ENSG00000123124

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265428 ENSG00000123124 HEK293_OSMI2_2hA HEK293_TMG_2hB WWP1 protein_coding protein_coding 9.207456 2.22275 15.08732 0.1614517 0.5447765 2.757399 3.0290623 1.5959814 4.179576 0.18643971 0.5705906 1.383349 0.44643333 0.7335000 0.27996667 -0.45353333 1.066274e-02 9.186665e-08 FALSE TRUE
ENST00000517970 ENSG00000123124 HEK293_OSMI2_2hA HEK293_TMG_2hB WWP1 protein_coding protein_coding 9.207456 2.22275 15.08732 0.1614517 0.5447765 2.757399 0.9434390 0.0000000 2.106821 0.00000000 0.7170375 7.725755 0.06635000 0.0000000 0.14043333 0.14043333 2.050641e-04 9.186665e-08 FALSE TRUE
ENST00000521079 ENSG00000123124 HEK293_OSMI2_2hA HEK293_TMG_2hB WWP1 protein_coding processed_transcript 9.207456 2.22275 15.08732 0.1614517 0.5447765 2.757399 0.6723949 0.0000000 1.745204 0.00000000 0.1208686 7.455495 0.04092917 0.0000000 0.11566667 0.11566667 9.186665e-08 9.186665e-08 FALSE FALSE
ENST00000521997 ENSG00000123124 HEK293_OSMI2_2hA HEK293_TMG_2hB WWP1 protein_coding retained_intron 9.207456 2.22275 15.08732 0.1614517 0.5447765 2.757399 2.0635233 0.2749738 3.214927 0.27497382 0.9419344 3.500365 0.18393750 0.1089000 0.20923333 0.10033333 3.484453e-01 9.186665e-08 FALSE FALSE
MSTRG.31767.2 ENSG00000123124 HEK293_OSMI2_2hA HEK293_TMG_2hB WWP1 protein_coding   9.207456 2.22275 15.08732 0.1614517 0.5447765 2.757399 0.7473399 0.0000000 1.460171 0.00000000 0.3664908 7.199840 0.10592500 0.0000000 0.09576667 0.09576667 1.396802e-04 9.186665e-08 FALSE TRUE
MSTRG.31767.4 ENSG00000123124 HEK293_OSMI2_2hA HEK293_TMG_2hB WWP1 protein_coding   9.207456 2.22275 15.08732 0.1614517 0.5447765 2.757399 0.5954457 0.2674602 1.043973 0.01065365 0.4371892 1.925486 0.05609583 0.1209333 0.06846667 -0.05246667 5.165953e-01 9.186665e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000123124 E001 1.7692921 0.0603020093 8.834320e-02 1.725913e-01 8 86342547 86342736 190 + 0.430 0.000 -13.109
ENSG00000123124 E002 4.1574451 0.0132751545 3.181453e-03 1.080141e-02 8 86342737 86342773 37 + 0.695 0.000 -14.320
ENSG00000123124 E003 4.1574451 0.0132751545 3.181453e-03 1.080141e-02 8 86342774 86342775 2 + 0.695 0.000 -14.320
ENSG00000123124 E004 16.8269593 0.0081136478 5.334584e-07 4.693141e-06 8 86342776 86342930 155 + 1.225 0.398 -3.395
ENSG00000123124 E005 20.4329816 0.0010878215 4.064560e-05 2.338565e-04 8 86368939 86369031 93 + 1.286 0.796 -1.803
ENSG00000123124 E006 17.6423976 0.0010219550 1.318890e-04 6.671110e-04 8 86374030 86374040 11 + 1.225 0.741 -1.810
ENSG00000123124 E007 33.2158738 0.0006120573 6.827356e-04 2.835830e-03 8 86374041 86374120 80 + 1.465 1.184 -0.983
ENSG00000123124 E008 38.3467485 0.0907909220 7.740154e-02 1.552964e-01 8 86380726 86380816 91 + 1.520 1.284 -0.817
ENSG00000123124 E009 28.4534707 0.0941282208 2.023277e-01 3.291342e-01 8 86380817 86380864 48 + 1.384 1.228 -0.546
ENSG00000123124 E010 44.5651347 0.0009562456 3.901470e-03 1.286705e-02 8 86381505 86381629 125 + 1.579 1.385 -0.666
ENSG00000123124 E011 0.4741261 0.0221854003 4.506447e-01 5.917245e-01 8 86386836 86387026 191 + 0.108 0.243 1.413
ENSG00000123124 E012 39.9337012 0.0018385820 1.192736e-01 2.189050e-01 8 86398342 86398479 138 + 1.520 1.424 -0.332
ENSG00000123124 E013 20.7854213 0.0038146160 4.049382e-01 5.486164e-01 8 86398572 86398574 3 + 1.246 1.184 -0.222
ENSG00000123124 E014 34.7756337 0.0006292877 5.090202e-01 6.443773e-01 8 86398575 86398638 64 + 1.431 1.502 0.247
ENSG00000123124 E015 63.5972356 0.0006459456 5.576439e-01 6.860132e-01 8 86402019 86402203 185 + 1.701 1.691 -0.034
ENSG00000123124 E016 0.0000000       8 86405055 86405120 66 +      
ENSG00000123124 E017 86.0775541 0.0004213708 1.056374e-03 4.154535e-03 8 86411538 86411874 337 + 1.853 1.704 -0.502
ENSG00000123124 E018 0.2987644 0.0294904124 1.000000e+00   8 86417223 86417279 57 + 0.108 0.000 -10.512
ENSG00000123124 E019 40.9289624 0.0005155893 2.123079e-03 7.605532e-03 8 86425223 86425318 96 + 1.546 1.328 -0.751
ENSG00000123124 E020 59.3923005 0.0004331961 7.309521e-03 2.202342e-02 8 86427643 86427817 175 + 1.696 1.551 -0.494
ENSG00000123124 E021 38.4143873 0.0005284502 8.182919e-02 1.624297e-01 8 86430697 86430751 55 + 1.507 1.398 -0.375
ENSG00000123124 E022 48.6587435 0.0005017155 2.068099e-03 7.435573e-03 8 86431406 86431490 85 + 1.619 1.424 -0.670
ENSG00000123124 E023 58.0273050 0.0004174961 8.792292e-03 2.576447e-02 8 86431615 86431743 129 + 1.685 1.542 -0.488
ENSG00000123124 E024 27.1584946 0.0007555013 2.708683e-01 4.095222e-01 8 86435452 86435457 6 + 1.354 1.279 -0.259
ENSG00000123124 E025 47.1814320 0.0005950738 2.620591e-01 3.997803e-01 8 86435458 86435527 70 + 1.584 1.532 -0.178
ENSG00000123124 E026 0.0000000       8 86435611 86435632 22 +      
ENSG00000123124 E027 45.2065007 0.0005091836 4.230915e-01 5.662152e-01 8 86435633 86435704 72 + 1.563 1.532 -0.105
ENSG00000123124 E028 53.3255887 0.0004833085 4.072581e-01 5.508431e-01 8 86438585 86438673 89 + 1.631 1.603 -0.096
ENSG00000123124 E029 0.2944980 0.3526779228 1.000000e+00   8 86440626 86440733 108 + 0.108 0.000 -10.511
ENSG00000123124 E030 0.7427016 0.0157448677 4.048059e-01 5.484974e-01 8 86442272 86442618 347 + 0.232 0.000 -11.834
ENSG00000123124 E031 59.8998539 0.0005457307 8.138762e-01 8.820329e-01 8 86442619 86442778 160 + 1.667 1.704 0.127
ENSG00000123124 E032 56.7532170 0.0012948877 3.122282e-01 4.547603e-01 8 86448148 86448281 134 + 1.634 1.717 0.283
ENSG00000123124 E033 0.0000000       8 86448282 86448372 91 +      
ENSG00000123124 E034 69.6114453 0.0004015744 2.717250e-02 6.634552e-02 8 86448373 86448513 141 + 1.709 1.846 0.461
ENSG00000123124 E035 68.9977829 0.0026667551 2.259629e-01 3.575468e-01 8 86452559 86452679 121 + 1.719 1.811 0.313
ENSG00000123124 E036 52.8077169 0.0004914924 2.149821e-02 5.463997e-02 8 86457921 86457988 68 + 1.590 1.747 0.531
ENSG00000123124 E037 38.9001288 0.0010502665 2.217071e-02 5.602933e-02 8 86457989 86458025 37 + 1.457 1.634 0.605
ENSG00000123124 E038 29.7374401 0.0007003975 2.425559e-02 6.033943e-02 8 86461224 86461226 3 + 1.340 1.532 0.662
ENSG00000123124 E039 56.1830035 0.0017223907 3.140657e-03 1.067914e-02 8 86461227 86461320 94 + 1.607 1.801 0.657
ENSG00000123124 E040 0.7500885 0.1450386354 8.445722e-01 9.032549e-01 8 86461321 86461742 422 + 0.195 0.242 0.397
ENSG00000123124 E041 46.9522188 0.0010306460 3.206606e-04 1.463424e-03 8 86461774 86461846 73 + 1.519 1.758 0.814
ENSG00000123124 E042 167.5139597 0.0139971746 6.839340e-08 7.173185e-07 8 86466794 86468670 1877 + 2.029 2.378 1.169
ENSG00000123124 E043 0.1482932 0.0413413194 7.846321e-02   8 86478075 86478420 346 + 0.000 0.243 14.059