ENSG00000123360

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000243052 ENSG00000123360 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE1B protein_coding protein_coding 0.6528079 1.175457 0.3994831 0.05542948 0.03598683 -1.533567 0.49581982 1.14606944 0.29531229 0.04061686 0.007386257 -1.9208705 0.66844167 0.9761333 0.75626667 -0.21986667 0.01107275 0.01107275 FALSE TRUE
ENST00000394277 ENSG00000123360 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE1B protein_coding processed_transcript 0.6528079 1.175457 0.3994831 0.05542948 0.03598683 -1.533567 0.04568092 0.00000000 0.00000000 0.00000000 0.000000000 0.0000000 0.06636250 0.0000000 0.00000000 0.00000000   0.01107275 FALSE TRUE
ENST00000550285 ENSG00000123360 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE1B protein_coding nonsense_mediated_decay 0.6528079 1.175457 0.3994831 0.05542948 0.03598683 -1.533567 0.03722363 0.00000000 0.00000000 0.00000000 0.000000000 0.0000000 0.09021667 0.0000000 0.00000000 0.00000000   0.01107275 FALSE TRUE
ENST00000552774 ENSG00000123360 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE1B protein_coding retained_intron 0.6528079 1.175457 0.3994831 0.05542948 0.03598683 -1.533567 0.03128471 0.02197478 0.03188021 0.02197478 0.031880211 0.3893343 0.06785417 0.0173000 0.07426667 0.05696667 0.77058258 0.01107275 FALSE TRUE
ENST00000611899 ENSG00000123360 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE1B protein_coding nonsense_mediated_decay 0.6528079 1.175457 0.3994831 0.05542948 0.03598683 -1.533567 0.01365281 0.00000000 0.05212613 0.00000000 0.052126133 2.6352003 0.03017500 0.0000000 0.11813333 0.11813333 0.58615944 0.01107275 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123360 E001 0.7761102 0.1096810937 0.876429753 0.924693206 12 54549601 54549603 3 + 0.214 0.178 -0.333
ENSG00000123360 E002 1.3265088 0.1421363397 0.700443003 0.799914187 12 54549604 54549623 20 + 0.357 0.268 -0.578
ENSG00000123360 E003 1.7672237 0.0101650352 0.187644836 0.310770714 12 54549624 54549667 44 + 0.550 0.301 -1.352
ENSG00000123360 E004 3.3956044 0.1168157325 0.227064582 0.358891239 12 54549668 54549772 105 + 0.737 0.485 -1.120
ENSG00000123360 E005 5.3840724 0.1481064593 0.290165050 0.430958397 12 54549860 54549985 126 + 0.904 0.643 -1.044
ENSG00000123360 E006 0.0000000       12 54550080 54550205 126 +      
ENSG00000123360 E007 0.1472490 0.0431662917 0.120463391   12 54554217 54554377 161 + 0.214 0.000 -11.593
ENSG00000123360 E008 0.0000000       12 54561444 54561456 13 +      
ENSG00000123360 E009 0.0000000       12 54561457 54561500 44 +      
ENSG00000123360 E010 0.0000000       12 54561501 54561637 137 +      
ENSG00000123360 E011 6.3386767 0.0223374230 0.641645736 0.754630162 12 54566974 54567087 114 + 0.828 0.741 -0.347
ENSG00000123360 E012 0.0000000       12 54569122 54569183 62 +      
ENSG00000123360 E013 4.3707597 0.0064667289 0.863496896 0.915950326 12 54569184 54569280 97 + 0.622 0.636 0.061
ENSG00000123360 E014 4.3748241 0.0040143686 0.189776880 0.313479589 12 54569281 54569366 86 + 0.464 0.683 0.997
ENSG00000123360 E015 4.3351704 0.0040163059 0.220644488 0.351192391 12 54569546 54569612 67 + 0.464 0.668 0.934
ENSG00000123360 E016 6.4281635 0.0155106035 0.234936111 0.368281643 12 54570241 54570357 117 + 0.622 0.800 0.737
ENSG00000123360 E017 0.4449813 0.0234184592 0.092714548 0.179367435 12 54570358 54572600 2243 + 0.357 0.067 -2.942
ENSG00000123360 E018 9.2156721 0.0124998702 0.885370732 0.930679760 12 54572601 54572741 141 + 0.937 0.902 -0.133
ENSG00000123360 E019 7.6000248 0.0028264053 0.878102082 0.925720388 12 54573148 54573248 101 + 0.828 0.833 0.020
ENSG00000123360 E020 8.1557209 0.0028841864 0.699937257 0.799533389 12 54573355 54573480 126 + 0.828 0.864 0.138
ENSG00000123360 E021 7.4738686 0.0025730000 0.821144749 0.887250527 12 54573608 54573709 102 + 0.868 0.823 -0.175
ENSG00000123360 E022 0.9567719 0.0164205699 0.018431343 0.048080443 12 54573710 54574756 1047 + 0.550 0.125 -2.939
ENSG00000123360 E023 0.1451727 0.0430728149 0.120699036   12 54574757 54575097 341 + 0.214 0.000 -11.593
ENSG00000123360 E024 7.2919633 0.0032202444 0.815574012 0.883246346 12 54575098 54575218 121 + 0.868 0.822 -0.177
ENSG00000123360 E025 5.5990256 0.0034630399 0.469358675 0.608597936 12 54575551 54575632 82 + 0.828 0.712 -0.468
ENSG00000123360 E026 5.7725894 0.1102180431 0.525174578 0.658587067 12 54575992 54576100 109 + 0.829 0.724 -0.419
ENSG00000123360 E027 7.2378395 0.0233111397 0.773250786 0.853681521 12 54576571 54576701 131 + 0.868 0.818 -0.192
ENSG00000123360 E028 4.9044995 0.0052691391 0.480402340 0.618704288 12 54577225 54577345 121 + 0.785 0.667 -0.484
ENSG00000123360 E029 31.0563027 0.0008021709 0.002418234 0.008516482 12 54577860 54579239 1380 + 1.212 1.427 0.751