ENSG00000123191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000242839 ENSG00000123191 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP7B protein_coding protein_coding 9.036909 7.859708 8.340037 0.6468323 0.3500456 0.08547247 5.1503266 4.2950760 5.2911308 0.7192775 0.4757877 0.3002614 0.56970833 0.5417667 0.6395 0.09773333 6.506943e-01 7.187765e-14 FALSE TRUE
ENST00000673772 ENSG00000123191 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP7B protein_coding protein_coding 9.036909 7.859708 8.340037 0.6468323 0.3500456 0.08547247 0.2318446 0.0000000 0.4584122 0.0000000 0.2383914 5.5497068 0.02542083 0.0000000 0.0535 0.05350000 1.854818e-01 7.187765e-14 FALSE TRUE
ENST00000673923 ENSG00000123191 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP7B protein_coding retained_intron 9.036909 7.859708 8.340037 0.6468323 0.3500456 0.08547247 0.3298185 0.8619365 0.0000000 0.2901286 0.0000000 -6.4461512 0.04108750 0.1121333 0.0000 -0.11213333 3.306597e-07 7.187765e-14 FALSE TRUE
ENST00000674147 ENSG00000123191 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP7B protein_coding protein_coding 9.036909 7.859708 8.340037 0.6468323 0.3500456 0.08547247 0.4381964 0.8602688 0.1137594 0.1001455 0.1137594 -2.8139229 0.04882917 0.1107000 0.0126 -0.09810000 4.473341e-02 7.187765e-14 FALSE TRUE
MSTRG.8817.10 ENSG00000123191 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP7B protein_coding   9.036909 7.859708 8.340037 0.6468323 0.3500456 0.08547247 0.5905388 0.8101972 0.0000000 0.1524820 0.0000000 -6.3578989 0.06580000 0.1015333 0.0000 -0.10153333 7.187765e-14 7.187765e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123191 E001 1.2512805 0.0105403094 2.810390e-01 4.209021e-01 13 51923261 51923393 133 - 0.223 0.412 1.243
ENSG00000123191 E002 0.4428904 0.5708728220 3.440724e-01 4.881232e-01 13 51924295 51924387 93 - 0.000 0.224 11.508
ENSG00000123191 E003 0.2214452 0.0407788215 5.044656e-01   13 51930436 51930564 129 - 0.000 0.120 11.538
ENSG00000123191 E004 3.1970020 0.0560127385 9.470034e-01 9.707223e-01 13 51932352 51932468 117 - 0.603 0.622 0.083
ENSG00000123191 E005 0.9661334 0.1969751775 1.877147e-01 3.108592e-01 13 51932669 51932673 5 - 0.126 0.406 2.205
ENSG00000123191 E006 1.4099687 0.2633877963 3.151766e-01 4.579282e-01 13 51932674 51932679 6 - 0.223 0.494 1.660
ENSG00000123191 E007 1.2584533 0.3576002533 1.738978e-01 2.932590e-01 13 51932680 51932683 4 - 0.125 0.491 2.650
ENSG00000123191 E008 4.6788714 0.0226651846 1.424237e-05 9.128714e-05 13 51932684 51932703 20 - 0.222 0.949 3.558
ENSG00000123191 E009 4.5295341 0.0091195124 8.418482e-05 4.478549e-04 13 51932704 51932704 1 - 0.302 0.918 2.857
ENSG00000123191 E010 8.1861487 0.0396705998 2.297687e-04 1.090870e-03 13 51932705 51932751 47 - 0.566 1.125 2.205
ENSG00000123191 E011 98.4438188 0.0019802061 1.810752e-18 9.660418e-17 13 51932752 51933068 317 - 1.747 2.122 1.258
ENSG00000123191 E012 63.4202563 0.0024540090 1.176977e-12 2.854625e-11 13 51933069 51933137 69 - 1.562 1.931 1.247
ENSG00000123191 E013 110.3205614 0.0006888430 2.734677e-21 2.022946e-19 13 51933138 51933317 180 - 1.819 2.166 1.164
ENSG00000123191 E014 293.6355396 0.0004247051 1.892359e-19 1.137378e-17 13 51933318 51934244 927 - 2.348 2.543 0.650
ENSG00000123191 E015 55.8734772 0.0007942158 8.360413e-02 1.651840e-01 13 51934245 51934289 45 - 1.703 1.784 0.273
ENSG00000123191 E016 117.6839769 0.0003317054 5.726148e-01 6.986906e-01 13 51934290 51934603 314 - 2.062 2.078 0.053
ENSG00000123191 E017 47.0539836 0.0006235710 7.806851e-01 8.590905e-01 13 51934604 51934685 82 - 1.683 1.665 -0.059
ENSG00000123191 E018 23.5882781 0.0009621887 6.560753e-01 7.658025e-01 13 51934686 51934690 5 - 1.400 1.365 -0.120
ENSG00000123191 E019 23.1465191 0.0022457490 6.148280e-01 7.332212e-01 13 51934691 51934692 2 - 1.394 1.353 -0.140
ENSG00000123191 E020 44.8170791 0.0016053156 6.300835e-01 7.453284e-01 13 51934693 51934755 63 - 1.671 1.641 -0.100
ENSG00000123191 E021 94.1709543 0.0037374470 7.636457e-02 1.536872e-01 13 51934756 51935029 274 - 1.931 2.009 0.262
ENSG00000123191 E022 42.8830709 0.0055782187 6.200504e-04 2.606895e-03 13 51935593 51935695 103 - 1.507 1.729 0.756
ENSG00000123191 E023 54.1085895 0.0005838012 1.368413e-03 5.203879e-03 13 51937276 51937393 118 - 1.648 1.802 0.519
ENSG00000123191 E024 0.0000000       13 51937394 51937475 82 -      
ENSG00000123191 E025 86.1434828 0.0003208137 4.358316e-01 5.779897e-01 13 51937476 51937679 204 - 1.922 1.949 0.090
ENSG00000123191 E026 75.8198384 0.0004969819 1.704755e-01 2.887704e-01 13 51939051 51939193 143 - 1.912 1.853 -0.198
ENSG00000123191 E027 0.5149242 0.1547278763 6.409428e-01 7.540595e-01 13 51939194 51939990 797 - 0.125 0.214 0.923
ENSG00000123191 E028 0.2903454 0.3260697486 2.653597e-01   13 51940046 51941080 1035 - 0.222 0.000 -12.460
ENSG00000123191 E029 81.6152673 0.0058789766 7.195309e-01 8.143338e-01 13 51941081 51941224 144 - 1.928 1.902 -0.085
ENSG00000123191 E030 81.0970732 0.0004068042 4.237394e-01 5.667820e-01 13 51942386 51942554 169 - 1.931 1.897 -0.115
ENSG00000123191 E031 50.2154728 0.0004923226 1.091679e-01 2.043166e-01 13 51944109 51944191 83 - 1.752 1.671 -0.276
ENSG00000123191 E032 55.6177395 0.0085811512 6.648520e-01 7.726028e-01 13 51944192 51944291 100 - 1.770 1.737 -0.110
ENSG00000123191 E033 8.5935309 0.0323172372 1.269452e-01 2.298958e-01 13 51944292 51946283 1992 - 1.081 0.867 -0.799
ENSG00000123191 E034 63.9316119 0.0107132598 1.917924e-01 3.160043e-01 13 51946284 51946478 195 - 1.860 1.769 -0.309
ENSG00000123191 E035 5.7260602 0.0029464248 3.299219e-02 7.779020e-02 13 51946479 51947850 1372 - 0.956 0.681 -1.080
ENSG00000123191 E036 0.2903454 0.3260697486 2.653597e-01   13 51947851 51947870 20 - 0.222 0.000 -12.460
ENSG00000123191 E037 3.7634911 0.0138849115 8.632230e-06 5.820372e-05 13 51947871 51949661 1791 - 0.939 0.213 -3.603
ENSG00000123191 E038 35.3710481 0.0015206092 2.075338e-01 3.355265e-01 13 51949662 51949715 54 - 1.600 1.522 -0.265
ENSG00000123191 E039 45.8489358 0.0005035621 6.083565e-02 1.280442e-01 13 51949716 51949796 81 - 1.718 1.618 -0.337
ENSG00000123191 E040 64.3089321 0.0004448140 5.309128e-01 6.634347e-01 13 51950007 51950161 155 - 1.828 1.797 -0.102
ENSG00000123191 E041 63.9115920 0.0003695533 7.896822e-01 8.654221e-01 13 51950272 51950399 128 - 1.806 1.815 0.030
ENSG00000123191 E042 53.6658624 0.0038659756 9.476741e-01 9.710893e-01 13 51957516 51957607 92 - 1.739 1.734 -0.019
ENSG00000123191 E043 1.9520631 0.0074821581 6.286544e-01 7.441590e-01 13 51957608 51958310 703 - 0.427 0.507 0.404
ENSG00000123191 E044 36.2557847 0.0011130404 2.571627e-01 3.942089e-01 13 51958311 51958363 53 - 1.604 1.535 -0.236
ENSG00000123191 E045 34.9478319 0.0013738517 9.321748e-01 9.612853e-01 13 51958364 51958400 37 - 1.558 1.550 -0.026
ENSG00000123191 E046 46.1828559 0.0011858100 2.132048e-01 3.423180e-01 13 51958401 51958544 144 - 1.709 1.641 -0.232
ENSG00000123191 E047 9.1736260 0.0018351625 1.345089e-01 2.404159e-01 13 51958545 51960147 1603 - 1.081 0.918 -0.600
ENSG00000123191 E048 47.3661335 0.0034755257 1.056585e-01 1.990975e-01 13 51960148 51960322 175 - 1.734 1.638 -0.327
ENSG00000123191 E049 29.6648687 0.0006678669 9.808817e-03 2.829093e-02 13 51961837 51961913 77 - 1.570 1.404 -0.568
ENSG00000123191 E050 0.0000000       13 51964780 51964871 92 -      
ENSG00000123191 E051 38.0307378 0.0007266206 6.205366e-04 2.608592e-03 13 51964872 51964923 52 - 1.692 1.496 -0.666
ENSG00000123191 E052 48.9475520 0.0004452868 4.978377e-04 2.151860e-03 13 51964924 51965033 110 - 1.787 1.611 -0.595
ENSG00000123191 E053 54.5407883 0.0004458610 2.430887e-07 2.292420e-06 13 51968444 51968607 164 - 1.863 1.615 -0.840
ENSG00000123191 E054 0.4031496 0.0249245459 2.115287e-01 3.402994e-01 13 51968880 51969169 290 - 0.000 0.213 12.683
ENSG00000123191 E055 0.7697675 0.0689647795 3.437528e-01 4.878196e-01 13 51969170 51969463 294 - 0.125 0.292 1.520
ENSG00000123191 E056 0.9513727 0.0141455567 9.514504e-01 9.736334e-01 13 51969464 51970491 1028 - 0.302 0.290 -0.081
ENSG00000123191 E057 63.5699356 0.0004516135 9.903677e-07 8.223994e-06 13 51970492 51970745 254 - 1.915 1.697 -0.738
ENSG00000123191 E058 16.9475534 0.0030803358 5.601750e-02 1.197282e-01 13 51970746 51970749 4 - 1.337 1.174 -0.576
ENSG00000123191 E059 0.0000000       13 51971074 51971118 45 -      
ENSG00000123191 E060 0.3299976 0.0274424043 2.136757e-01   13 51972595 51972832 238 - 0.000 0.213 12.650
ENSG00000123191 E061 43.9586223 0.0004801137 8.623155e-05 4.573691e-04 13 51973935 51974084 150 - 1.755 1.546 -0.709
ENSG00000123191 E062 70.0873833 0.0003631288 1.515234e-07 1.486416e-06 13 51974085 51974417 333 - 1.959 1.736 -0.751
ENSG00000123191 E063 125.9869843 0.0106182157 6.650450e-06 4.603733e-05 13 51974418 51975013 596 - 2.224 1.969 -0.855
ENSG00000123191 E064 52.4014564 0.0038380561 1.746666e-05 1.097879e-04 13 51975014 51975168 155 - 1.840 1.596 -0.828
ENSG00000123191 E065 0.0000000       13 51977406 51977614 209 -      
ENSG00000123191 E066 0.0000000       13 51978820 51978991 172 -      
ENSG00000123191 E067 31.3922073 0.0033438383 8.889977e-04 3.575829e-03 13 52011287 52011391 105 - 1.618 1.394 -0.770
ENSG00000123191 E068 32.5746124 0.0035673625 1.264677e-06 1.027707e-05 13 52011392 52011590 199 - 1.677 1.352 -1.113
ENSG00000123191 E069 8.8330099 0.0160954983 3.667909e-03 1.220448e-02 13 52012020 52012193 174 - 1.147 0.785 -1.356