ENSG00000123136

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000242776 ENSG00000123136 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX39A protein_coding protein_coding 152.1558 245.7425 103.3517 6.246843 1.771532 -1.249504 118.39297 213.96702 73.30277 7.9799835 0.4890315 -1.5453194 0.75140417 0.87020000 0.7096667 -0.16053333 3.963150e-09 2.052528e-13 FALSE TRUE
ENST00000589318 ENSG00000123136 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX39A protein_coding retained_intron 152.1558 245.7425 103.3517 6.246843 1.771532 -1.249504 11.33345 11.66493 10.79202 0.4589879 0.9089326 -0.1121128 0.08300417 0.04763333 0.1042667 0.05663333 4.356939e-07 2.052528e-13 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123136 E001 1.039285 2.740372e-02 6.130991e-01 7.318965e-01 19 14408754 14408797 44 - 0.192 0.290 0.767
ENSG00000123136 E002 2.987080 5.316369e-03 1.604213e-01 2.756918e-01 19 14408798 14408818 21 - 0.325 0.585 1.354
ENSG00000123136 E003 125.403528 6.112611e-03 5.825094e-03 1.815044e-02 19 14408819 14408849 31 - 1.904 2.053 0.501
ENSG00000123136 E004 705.262646 1.222647e-04 2.096955e-04 1.005293e-03 19 14408850 14408952 103 - 2.724 2.781 0.188
ENSG00000123136 E005 1531.469812 1.818650e-04 7.583154e-07 6.465954e-06 19 14409037 14409184 148 - 3.062 3.117 0.184
ENSG00000123136 E006 1804.675144 6.721629e-05 3.417073e-09 4.589212e-08 19 14409303 14409447 145 - 3.133 3.189 0.186
ENSG00000123136 E007 103.346485 6.214723e-03 8.794559e-05 4.653430e-04 19 14409448 14409535 88 - 2.094 1.879 -0.722
ENSG00000123136 E008 708.190102 1.114465e-04 1.172757e-08 1.428046e-07 19 14409536 14409538 3 - 2.700 2.790 0.300
ENSG00000123136 E009 1301.876123 9.272025e-05 1.831163e-12 4.299274e-11 19 14409539 14409645 107 - 2.970 3.052 0.274
ENSG00000123136 E010 796.626316 2.378936e-04 1.058128e-06 8.735743e-06 19 14409742 14409772 31 - 2.762 2.838 0.254
ENSG00000123136 E011 1272.524949 4.081470e-04 6.235029e-03 1.923039e-02 19 14409773 14409873 101 - 2.997 3.032 0.119
ENSG00000123136 E012 93.928805 5.012662e-03 1.164653e-12 2.826182e-11 19 14409874 14409909 36 - 2.151 1.785 -1.228
ENSG00000123136 E013 105.300376 2.626273e-03 1.763262e-13 4.846848e-12 19 14409910 14409981 72 - 2.174 1.849 -1.091
ENSG00000123136 E014 55.841498 9.542097e-04 6.374114e-12 1.370199e-10 19 14409982 14409984 3 - 1.919 1.567 -1.190
ENSG00000123136 E015 168.809786 4.936404e-03 9.885914e-22 7.628744e-20 19 14409985 14410215 231 - 2.441 2.009 -1.444
ENSG00000123136 E016 907.718179 1.216796e-04 1.474958e-01 2.582874e-01 19 14410216 14410260 45 - 2.867 2.883 0.054
ENSG00000123136 E017 951.079168 4.324038e-04 1.969369e-01 3.224001e-01 19 14410261 14410307 47 - 2.886 2.902 0.052
ENSG00000123136 E018 805.157213 9.910677e-05 7.446091e-01 8.328769e-01 19 14410308 14410334 27 - 2.827 2.827 0.000
ENSG00000123136 E019 20.793854 2.408914e-02 6.200026e-02 1.299856e-01 19 14410335 14410420 86 - 1.417 1.213 -0.712
ENSG00000123136 E020 34.024341 6.403069e-03 1.297761e-07 1.289911e-06 19 14410421 14410547 127 - 1.728 1.342 -1.321
ENSG00000123136 E021 37.399760 6.814855e-03 1.759685e-06 1.385617e-05 19 14410548 14410605 58 - 1.745 1.401 -1.178
ENSG00000123136 E022 13.264163 1.525804e-02 7.881035e-06 5.361000e-05 19 14410606 14410646 41 - 1.398 0.915 -1.730
ENSG00000123136 E023 38.065820 2.600453e-02 5.914169e-07 5.159192e-06 19 14410647 14410988 342 - 1.832 1.348 -1.655
ENSG00000123136 E024 977.351018 1.059348e-04 3.421767e-04 1.548932e-03 19 14410989 14411061 73 - 2.875 2.921 0.151
ENSG00000123136 E025 959.606217 7.570068e-05 8.245896e-05 4.396489e-04 19 14411062 14411136 75 - 2.863 2.913 0.166
ENSG00000123136 E026 690.875900 1.482609e-04 3.860501e-01 5.302363e-01 19 14411137 14411172 36 - 2.754 2.763 0.032
ENSG00000123136 E027 24.269439 7.660084e-04 8.731810e-08 8.965450e-07 19 14411173 14411217 45 - 1.596 1.209 -1.340
ENSG00000123136 E028 62.373726 3.832313e-04 1.868811e-29 2.975132e-27 19 14411218 14411505 288 - 2.060 1.544 -1.741
ENSG00000123136 E029 941.300356 9.815645e-05 1.980558e-01 3.237770e-01 19 14411506 14411542 37 - 2.912 2.889 -0.076
ENSG00000123136 E030 862.995336 8.471018e-05 3.233036e-02 7.649419e-02 19 14411543 14411559 17 - 2.884 2.848 -0.118
ENSG00000123136 E031 985.300168 7.928367e-05 2.906904e-02 7.013958e-02 19 14411560 14411598 39 - 2.941 2.907 -0.113
ENSG00000123136 E032 5.467697 1.881095e-02 8.237033e-01 8.889287e-01 19 14412359 14412550 192 - 0.780 0.743 -0.146
ENSG00000123136 E033 647.617350 1.076172e-04 1.513961e-03 5.681086e-03 19 14412551 14412560 10 - 2.776 2.719 -0.189
ENSG00000123136 E034 562.141767 1.598744e-04 4.947037e-02 1.082206e-01 19 14412561 14412561 1 - 2.702 2.662 -0.133
ENSG00000123136 E035 1037.046391 8.846438e-05 3.014606e-03 1.030825e-02 19 14412562 14412609 48 - 2.971 2.927 -0.145
ENSG00000123136 E036 1186.576682 9.664393e-05 1.877134e-03 6.844192e-03 19 14412610 14412678 69 - 3.029 2.985 -0.144
ENSG00000123136 E037 22.538914 2.037179e-03 5.127683e-10 8.008444e-09 19 14412679 14412711 33 - 1.608 1.138 -1.637
ENSG00000123136 E038 29.626801 9.410571e-03 2.033575e-15 7.374709e-14 19 14412712 14412814 103 - 1.799 1.173 -2.156
ENSG00000123136 E039 33.283112 2.031844e-02 3.697091e-10 5.928583e-09 19 14412815 14413012 198 - 1.825 1.243 -1.995
ENSG00000123136 E040 1777.855845 1.688866e-03 2.433429e-01 3.780960e-01 19 14413013 14413224 212 - 3.193 3.161 -0.107
ENSG00000123136 E041 6.610400 2.568569e-03 2.902325e-01 4.310112e-01 19 14413980 14414014 35 - 0.916 0.774 -0.553
ENSG00000123136 E042 4.314638 3.697884e-03 6.843851e-02 1.407898e-01 19 14414888 14414934 47 - 0.853 0.585 -1.106
ENSG00000123136 E043 5.345491 4.206342e-02 1.961073e-01 3.213501e-01 19 14415948 14415988 41 - 0.886 0.667 -0.876
ENSG00000123136 E044 9.078359 5.577102e-02 1.123331e-02 3.172411e-02 19 14416269 14416405 137 - 1.190 0.807 -1.420
ENSG00000123136 E045 5.669263 1.136850e-01 2.499082e-02 6.185488e-02 19 14418929 14419093 165 - 1.043 0.613 -1.695
ENSG00000123136 E046 769.624281 2.322359e-03 7.058993e-01 8.041715e-01 19 14419270 14419383 114 - 2.819 2.801 -0.059