ENSG00000123200

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000679008 ENSG00000123200 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H13 protein_coding protein_coding 22.8065 9.817118 29.99674 1.049964 0.1514362 1.610446 4.0849029 2.60948376 5.060772 0.46496609 0.1673503 0.9529230 0.19680000 0.270633333 0.16863333 -0.10200000 2.619462e-01 5.56573e-11 FALSE  
MSTRG.8709.10 ENSG00000123200 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H13 protein_coding   22.8065 9.817118 29.99674 1.049964 0.1514362 1.610446 3.0219186 0.22536972 4.294830 0.22536972 0.3328413 4.1929556 0.11229583 0.019366667 0.14320000 0.12383333 6.061161e-02 5.56573e-11 FALSE  
MSTRG.8709.11 ENSG00000123200 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H13 protein_coding   22.8065 9.817118 29.99674 1.049964 0.1514362 1.610446 1.9609143 0.00000000 2.939726 0.00000000 0.5994458 8.2044370 0.06878333 0.000000000 0.09803333 0.09803333 5.565730e-11 5.56573e-11 FALSE  
MSTRG.8709.21 ENSG00000123200 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H13 protein_coding   22.8065 9.817118 29.99674 1.049964 0.1514362 1.610446 1.2165116 0.00000000 2.054557 0.00000000 0.5046312 7.6896886 0.03488333 0.000000000 0.06833333 0.06833333 3.979333e-07 5.56573e-11 FALSE  
MSTRG.8709.23 ENSG00000123200 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H13 protein_coding   22.8065 9.817118 29.99674 1.049964 0.1514362 1.610446 1.5479132 0.00000000 2.803877 0.00000000 0.5856792 8.1364153 0.04950417 0.000000000 0.09330000 0.09330000 1.303354e-09 5.56573e-11 FALSE  
MSTRG.8709.26 ENSG00000123200 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H13 protein_coding   22.8065 9.817118 29.99674 1.049964 0.1514362 1.610446 0.4973692 0.07347326 1.888026 0.07347326 0.1549273 4.5070423 0.01750417 0.009166667 0.06296667 0.05380000 5.900458e-02 5.56573e-11 FALSE  
MSTRG.8709.4 ENSG00000123200 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H13 protein_coding   22.8065 9.817118 29.99674 1.049964 0.1514362 1.610446 0.2347381 0.45010693 0.000000 0.24397776 0.0000000 -5.5238973 0.01931667 0.052333333 0.00000000 -0.05233333 7.376500e-02 5.56573e-11 FALSE  
MSTRG.8709.6 ENSG00000123200 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H13 protein_coding   22.8065 9.817118 29.99674 1.049964 0.1514362 1.610446 2.4158218 2.91717452 1.814668 0.57874303 1.0434848 -0.6818749 0.15207500 0.296266667 0.06060000 -0.23566667 2.831931e-01 5.56573e-11 FALSE  
MSTRG.8709.9 ENSG00000123200 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H13 protein_coding   22.8065 9.817118 29.99674 1.049964 0.1514362 1.610446 2.9382503 2.02575734 2.625679 0.60597286 0.7459626 0.3726089 0.14637500 0.201200000 0.08760000 -0.11360000 1.418580e-01 5.56573e-11 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123200 E001 20.7099036 0.0278243338 9.799657e-07 8.144041e-06 13 45954465 45954593 129 - 1.045 1.600 1.942
ENSG00000123200 E002 27.7499613 0.0256728058 8.315084e-07 7.026172e-06 13 45954594 45954645 52 - 1.188 1.707 1.795
ENSG00000123200 E003 35.8729326 0.0334488610 1.186123e-03 4.594116e-03 13 45954646 45954710 65 - 1.384 1.754 1.266
ENSG00000123200 E004 194.3585018 0.0115244692 5.899218e-03 1.834504e-02 13 45954711 45956075 1365 - 2.202 2.374 0.576
ENSG00000123200 E005 208.3296932 0.0087376442 3.069880e-09 4.155921e-08 13 45956076 45956737 662 - 2.164 2.478 1.048
ENSG00000123200 E006 171.7020359 0.0016684232 1.345508e-24 1.414076e-22 13 45956738 45956871 134 - 2.062 2.412 1.170
ENSG00000123200 E007 95.0532112 0.0017216052 3.297923e-19 1.923589e-17 13 45956872 45956920 49 - 1.790 2.170 1.277
ENSG00000123200 E008 78.9172221 0.0019719485 7.376857e-17 3.226046e-15 13 45956921 45956958 38 - 1.705 2.091 1.301
ENSG00000123200 E009 56.0641575 0.0038809604 3.016842e-10 4.907536e-09 13 45956959 45956962 4 - 1.572 1.934 1.225
ENSG00000123200 E010 83.9997573 0.0003561137 4.667272e-17 2.088828e-15 13 45956963 45956978 16 - 1.753 2.096 1.153
ENSG00000123200 E011 81.3262854 0.0003255962 7.805365e-16 2.989695e-14 13 45956979 45956996 18 - 1.745 2.079 1.122
ENSG00000123200 E012 275.7893540 0.0001918684 3.625537e-19 2.104311e-17 13 45956997 45957297 301 - 2.333 2.544 0.701
ENSG00000123200 E013 214.8651411 0.0007850146 2.560743e-06 1.946886e-05 13 45959483 45959646 164 - 2.254 2.397 0.479
ENSG00000123200 E014 3.8675826 0.0041339866 1.353611e-01 2.416177e-01 13 45962176 45963841 1666 - 0.579 0.808 0.957
ENSG00000123200 E015 208.8450353 0.0018253863 1.052061e-05 6.959386e-05 13 45963842 45964042 201 - 2.238 2.393 0.518
ENSG00000123200 E016 210.6151283 0.0002247339 1.850097e-05 1.156865e-04 13 45965280 45965429 150 - 2.257 2.379 0.410
ENSG00000123200 E017 64.8718372 0.0003775912 3.580879e-01 5.024715e-01 13 45965430 45965432 3 - 1.777 1.833 0.187
ENSG00000123200 E018 450.1132831 0.0001545404 4.658384e-01 6.054506e-01 13 45967504 45968028 525 - 2.622 2.649 0.088
ENSG00000123200 E019 617.9410440 0.0001128643 5.239003e-05 2.937125e-04 13 45968748 45969971 1224 - 2.784 2.737 -0.157
ENSG00000123200 E020 108.4002133 0.0003119443 8.679952e-05 4.600798e-04 13 45970362 45970465 104 - 2.058 1.923 -0.451
ENSG00000123200 E021 336.6775717 0.0021017182 2.000857e-09 2.800564e-08 13 45975283 45975838 556 - 2.557 2.392 -0.549
ENSG00000123200 E022 13.8642697 0.0257940732 9.880345e-01 9.965616e-01 13 45976182 45976265 84 - 1.150 1.155 0.016
ENSG00000123200 E023 164.2829583 0.0002995315 7.824867e-14 2.260097e-12 13 45979813 45980004 192 - 2.261 2.037 -0.750
ENSG00000123200 E024 288.2228650 0.0002032511 7.115030e-32 1.353334e-29 13 45985297 45985761 465 - 2.515 2.242 -0.911
ENSG00000123200 E025 215.7454713 0.0001822416 2.941619e-28 4.254052e-26 13 45988787 45989097 311 - 2.395 2.098 -0.995
ENSG00000123200 E026 14.7808588 0.0018234509 3.588686e-01 5.032404e-01 13 46001163 46001460 298 - 1.199 1.125 -0.267
ENSG00000123200 E027 129.9591313 0.0003446122 3.774964e-13 9.895607e-12 13 46003139 46003336 198 - 2.164 1.916 -0.834
ENSG00000123200 E028 1.6857544 0.0612501329 5.668489e-01 6.937287e-01 13 46010150 46010347 198 - 0.359 0.476 0.628
ENSG00000123200 E029 113.0737635 0.0120206200 1.368168e-04 6.894409e-04 13 46010348 46010505 158 - 2.100 1.869 -0.774
ENSG00000123200 E030 119.6645973 0.0003987417 4.310629e-08 4.710363e-07 13 46011415 46011554 140 - 2.113 1.924 -0.635
ENSG00000123200 E031 0.3289534 0.0283843945 5.594586e-01   13 46011555 46011555 1 - 0.085 0.174 1.198
ENSG00000123200 E032 108.6468246 0.0006056603 3.415566e-17 1.555080e-15 13 46020449 46020557 109 - 2.106 1.769 -1.133
ENSG00000123200 E033 0.1451727 0.0425914612 1.000000e+00   13 46042157 46042163 7 - 0.085 0.000 -7.624
ENSG00000123200 E034 99.8564093 0.0003075276 4.776048e-20 3.047518e-18 13 46042164 46042275 112 - 2.078 1.697 -1.281
ENSG00000123200 E035 83.5164188 0.0003358682 1.081855e-11 2.241407e-10 13 46044955 46045064 110 - 1.986 1.693 -0.989
ENSG00000123200 E036 86.6600848 0.0124472153 7.274659e-06 4.988281e-05 13 46045391 46045513 123 - 2.005 1.703 -1.020
ENSG00000123200 E037 27.4272458 0.0360740504 9.389278e-03 2.725417e-02 13 46045514 46045516 3 - 1.511 1.227 -0.987
ENSG00000123200 E038 17.0588287 0.0019745445 6.114671e-05 3.371184e-04 13 46051932 46051986 55 - 1.335 0.949 -1.387
ENSG00000123200 E039 9.4130157 0.0033384830 1.111990e-03 4.343702e-03 13 46051987 46051989 3 - 1.100 0.694 -1.557
ENSG00000123200 E040 46.4745667 0.0650843747 2.343170e-02 5.864721e-02 13 46052404 46052697 294 - 1.729 1.469 -0.887
ENSG00000123200 E041 37.8881649 0.0257022592 4.090986e-03 1.339761e-02 13 46052698 46052776 79 - 1.643 1.376 -0.916