ENSG00000123358

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000243050 ENSG00000123358 HEK293_OSMI2_2hA HEK293_TMG_2hB NR4A1 protein_coding protein_coding 5.725715 8.571663 4.674476 0.7644133 0.1871907 -0.8733695 0.1426112 0.05028522 0.4720059 0.05028522 0.11212512 2.9991744 0.02760417 0.005633333 0.10296667 0.09733333 0.007777668 2.474065e-05 FALSE  
ENST00000394825 ENSG00000123358 HEK293_OSMI2_2hA HEK293_TMG_2hB NR4A1 protein_coding protein_coding 5.725715 8.571663 4.674476 0.7644133 0.1871907 -0.8733695 2.4478295 4.22370437 2.0879313 0.81034385 0.35662261 -1.0129531 0.42976667 0.483166667 0.44210000 -0.04106667 0.869787643 2.474065e-05 FALSE  
ENST00000550082 ENSG00000123358 HEK293_OSMI2_2hA HEK293_TMG_2hB NR4A1 protein_coding protein_coding 5.725715 8.571663 4.674476 0.7644133 0.1871907 -0.8733695 0.3793426 0.51404254 0.0000000 0.51404254 0.00000000 -5.7116120 0.06539583 0.072366667 0.00000000 -0.07236667 0.883488472 2.474065e-05 FALSE  
MSTRG.7323.5 ENSG00000123358 HEK293_OSMI2_2hA HEK293_TMG_2hB NR4A1 protein_coding   5.725715 8.571663 4.674476 0.7644133 0.1871907 -0.8733695 1.4125665 2.24165361 1.2490208 0.64337579 0.06770187 -0.8386827 0.22773333 0.252333333 0.26740000 0.01506667 0.918346359 2.474065e-05 FALSE  
MSTRG.7323.6 ENSG00000123358 HEK293_OSMI2_2hA HEK293_TMG_2hB NR4A1 protein_coding   5.725715 8.571663 4.674476 0.7644133 0.1871907 -0.8733695 0.4564010 0.34968279 0.1914144 0.34968279 0.10728756 -0.8365580 0.08212500 0.049233333 0.04263333 -0.00660000 0.691222087 2.474065e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123358 E001 0.0000000       12 52022832 52022939 108 +      
ENSG00000123358 E002 0.0000000       12 52037177 52037241 65 +      
ENSG00000123358 E003 0.0000000       12 52037242 52037243 2 +      
ENSG00000123358 E004 1.8393461 0.0078350239 0.041944243 0.09462591 12 52037244 52037285 42 + 0.627 0.283 -1.819
ENSG00000123358 E005 11.9685029 0.0020906849 0.057550415 0.12241757 12 52037286 52037443 158 + 1.186 0.998 -0.681
ENSG00000123358 E006 2.9723215 0.0056519196 0.328541197 0.47203877 12 52037715 52038749 1035 + 0.672 0.517 -0.692
ENSG00000123358 E007 0.0000000       12 52041805 52041809 5 +      
ENSG00000123358 E008 16.9666131 0.0011538916 0.643488379 0.75602143 12 52041810 52041929 120 + 1.186 1.225 0.140
ENSG00000123358 E009 2.7927926 0.0056420569 0.721558581 0.81587321 12 52043425 52043726 302 + 0.577 0.518 -0.275
ENSG00000123358 E010 2.2360618 0.0082360534 0.042653867 0.09591159 12 52043727 52043801 75 + 0.165 0.547 2.448
ENSG00000123358 E011 4.3186875 0.0294739561 0.551215635 0.68071920 12 52043802 52043838 37 + 0.627 0.726 0.418
ENSG00000123358 E012 6.0221221 0.1009866509 0.730807430 0.82262895 12 52043839 52043911 73 + 0.750 0.845 0.375
ENSG00000123358 E013 3.3515074 0.0057911045 0.089720037 0.17470117 12 52045480 52045568 89 + 0.378 0.669 1.402
ENSG00000123358 E014 0.7708142 0.0153338512 0.033616785 0.07899788 12 52051402 52051441 40 + 0.455 0.090 -3.014
ENSG00000123358 E015 0.9180632 0.0132519101 0.012264042 0.03416600 12 52051442 52051447 6 + 0.520 0.090 -3.336
ENSG00000123358 E016 2.6863468 0.2449533780 0.024697834 0.06125960 12 52051448 52051458 11 + 0.816 0.334 -2.264
ENSG00000123358 E017 4.0922632 0.0408944271 0.039684721 0.09044066 12 52051459 52051462 4 + 0.874 0.548 -1.357
ENSG00000123358 E018 8.4756873 0.0100322519 0.009414517 0.02731864 12 52051463 52051568 106 + 1.130 0.828 -1.125
ENSG00000123358 E019 0.2934659 0.0295089198 0.609468973   12 52051569 52051572 4 + 0.165 0.089 -1.016
ENSG00000123358 E020 0.0000000       12 52052474 52052495 22 +      
ENSG00000123358 E021 0.6319842 0.0313844295 0.093185982 0.18010411 12 52052496 52052499 4 + 0.378 0.090 -2.599
ENSG00000123358 E022 2.1517410 0.0453382231 0.007493686 0.02249602 12 52052500 52052645 146 + 0.750 0.282 -2.343
ENSG00000123358 E023 2.7605273 0.0057460556 0.386591305 0.53076038 12 52053418 52054326 909 + 0.627 0.486 -0.650
ENSG00000123358 E024 69.4299707 0.0006161532 0.086213919 0.16934130 12 52054327 52054651 325 + 1.853 1.778 -0.255
ENSG00000123358 E025 55.3801526 0.0006904027 0.453655936 0.59440038 12 52054652 52054837 186 + 1.674 1.711 0.126
ENSG00000123358 E026 97.0966073 0.0004644366 0.375249534 0.51966111 12 52054838 52055204 367 + 1.921 1.953 0.108
ENSG00000123358 E027 6.5291225 0.0027099006 0.008889208 0.02600383 12 52055205 52055720 516 + 1.030 0.710 -1.235
ENSG00000123358 E028 2.8420112 0.0054549742 0.496158670 0.63288842 12 52055721 52056021 301 + 0.627 0.517 -0.499
ENSG00000123358 E029 0.9276256 0.2100744775 0.794628384 0.86880065 12 52056022 52056029 8 + 0.285 0.232 -0.393
ENSG00000123358 E030 47.5978315 0.0004599587 0.494522366 0.63147174 12 52056030 52056144 115 + 1.615 1.651 0.121
ENSG00000123358 E031 22.9788030 0.0008967207 0.560874338 0.68878588 12 52056145 52056159 15 + 1.300 1.344 0.153
ENSG00000123358 E032 0.1515154 0.0437640548 0.244279522   12 52056160 52056161 2 + 0.165 0.000 -11.675
ENSG00000123358 E033 0.6235652 0.0207891268 0.091662835 0.17772779 12 52056162 52056262 101 + 0.378 0.090 -2.598
ENSG00000123358 E034 1.3524459 0.0117308617 0.801460357 0.87350428 12 52056263 52056493 231 + 0.378 0.332 -0.276
ENSG00000123358 E035 55.4626117 0.0004389300 0.922409190 0.95504612 12 52056494 52056603 110 + 1.711 1.705 -0.020
ENSG00000123358 E036 37.8844688 0.0006363068 0.370756884 0.51517267 12 52056604 52056645 42 + 1.585 1.531 -0.184
ENSG00000123358 E037 0.1817044 0.0395255870 1.000000000   12 52056646 52056688 43 + 0.000 0.090 9.395
ENSG00000123358 E038 0.1482932 0.0420856092 1.000000000   12 52056689 52056889 201 + 0.000 0.089 9.381
ENSG00000123358 E039 0.3634088 0.3635208790 0.571730843   12 52056890 52057056 167 + 0.000 0.165 9.753
ENSG00000123358 E040 82.3576034 0.0004040034 0.549600920 0.67931237 12 52057057 52057259 203 + 1.859 1.882 0.078
ENSG00000123358 E041 71.3855915 0.0004112610 0.196963739 0.32242560 12 52057352 52057530 179 + 1.776 1.832 0.187
ENSG00000123358 E042 148.6384283 0.0010148729 0.028861992 0.06972479 12 52058688 52059507 820 + 2.082 2.150 0.228