 0.19476667 0.0116000 -0.1831666667 0.028790141 0.0006322597 FALSE TRUE
ENST00000683977 ENSG00000123473 HEK293_OSMI2_2hA HEK293_TMG_2hB STIL protein_coding protein_coding 12.05675 6.764758 16.45691 0.2120065 0.1989694 1.281328 2.4510327 2.1058062 2.6577580 0.3424498 0.51126918 0.3344203 0.22236250 0.31253333 0.1611333 -0.1514000000 0.124740554 0.0006322597 FALSE TRUE
ENST00000684618 ENSG00000123473 HEK293_OSMI2_2hA HEK293_TMG_2hB STIL protein_coding processed_transcript 12.05675 6.764758 16.45691 0.2120065 0.1989694 1.281328 1.4085136 0.7052338 1.7113969 0.1982957 0.04887264 1.2670928 0.11957500 0.10336667 0.1041000 0.0007333333 0.958766450 0.0006322597 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123473 E001 2.5828884 0.0057028704 3.422443e-02 8.019042e-02 1 47250139 47250172 34 - 0.390 0.746 1.650
ENSG00000123473 E002 23.5181270 0.0696548335 2.033957e-02 5.219607e-02 1 47250173 47250242 70 - 1.199 1.590 1.354
ENSG00000123473 E003 126.1422317 0.0158744891 3.908698e-09 5.193513e-08 1 47250243 47250621 379 - 1.889 2.316 1.431
ENSG00000123473 E004 52.6761329 0.0092576736 1.109555e-07 1.117857e-06 1 47250622 47250658 37 - 1.540 1.918 1.279
ENSG00000123473 E005 105.8110092 0.0054570867 6.697355e-12 1.435287e-10 1 47250659 47250828 170 - 1.850 2.208 1.202
ENSG00000123473 E006 157.0461386 0.0026498292 6.118885e-16 2.376880e-14 1 47250829 47251135 307 - 2.042 2.361 1.067
ENSG00000123473 E007 190.8984209 0.0002674984 6.402732e-14 1.870148e-12 1 47251136 47251532 397 - 2.170 2.391 0.738
ENSG00000123473 E008 77.7784855 0.0029455544 1.133058e-01 2.103445e-01 1 47251533 47251612 80 - 1.833 1.934 0.342
ENSG00000123473 E009 47.1723902 0.0041260452 4.387182e-01 5.805743e-01 1 47251613 47251620 8 - 1.630 1.702 0.245
ENSG00000123473 E010 70.3313026 0.0008609492 2.336259e-02 5.850436e-02 1 47251621 47251681 61 - 1.781 1.908 0.428
ENSG00000123473 E011 105.2766610 0.0003277013 2.769979e-04 1.286029e-03 1 47251682 47251922 241 - 1.943 2.097 0.519
ENSG00000123473 E012 63.7802879 0.0022146817 1.785137e-01 2.992874e-01 1 47260289 47260429 141 - 1.753 1.846 0.315
ENSG00000123473 E013 61.1442937 0.0004401230 4.398786e-01 5.816142e-01 1 47260430 47260539 110 - 1.748 1.810 0.210
ENSG00000123473 E014 94.5071427 0.0074786717 2.359867e-01 3.695254e-01 1 47262903 47263062 160 - 1.967 1.925 -0.142
ENSG00000123473 E015 39.7194434 0.0250043678 3.022331e-01 4.440856e-01 1 47263063 47263113 51 - 1.609 1.532 -0.265
ENSG00000123473 E016 9.9841756 0.0017129066 2.279115e-01 3.599416e-01 1 47263114 47263116 3 - 1.049 0.936 -0.419
ENSG00000123473 E017 101.6511269 0.0046040388 1.081677e-02 3.072546e-02 1 47269635 47269866 232 - 2.016 1.914 -0.343
ENSG00000123473 E018 88.2454279 0.0003484910 2.225547e-04 1.060127e-03 1 47272076 47272241 166 - 1.962 1.833 -0.432
ENSG00000123473 E019 82.1645690 0.0026434726 1.410654e-03 5.341891e-03 1 47280241 47280363 123 - 1.932 1.800 -0.445
ENSG00000123473 E020 176.9109742 0.0002153274 5.111082e-06 3.630049e-05 1 47280364 47280945 582 - 2.255 2.149 -0.356
ENSG00000123473 E021 101.2673267 0.0009510002 3.167440e-05 1.873734e-04 1 47280946 47281209 264 - 2.023 1.877 -0.491
ENSG00000123473 E022 0.5943067 0.0202313213 8.269694e-01 8.911652e-01 1 47281616 47281638 23 - 0.211 0.178 -0.298
ENSG00000123473 E023 59.9055001 0.0006119369 4.498656e-04 1.966127e-03 1 47282345 47282459 115 - 1.801 1.646 -0.525
ENSG00000123473 E024 2.4119992 0.0067152383 1.794674e-02 4.702079e-02 1 47282460 47282847 388 - 0.615 0.179 -2.618
ENSG00000123473 E025 2.7346099 0.0053329841 5.482725e-02 1.177021e-01 1 47282848 47283541 694 - 0.637 0.305 -1.711
ENSG00000123473 E026 0.4502799 0.0287317776 3.105566e-01 4.529665e-01 1 47283542 47284073 532 - 0.211 0.000 -10.233
ENSG00000123473 E027 59.7837368 0.0100734798 2.589202e-03 9.032787e-03 1 47287551 47287660 110 - 1.809 1.623 -0.632
ENSG00000123473 E028 69.1614895 0.0143089733 2.557221e-03 8.933827e-03 1 47289435 47289585 151 - 1.874 1.675 -0.674
ENSG00000123473 E029 61.1730035 0.0004200217 1.256842e-08 1.521631e-07 1 47293458 47293544 87 - 1.838 1.564 -0.930
ENSG00000123473 E030 57.6829620 0.0004263164 2.878260e-08 3.251701e-07 1 47295765 47295848 84 - 1.814 1.539 -0.934
ENSG00000123473 E031 0.6653823 0.0170278525 8.290785e-01 8.926493e-01 1 47299777 47299904 128 - 0.211 0.179 -0.295
ENSG00000123473 E032 45.9866887 0.0118122863 5.600140e-02 1.196974e-01 1 47299905 47299968 64 - 1.680 1.560 -0.407
ENSG00000123473 E033 46.5667359 0.0004957033 2.315963e-02 5.808058e-02 1 47299969 47300109 141 - 1.684 1.581 -0.348
ENSG00000123473 E034 35.9149293 0.0011502633 4.466086e-03 1.444573e-02 1 47300110 47300152 43 - 1.592 1.430 -0.555
ENSG00000123473 E035 70.8091491 0.0028639858 1.052361e-08 1.291653e-07 1 47301561 47301748 188 - 1.906 1.615 -0.985
ENSG00000123473 E036 57.1291661 0.0017442911 1.454844e-11 2.949655e-10 1 47302234 47302346 113 - 1.832 1.454 -1.283
ENSG00000123473 E037 51.9696264 0.0030649738 9.816684e-07 8.156760e-06 1 47304889 47304996 108 - 1.773 1.492 -0.958
ENSG00000123473 E038 0.4545463 0.6777665416 6.086855e-01 7.283442e-01 1 47304997 47305317 321 - 0.212 0.000 -10.246
ENSG00000123473 E039 43.4653805 0.0007891706 1.657795e-05 1.047440e-04 1 47310276 47310362 87 - 1.687 1.447 -0.822
ENSG00000123473 E040 6.8726534 0.0461183298 6.288605e-01 7.443305e-01 1 47312948 47313021 74 - 0.884 0.825 -0.228
ENSG00000123473 E041 6.9142602 0.0292858448 4.978470e-02 1.087814e-01 1 47313022 47313156 135 - 0.950 0.660 -1.145
ENSG00000123473 E042 6.1329637 0.1095943963 1.109008e-01 2.068731e-01 1 47313157 47313314 158 - 0.906 0.612 -1.192
ENSG00000123473 E043 36.4880427 0.0039128233 3.591763e-04 1.615730e-03 1 47314036 47314563 528 - 1.612 1.378 -0.803
ENSG00000123473 E044 2.4368619 0.0071995178 7.635326e-01 8.468314e-01 1 47314802 47314892 91 - 0.517 0.482 -0.169