ENSG00000122970

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000242591 ENSG00000122970 HEK293_OSMI2_2hA HEK293_TMG_2hB IFT81 protein_coding protein_coding 7.382182 2.897968 11.32594 0.09605703 0.67673 1.962821 2.8395312 0.6600965 4.842020 0.35301323 0.42552218 2.85614464 0.35414583 0.2307667 0.42643333 0.19566667 0.60642887 0.02637369 FALSE  
ENST00000361948 ENSG00000122970 HEK293_OSMI2_2hA HEK293_TMG_2hB IFT81 protein_coding protein_coding 7.382182 2.897968 11.32594 0.09605703 0.67673 1.962821 0.2533738 0.2163351 0.204738 0.07630272 0.02231547 -0.07588269 0.04712083 0.0733000 0.01843333 -0.05486667 0.02637369 0.02637369 FALSE  
ENST00000552912 ENSG00000122970 HEK293_OSMI2_2hA HEK293_TMG_2hB IFT81 protein_coding protein_coding 7.382182 2.897968 11.32594 0.09605703 0.67673 1.962821 3.6465183 1.8193823 5.614443 0.38196994 0.22570842 1.62035370 0.50125833 0.6235333 0.49773333 -0.12580000 0.63375829 0.02637369 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122970 E001 0.5975289 0.0449262442 4.236755e-01 5.667339e-01 12 110124335 110124356 22 + 0.215 0.000 -10.601
ENSG00000122970 E002 6.2107598 0.0027028412 9.766011e-01 9.893805e-01 12 110124357 110124391 35 + 0.786 0.799 0.051
ENSG00000122970 E003 15.3442678 0.0013271076 1.307515e-01 2.351992e-01 12 110124392 110124443 52 + 1.169 1.012 -0.568
ENSG00000122970 E004 33.9177297 0.0007409277 9.638488e-02 1.849413e-01 12 110124444 110124861 418 + 1.488 1.372 -0.400
ENSG00000122970 E005 39.4769847 0.0006396905 4.185215e-03 1.366416e-02 12 110127360 110127472 113 + 1.570 1.372 -0.682
ENSG00000122970 E006 38.0062100 0.0005778896 8.398788e-05 4.469578e-04 12 110127473 110127524 52 + 1.570 1.276 -1.015
ENSG00000122970 E007 49.5573653 0.0005480824 2.503269e-05 1.517519e-04 12 110128046 110128149 104 + 1.680 1.407 -0.935
ENSG00000122970 E008 56.9258302 0.0052419182 9.139864e-02 1.773135e-01 12 110128950 110129130 181 + 1.709 1.603 -0.359
ENSG00000122970 E009 33.6900282 0.0006390360 1.456268e-01 2.557054e-01 12 110132547 110132592 46 + 1.483 1.384 -0.343
ENSG00000122970 E010 34.5768067 0.0006357868 4.417378e-01 5.833819e-01 12 110132593 110132636 44 + 1.485 1.439 -0.158
ENSG00000122970 E011 38.2683168 0.0033483306 3.371058e-01 4.809635e-01 12 110134948 110135013 66 + 1.533 1.470 -0.216
ENSG00000122970 E012 45.0674156 0.0008987277 8.834358e-01 9.294297e-01 12 110135327 110135437 111 + 1.588 1.588 0.001
ENSG00000122970 E013 22.4176900 0.0034062870 3.959238e-01 5.397181e-01 12 110136776 110136806 31 + 1.277 1.359 0.288
ENSG00000122970 E014 23.6404802 0.0015992803 3.295049e-01 4.730252e-01 12 110136807 110136860 54 + 1.295 1.384 0.310
ENSG00000122970 E015 34.7735784 0.0007654199 6.325877e-01 7.474093e-01 12 110143382 110143545 164 + 1.464 1.507 0.147
ENSG00000122970 E016 41.6128644 0.0160779859 9.353927e-01 9.633347e-01 12 110146953 110147048 96 + 1.545 1.564 0.065
ENSG00000122970 E017 0.2987644 0.0296932749 1.000000e+00   12 110162358 110162479 122 + 0.121 0.000 -9.594
ENSG00000122970 E018 61.7015618 0.0023801566 9.786954e-01 9.907763e-01 12 110162919 110163065 147 + 1.715 1.723 0.028
ENSG00000122970 E019 9.3575521 0.0479928250 3.981448e-06 2.898153e-05 12 110167871 110169182 1312 + 0.670 1.359 2.571
ENSG00000122970 E020 0.0000000       12 110171895 110172086 192 +      
ENSG00000122970 E021 71.0316862 0.0004201988 6.357703e-02 1.326513e-01 12 110180422 110180571 150 + 1.796 1.711 -0.289
ENSG00000122970 E022 63.7210004 0.0004242145 5.271884e-01 6.603214e-01 12 110190920 110191048 129 + 1.739 1.716 -0.079
ENSG00000122970 E023 0.2966881 0.0274424043 1.000000e+00   12 110191049 110191061 13 + 0.120 0.000 -9.594
ENSG00000122970 E024 42.9106182 0.0029689344 1.173510e-01 2.161637e-01 12 110192617 110192706 90 + 1.588 1.489 -0.340
ENSG00000122970 E025 0.3729606 0.0279675302 3.078552e-01 4.500902e-01 12 110203335 110203863 529 + 0.064 0.221 2.054
ENSG00000122970 E026 50.2025281 0.0007628925 9.583288e-01 9.778974e-01 12 110203864 110203950 87 + 1.631 1.644 0.045
ENSG00000122970 E027 0.6717251 0.0279221892 7.943844e-01 8.686307e-01 12 110203951 110205442 1492 + 0.170 0.221 0.468
ENSG00000122970 E028 42.3288494 0.0005575343 2.619127e-01 3.996406e-01 12 110205443 110205514 72 + 1.545 1.624 0.270
ENSG00000122970 E029 49.6371642 0.0005059434 3.713516e-01 5.157844e-01 12 110205595 110205680 86 + 1.614 1.675 0.209
ENSG00000122970 E030 42.0935854 0.0005573559 6.555589e-01 7.654274e-01 12 110209171 110209216 46 + 1.551 1.588 0.129
ENSG00000122970 E031 0.0000000       12 110216537 110216605 69 +      
ENSG00000122970 E032 0.1482932 0.0411683006 1.058238e-01   12 110216708 110216833 126 + 0.000 0.220 12.418
ENSG00000122970 E033 117.6955344 0.0022983992 1.527405e-14 4.904446e-13 12 110218044 110218793 750 + 1.907 2.216 1.034