ENSG00000123159

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345425 ENSG00000123159 HEK293_OSMI2_2hA HEK293_TMG_2hB GIPC1 protein_coding protein_coding 126.8309 240.3624 67.02748 10.92344 1.102387 -1.842232 5.850509 9.261867 1.622132 2.4318150 0.4791775 -2.5061021 0.05104167 0.03790000 0.0240000 -0.01390000 0.547383868 0.000287861 FALSE  
ENST00000393028 ENSG00000123159 HEK293_OSMI2_2hA HEK293_TMG_2hB GIPC1 protein_coding protein_coding 126.8309 240.3624 67.02748 10.92344 1.102387 -1.842232 33.525803 73.378886 13.790640 0.4158428 2.8322033 -2.4108264 0.23289583 0.30656667 0.2064000 -0.10016667 0.303284629 0.000287861 FALSE  
ENST00000393033 ENSG00000123159 HEK293_OSMI2_2hA HEK293_TMG_2hB GIPC1 protein_coding protein_coding 126.8309 240.3624 67.02748 10.92344 1.102387 -1.842232 64.444749 126.717317 33.223579 6.6632299 0.8594125 -1.9310140 0.50203333 0.52686667 0.4958000 -0.03106667 0.426454466 0.000287861 FALSE  
ENST00000586027 ENSG00000123159 HEK293_OSMI2_2hA HEK293_TMG_2hB GIPC1 protein_coding protein_coding 126.8309 240.3624 67.02748 10.92344 1.102387 -1.842232 13.672447 18.989748 11.018209 2.7721932 1.0919618 -0.7847817 0.12423750 0.07896667 0.1639333 0.08496667 0.002373028 0.000287861 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123159 E001 2.5151316 0.0092965560 6.984110e-01 7.983868e-01 19 14477760 14477761 2 - 0.377 0.454 0.418
ENSG00000123159 E002 6.0826123 0.0053510941 8.177311e-01 8.847530e-01 19 14477762 14477763 2 - 0.711 0.748 0.151
ENSG00000123159 E003 1071.9600998 0.0006701795 4.396132e-04 1.926653e-03 19 14477764 14478003 240 - 2.832 2.900 0.227
ENSG00000123159 E004 664.4979972 0.0009178929 4.505664e-04 1.968780e-03 19 14478004 14478020 17 - 2.609 2.695 0.285
ENSG00000123159 E005 968.0310941 0.0008136541 5.076230e-04 2.188563e-03 19 14478021 14478085 65 - 2.783 2.856 0.243
ENSG00000123159 E006 1432.7306483 0.0010761517 1.510020e-05 9.633147e-05 19 14478086 14478217 132 - 2.941 3.029 0.290
ENSG00000123159 E007 812.0804169 0.0020966592 3.762055e-03 1.247480e-02 19 14478218 14478245 28 - 2.700 2.782 0.270
ENSG00000123159 E008 716.4752070 0.0038518225 1.445922e-03 5.459514e-03 19 14478246 14478255 10 - 2.619 2.732 0.375
ENSG00000123159 E009 2622.4427017 0.0008423164 2.389689e-01 3.729339e-01 19 14478256 14478567 312 - 3.261 3.281 0.067
ENSG00000123159 E010 1179.3321372 0.0010177378 3.925048e-01 5.364760e-01 19 14478684 14478765 82 - 2.943 2.928 -0.050
ENSG00000123159 E011 1316.6266130 0.0004828414 2.224627e-01 3.533274e-01 19 14479412 14479524 113 - 2.992 2.975 -0.059
ENSG00000123159 E012 4.1413538 0.0048410979 3.001558e-04 1.380218e-03 19 14479525 14479817 293 - 0.999 0.476 -2.170
ENSG00000123159 E013 1.1018559 0.0176873236 1.378555e-01 2.450924e-01 19 14479818 14480304 487 - 0.487 0.208 -1.755
ENSG00000123159 E014 557.9421802 0.0009881266 7.154725e-01 8.113689e-01 19 14480305 14480305 1 - 2.611 2.603 -0.026
ENSG00000123159 E015 1742.1268547 0.0011828628 2.385744e-04 1.127253e-03 19 14480306 14480485 180 - 3.155 3.089 -0.218
ENSG00000123159 E016 5.8542427 0.1339527796 6.242409e-01 7.406376e-01 19 14480486 14480592 107 - 0.766 0.692 -0.302
ENSG00000123159 E017 1734.9532694 0.0023019600 1.199062e-05 7.823344e-05 19 14480593 14480778 186 - 3.183 3.082 -0.337
ENSG00000123159 E018 5.8280571 0.0028289499 9.952563e-01 1.000000e+00 19 14480779 14480896 118 - 0.711 0.712 0.002
ENSG00000123159 E019 16.1595440 0.0269897329 1.568569e-02 4.203240e-02 19 14481747 14482688 942 - 1.336 1.042 -1.047
ENSG00000123159 E020 938.5622881 0.0007088660 1.767810e-01 2.970528e-01 19 14482689 14482855 167 - 2.852 2.827 -0.084
ENSG00000123159 E021 176.4944595 0.0116477990 1.294779e-04 6.565454e-04 19 14482856 14482856 1 - 1.883 2.140 0.864
ENSG00000123159 E022 670.8231907 0.0050348926 6.699716e-02 1.383791e-01 19 14482857 14483006 150 - 2.626 2.697 0.238
ENSG00000123159 E023 11.4258048 0.0115092985 5.763000e-02 1.225580e-01 19 14483007 14483330 324 - 0.711 1.002 1.128
ENSG00000123159 E024 3.7576783 0.0728827548 9.802979e-01 9.916885e-01 19 14483331 14483463 133 - 0.575 0.574 -0.006
ENSG00000123159 E025 7.9888393 0.0162346970 7.735543e-01 8.538883e-01 19 14483489 14483579 91 - 0.858 0.816 -0.160
ENSG00000123159 E026 518.2860309 0.0001598832 4.501771e-06 3.238577e-05 19 14491656 14491743 88 - 2.651 2.558 -0.310
ENSG00000123159 E027 227.5504612 0.0001832084 1.247753e-07 1.244515e-06 19 14492857 14492912 56 - 2.345 2.190 -0.517
ENSG00000123159 E028 0.2998086 0.0292934367 2.749098e-01   19 14495505 14495592 88 - 0.228 0.062 -2.172
ENSG00000123159 E029 1.2167234 0.0104937928 7.907818e-01 8.662100e-01 19 14495923 14496036 114 - 0.228 0.283 0.416
ENSG00000123159 E030 141.4236201 0.0002672291 1.880800e-23 1.755231e-21 19 14496037 14496149 113 - 2.279 1.937 -1.146