ENSG00000122952

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361148 ENSG00000122952 HEK293_OSMI2_2hA HEK293_TMG_2hB ZWINT protein_coding protein_coding 154.2144 162.5141 153.7176 21.23253 2.233087 -0.08027794 18.82642 16.236731 22.45958 0.8604375 2.525073 0.4678236 0.1233833 0.10246667 0.1458333 0.04336667 2.076196e-01 1.081075e-06 FALSE TRUE
ENST00000373944 ENSG00000122952 HEK293_OSMI2_2hA HEK293_TMG_2hB ZWINT protein_coding protein_coding 154.2144 162.5141 153.7176 21.23253 2.233087 -0.08027794 41.90907 69.621476 38.84448 10.0242760 3.558172 -0.8416585 0.2727708 0.42680000 0.2526333 -0.17416667 1.264001e-04 1.081075e-06 FALSE TRUE
ENST00000395405 ENSG00000122952 HEK293_OSMI2_2hA HEK293_TMG_2hB ZWINT protein_coding protein_coding 154.2144 162.5141 153.7176 21.23253 2.233087 -0.08027794 47.14687 47.955191 39.62370 8.0309216 1.806153 -0.2752602 0.3048167 0.29246667 0.2582333 -0.03423333 4.846253e-01 1.081075e-06 FALSE TRUE
ENST00000460654 ENSG00000122952 HEK293_OSMI2_2hA HEK293_TMG_2hB ZWINT protein_coding processed_transcript 154.2144 162.5141 153.7176 21.23253 2.233087 -0.08027794 22.44468 16.235726 28.74274 2.9802908 2.072800 0.8236394 0.1445583 0.09870000 0.1866667 0.08796667 1.081075e-06 1.081075e-06 TRUE TRUE
ENST00000494312 ENSG00000122952 HEK293_OSMI2_2hA HEK293_TMG_2hB ZWINT protein_coding retained_intron 154.2144 162.5141 153.7176 21.23253 2.233087 -0.08027794 19.52893 7.708944 19.86663 1.5730413 1.699000 1.3645980 0.1267583 0.05043333 0.1292000 0.07876667 1.903663e-02 1.081075e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122952 E001 52.81915 1.005718e-03 4.261693e-02 9.584559e-02 10 56357227 56357437 211 - 1.654 1.771 0.395
ENSG00000122952 E002 49.08628 6.482439e-03 1.420483e-02 3.868879e-02 10 56357438 56357444 7 - 1.583 1.754 0.580
ENSG00000122952 E003 69.02403 1.433419e-02 4.143407e-03 1.354447e-02 10 56357445 56357478 34 - 1.689 1.912 0.753
ENSG00000122952 E004 1382.64244 5.105556e-03 3.836261e-04 1.711291e-03 10 56357479 56357815 337 - 3.048 3.173 0.418
ENSG00000122952 E005 2189.39464 1.171398e-03 3.275047e-01 4.709746e-01 10 56357816 56358142 327 - 3.317 3.338 0.071
ENSG00000122952 E006 819.59369 1.249085e-04 1.690210e-02 4.471827e-02 10 56358143 56358185 43 - 2.922 2.902 -0.065
ENSG00000122952 E007 114.73204 3.275831e-03 1.544812e-01 2.677318e-01 10 56358186 56358186 1 - 2.088 2.042 -0.152
ENSG00000122952 E008 285.58998 7.973100e-04 2.748204e-01 4.140402e-01 10 56358187 56358376 190 - 2.428 2.468 0.132
ENSG00000122952 E009 942.99523 9.721268e-05 4.239391e-02 9.543467e-02 10 56358377 56358459 83 - 2.947 2.983 0.120
ENSG00000122952 E010 914.73345 3.466469e-04 6.987507e-02 1.431667e-01 10 56358556 56358630 75 - 2.933 2.967 0.114
ENSG00000122952 E011 737.84427 8.549561e-04 6.557636e-04 2.736820e-03 10 56358631 56358687 57 - 2.816 2.885 0.230
ENSG00000122952 E012 490.71150 1.074847e-03 1.212894e-04 6.198689e-04 10 56358688 56358724 37 - 2.624 2.715 0.305
ENSG00000122952 E013 1024.23477 5.102703e-04 7.053386e-01 8.037268e-01 10 56358805 56358908 104 - 2.995 3.007 0.040
ENSG00000122952 E014 837.36114 3.683102e-04 1.449511e-04 7.252610e-04 10 56358909 56358947 39 - 2.945 2.897 -0.161
ENSG00000122952 E015 935.53169 1.127380e-04 3.546932e-06 2.612377e-05 10 56359476 56359532 57 - 2.994 2.949 -0.150
ENSG00000122952 E016 1582.20706 7.499488e-05 4.292574e-05 2.456992e-04 10 56359687 56359853 167 - 3.211 3.184 -0.088
ENSG00000122952 E017 112.27849 2.706827e-02 5.279531e-07 4.648593e-06 10 56359854 56360017 164 - 2.262 1.814 -1.501
ENSG00000122952 E018 1218.77874 1.633499e-04 2.776730e-02 6.755402e-02 10 56360018 56360141 124 - 3.090 3.075 -0.048
ENSG00000122952 E019 50.59240 2.068010e-02 1.744396e-07 1.691713e-06 10 56360142 56360179 38 - 1.922 1.468 -1.540
ENSG00000122952 E020 97.89099 2.942334e-02 1.581007e-06 1.257102e-05 10 56360180 56360292 113 - 2.201 1.758 -1.487
ENSG00000122952 E021 547.20933 1.284431e-04 1.767505e-01 2.970147e-01 10 56360293 56360295 3 - 2.740 2.731 -0.031
ENSG00000122952 E022 951.22900 2.906806e-04 6.896866e-01 7.915324e-01 10 56360296 56360383 88 - 2.970 2.973 0.009
ENSG00000122952 E023 614.98342 5.584722e-04 2.525097e-01 3.888666e-01 10 56361196 56361312 117 - 2.790 2.776 -0.047