ENSG00000123243

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397145 ENSG00000123243 HEK293_OSMI2_2hA HEK293_TMG_2hB ITIH5 protein_coding protein_coding 0.4498093 0.5360531 0.4084009 0.02291774 0.04088863 -0.3841554 0.105340809 0.03908450 0.15284191 0.01957087 0.02525793 1.73013245 0.23801667 0.0760000 0.37146667 0.29546667 0.04212695 0.01403526 FALSE TRUE
ENST00000397146 ENSG00000123243 HEK293_OSMI2_2hA HEK293_TMG_2hB ITIH5 protein_coding protein_coding 0.4498093 0.5360531 0.4084009 0.02291774 0.04088863 -0.3841554 0.089619890 0.09802047 0.10298916 0.02175697 0.02514689 0.06487963 0.21120833 0.1801667 0.25963333 0.07946667 0.73215206 0.01403526 FALSE TRUE
ENST00000468389 ENSG00000123243 HEK293_OSMI2_2hA HEK293_TMG_2hB ITIH5 protein_coding retained_intron 0.4498093 0.5360531 0.4084009 0.02291774 0.04088863 -0.3841554 0.022807061 0.00000000 0.02470114 0.00000000 0.02470114 1.79498290 0.04518750 0.0000000 0.05166667 0.05166667 0.71563239 0.01403526 FALSE TRUE
ENST00000473591 ENSG00000123243 HEK293_OSMI2_2hA HEK293_TMG_2hB ITIH5 protein_coding processed_transcript 0.4498093 0.5360531 0.4084009 0.02291774 0.04088863 -0.3841554 0.004625461 0.00000000 0.03700369 0.00000000 0.03700369 2.23277390 0.01126667 0.0000000 0.09013333 0.09013333 0.73606759 0.01403526   FALSE
ENST00000613909 ENSG00000123243 HEK293_OSMI2_2hA HEK293_TMG_2hB ITIH5 protein_coding protein_coding 0.4498093 0.5360531 0.4084009 0.02291774 0.04088863 -0.3841554 0.202988547 0.38778339 0.08207223 0.02441716 0.04111535 -2.11114501 0.43515833 0.7225000 0.20646667 -0.51603333 0.01403526 0.01403526 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123243 E001 6.3588694 0.003633921 0.383808386 0.528018730 10 7559270 7562423 3154 - 0.924 0.807 -0.453
ENSG00000123243 E002 13.7684771 0.003038917 0.001121752 0.004376377 10 7562424 7563384 961 - 0.945 1.229 1.031
ENSG00000123243 E003 2.4678029 0.059967850 0.142452867 0.251374066 10 7566030 7566036 7 - 0.349 0.608 1.310
ENSG00000123243 E004 4.8292461 0.041500635 0.556856609 0.685419445 10 7566037 7566407 371 - 0.708 0.784 0.306
ENSG00000123243 E005 0.0000000       10 7569162 7569667 506 -      
ENSG00000123243 E006 3.0581458 0.005588349 0.672896144 0.778729679 10 7569668 7569784 117 - 0.632 0.554 -0.351
ENSG00000123243 E007 0.1515154 0.044649934 0.327163095   10 7570107 7570400 294 - 0.150 0.000 -11.719
ENSG00000123243 E008 0.1817044 0.045666407 0.703378037   10 7571405 7572398 994 - 0.000 0.100 9.716
ENSG00000123243 E009 0.1817044 0.045666407 0.703378037   10 7572772 7573141 370 - 0.000 0.100 9.716
ENSG00000123243 E010 2.6645587 0.009208732 0.621053708 0.738072212 10 7573142 7573195 54 - 0.485 0.554 0.328
ENSG00000123243 E011 3.3977945 0.016346103 0.816222217 0.883715955 10 7576453 7576597 145 - 0.589 0.614 0.111
ENSG00000123243 E012 6.7191260 0.003375496 0.163261341 0.279410735 10 7576598 7576891 294 - 0.742 0.901 0.623
ENSG00000123243 E013 3.4373620 0.005049710 0.751738933 0.838113061 10 7576892 7577012 121 - 0.672 0.612 -0.260
ENSG00000123243 E014 0.0000000       10 7578296 7578704 409 -      
ENSG00000123243 E015 4.1286643 0.003989470 0.284219392 0.424447107 10 7579755 7580064 310 - 0.589 0.731 0.606
ENSG00000123243 E016 4.1118262 0.133550636 0.363803449 0.508238803 10 7585901 7586069 169 - 0.587 0.733 0.621
ENSG00000123243 E017 0.0000000       10 7600529 7600565 37 -      
ENSG00000123243 E018 0.0000000       10 7609420 7609494 75 -      
ENSG00000123243 E019 3.3097789 0.027011755 0.254208173 0.390856361 10 7615982 7616098 117 - 0.485 0.664 0.816
ENSG00000123243 E020 3.1196460 0.100374121 0.218873567 0.349046177 10 7617113 7617266 154 - 0.741 0.489 -1.114
ENSG00000123243 E021 1.0265905 0.192797864 0.004703918 0.015107194 10 7617267 7617282 16 - 0.588 0.000 -13.726
ENSG00000123243 E022 0.0000000       10 7617283 7619580 2298 -      
ENSG00000123243 E023 0.0000000       10 7619581 7619660 80 -      
ENSG00000123243 E024 0.6330284 0.068443465 0.684403694 0.787391762 10 7619661 7622477 2817 - 0.261 0.180 -0.680
ENSG00000123243 E025 3.9136280 0.006145741 0.022540306 0.056804125 10 7637228 7637478 251 - 0.855 0.521 -1.410
ENSG00000123243 E026 1.4812479 0.100100388 0.141930415 0.250673957 10 7640754 7640779 26 - 0.540 0.250 -1.663
ENSG00000123243 E027 2.1110421 0.007243862 0.030507092 0.072963983 10 7640780 7640855 76 - 0.672 0.308 -1.843
ENSG00000123243 E028 2.3605008 0.006453672 0.033748414 0.079250774 10 7641927 7642090 164 - 0.708 0.359 -1.674
ENSG00000123243 E029 1.6241419 0.008993816 0.505204041 0.641020492 10 7655631 7655675 45 - 0.485 0.359 -0.674
ENSG00000123243 E030 1.6952176 0.009132097 0.505812613 0.641538506 10 7666803 7666966 164 - 0.485 0.360 -0.673
ENSG00000123243 E031 0.1472490 0.043128720 0.328248763   10 7666967 7666998 32 - 0.150 0.000 -11.720