ENSG00000123143

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000242783 ENSG00000123143 HEK293_OSMI2_2hA HEK293_TMG_2hB PKN1 protein_coding protein_coding 97.5233 184.7678 50.79348 8.017469 1.115786 -1.862792 28.64582 41.78637 22.14713 6.061615 2.573839 -0.9156063 0.3064792 0.2246333 0.4342333 0.2096000 0.004348684 1.398283e-09 FALSE TRUE
ENST00000342216 ENSG00000123143 HEK293_OSMI2_2hA HEK293_TMG_2hB PKN1 protein_coding protein_coding 97.5233 184.7678 50.79348 8.017469 1.115786 -1.862792 63.66126 131.15180 26.69770 6.419875 1.695935 -2.2960197 0.6416917 0.7103333 0.5275000 -0.1828333 0.018854064 1.398283e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123143 E001 3.2755376 1.281486e-01 2.809152e-01 4.207732e-01 19 14433053 14433170 118 + 0.700 0.473 -1.024
ENSG00000123143 E002 1.2103712 4.022842e-01 1.234756e-02 3.436627e-02 19 14433306 14433322 17 + 0.753 0.064 -4.875
ENSG00000123143 E003 16.0902428 1.466249e-02 7.874313e-42 3.082159e-39 19 14433323 14433399 77 + 1.827 0.356 -5.703
ENSG00000123143 E004 18.0445832 2.599272e-02 8.756971e-31 1.557730e-28 19 14433400 14433418 19 + 1.848 0.510 -4.956
ENSG00000123143 E005 62.9906859 1.717555e-02 6.278162e-09 8.045585e-08 19 14433419 14433483 65 + 2.019 1.557 -1.561
ENSG00000123143 E006 65.0232922 1.479949e-02 5.322285e-05 2.978615e-04 19 14433484 14433492 9 + 1.927 1.619 -1.042
ENSG00000123143 E007 150.0666149 1.058085e-02 4.448354e-04 1.946927e-03 19 14433493 14433542 50 + 2.218 2.004 -0.717
ENSG00000123143 E008 2.0608059 1.309656e-02 1.386399e-04 6.976260e-04 19 14434590 14434654 65 + 0.846 0.213 -3.248
ENSG00000123143 E009 0.8114974 5.272770e-02 1.000000e+00 1.000000e+00 19 14440260 14440329 70 + 0.222 0.212 -0.086
ENSG00000123143 E010 0.2965864 2.283345e-01 1.000000e+00   19 14440373 14440402 30 + 0.001 0.117 7.155
ENSG00000123143 E011 588.8363635 8.919029e-03 1.747357e-04 8.557989e-04 19 14441143 14441443 301 + 2.785 2.604 -0.603
ENSG00000123143 E012 683.8581990 2.398783e-03 1.737410e-05 1.092749e-04 19 14443470 14443621 152 + 2.805 2.680 -0.416
ENSG00000123143 E013 1.9530928 7.583640e-03 9.228660e-01 9.553572e-01 19 14446409 14446425 17 + 0.369 0.385 0.092
ENSG00000123143 E014 799.9070157 1.381511e-03 9.170991e-03 2.671141e-02 19 14446426 14446561 136 + 2.824 2.760 -0.214
ENSG00000123143 E015 799.0017478 2.285347e-03 9.702359e-02 1.859241e-01 19 14450318 14450463 146 + 2.811 2.763 -0.160
ENSG00000123143 E016 4.1546145 3.920964e-03 1.374146e-01 2.444807e-01 19 14450806 14450895 90 + 0.803 0.567 -0.992
ENSG00000123143 E017 982.9342794 4.135190e-03 1.345155e-01 2.404246e-01 19 14450896 14451109 214 + 2.903 2.852 -0.169
ENSG00000123143 E018 1136.1633702 1.643861e-03 1.566073e-02 4.198155e-02 19 14451829 14452023 195 + 2.972 2.914 -0.195
ENSG00000123143 E019 959.1594202 9.142261e-05 9.155316e-03 2.667067e-02 19 14458031 14458140 110 + 2.884 2.840 -0.146
ENSG00000123143 E020 1157.9000620 9.002067e-05 2.424395e-03 8.535326e-03 19 14458232 14458375 144 + 2.968 2.922 -0.154
ENSG00000123143 E021 2.2767476 6.663057e-03 7.128286e-01 8.094244e-01 19 14463543 14463666 124 + 0.369 0.438 0.381
ENSG00000123143 E022 814.6838301 6.453655e-04 1.950505e-01 3.200476e-01 19 14463667 14463742 76 + 2.802 2.773 -0.097
ENSG00000123143 E023 786.8746617 5.864732e-04 7.442453e-01 8.326348e-01 19 14463828 14463874 47 + 2.759 2.763 0.011
ENSG00000123143 E024 993.4218596 1.044893e-04 1.701545e-01 2.883865e-01 19 14463875 14463969 95 + 2.849 2.865 0.054
ENSG00000123143 E025 1050.1469411 7.953439e-04 3.071066e-01 4.492990e-01 19 14464060 14464153 94 + 2.874 2.891 0.058
ENSG00000123143 E026 5.6753217 4.260561e-03 2.750784e-01 4.143235e-01 19 14467486 14467564 79 + 0.565 0.747 0.778
ENSG00000123143 E027 955.7758238 5.474269e-04 2.311434e-01 3.638349e-01 19 14467565 14467621 57 + 2.831 2.850 0.063
ENSG00000123143 E028 672.1517446 1.136440e-03 4.409186e-02 9.855084e-02 19 14467622 14467641 20 + 2.656 2.702 0.153
ENSG00000123143 E029 10.9663878 1.588240e-03 6.510414e-03 1.994854e-02 19 14467642 14467717 76 + 1.196 0.893 -1.112
ENSG00000123143 E030 984.2787902 8.948678e-04 9.913288e-01 9.986481e-01 19 14467718 14467793 76 + 2.863 2.860 -0.009
ENSG00000123143 E031 10.9080982 1.598207e-03 6.468561e-03 1.984052e-02 19 14467794 14467875 82 + 1.196 0.893 -1.112
ENSG00000123143 E032 1228.9534096 4.366467e-04 3.878002e-01 5.319382e-01 19 14467876 14467967 92 + 2.947 2.958 0.036
ENSG00000123143 E033 1671.8608126 7.994353e-05 6.251295e-01 7.413158e-01 19 14469341 14469517 177 + 3.099 3.089 -0.034
ENSG00000123143 E034 7.5754135 2.306883e-02 9.243196e-03 2.689359e-02 19 14469518 14469751 234 + 1.092 0.725 -1.398
ENSG00000123143 E035 1127.0444141 7.370102e-04 8.985178e-01 9.392827e-01 19 14469752 14469814 63 + 2.921 2.921 -0.001
ENSG00000123143 E036 9.3959289 1.919270e-02 2.656259e-01 4.036970e-01 19 14469815 14469911 97 + 1.016 0.859 -0.588
ENSG00000123143 E037 1351.9398955 1.369978e-03 3.563380e-01 5.007170e-01 19 14469912 14469988 77 + 3.018 2.997 -0.071
ENSG00000123143 E038 883.4738837 2.302263e-03 9.397500e-01 9.661620e-01 19 14470163 14470174 12 + 2.819 2.815 -0.012
ENSG00000123143 E039 1116.0247131 2.418534e-03 6.262954e-01 7.422617e-01 19 14470175 14470208 34 + 2.907 2.919 0.040
ENSG00000123143 E040 1593.9498613 1.873605e-03 2.072898e-02 5.301658e-02 19 14470209 14470305 97 + 3.027 3.080 0.178
ENSG00000123143 E041 1359.7159542 2.042935e-03 5.043976e-03 1.605076e-02 19 14470575 14470631 57 + 2.943 3.013 0.233
ENSG00000123143 E042 1260.4107135 1.158211e-03 7.972587e-05 4.265770e-04 19 14470632 14470682 51 + 2.900 2.982 0.273
ENSG00000123143 E043 13.0198912 9.563886e-03 7.473368e-02 1.511049e-01 19 14470683 14470770 88 + 1.196 0.992 -0.737
ENSG00000123143 E044 889.4612055 2.054879e-03 1.300431e-02 3.592185e-02 19 14470771 14470781 11 + 2.762 2.829 0.221
ENSG00000123143 E045 1167.0760049 2.086937e-03 7.813379e-05 4.191480e-04 19 14470782 14470851 70 + 2.849 2.952 0.342
ENSG00000123143 E046 3.7997240 4.288883e-03 3.718555e-01 5.163367e-01 19 14471102 14471426 325 + 0.700 0.548 -0.663
ENSG00000123143 E047 630.0177889 6.963653e-04 9.809102e-08 9.976405e-07 19 14471581 14471596 16 + 2.563 2.685 0.406
ENSG00000123143 E048 905.2772140 2.443556e-04 9.160432e-16 3.476556e-14 19 14471597 14471867 271 + 2.703 2.844 0.469