ENSG00000122786

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361675 ENSG00000122786 HEK293_OSMI2_2hA HEK293_TMG_2hB CALD1 protein_coding protein_coding 20.2661 9.127378 34.21287 0.5212535 0.4252585 1.905109 1.4736559 0.5776582 2.63406415 0.1480193 0.36091590 2.169708 0.07683333 0.06556667 0.077266667 0.01170000 8.363540e-01 9.960979e-05 FALSE TRUE
ENST00000393118 ENSG00000122786 HEK293_OSMI2_2hA HEK293_TMG_2hB CALD1 protein_coding protein_coding 20.2661 9.127378 34.21287 0.5212535 0.4252585 1.905109 4.4901546 0.6429737 8.94288866 0.3263583 0.37475824 3.777257 0.17236667 0.06700000 0.261333333 0.19433333 2.194618e-01 9.960979e-05 FALSE TRUE
ENST00000424922 ENSG00000122786 HEK293_OSMI2_2hA HEK293_TMG_2hB CALD1 protein_coding protein_coding 20.2661 9.127378 34.21287 0.5212535 0.4252585 1.905109 6.9463938 2.6123122 11.31317935 0.5541577 1.16094004 2.110368 0.35511250 0.28520000 0.331366667 0.04616667 7.965094e-01 9.960979e-05 FALSE TRUE
ENST00000480638 ENSG00000122786 HEK293_OSMI2_2hA HEK293_TMG_2hB CALD1 protein_coding retained_intron 20.2661 9.127378 34.21287 0.5212535 0.4252585 1.905109 0.8746591 2.5148158 0.08854436 0.7209991 0.08854436 -4.679261 0.09713333 0.27516667 0.002666667 -0.27250000 9.960979e-05 9.960979e-05   FALSE
MSTRG.30732.16 ENSG00000122786 HEK293_OSMI2_2hA HEK293_TMG_2hB CALD1 protein_coding   20.2661 9.127378 34.21287 0.5212535 0.4252585 1.905109 4.1129878 2.1134746 7.48734867 0.5511118 0.49920449 1.819954 0.19968750 0.23353333 0.218633333 -0.01490000 1.000000e+00 9.960979e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122786 E001 0.0000000       7 134744252 134744363 112 +      
ENSG00000122786 E002 0.0000000       7 134745467 134745572 106 +      
ENSG00000122786 E003 0.2924217 0.0290785164 1.000000e+00   7 134779420 134779624 205 + 0.108 0.000 -13.680
ENSG00000122786 E004 0.0000000       7 134779625 134779633 9 +      
ENSG00000122786 E005 0.0000000       7 134779634 134779636 3 +      
ENSG00000122786 E006 0.1472490 0.0424392199 1.000000e+00   7 134779637 134779638 2 + 0.058 0.000 -12.667
ENSG00000122786 E007 0.5911862 0.0184176196 4.365622e-01 5.786392e-01 7 134779639 134779649 11 + 0.195 0.000 -14.667
ENSG00000122786 E008 7.5193784 0.0021762515 1.942148e-01 3.190522e-01 7 134779650 134779677 28 + 0.851 0.739 -0.446
ENSG00000122786 E009 9.9165140 0.0016822717 2.559516e-01 3.929088e-01 7 134779678 134779714 37 + 0.952 0.887 -0.242
ENSG00000122786 E010 11.8760433 0.0014589533 1.348573e-01 2.409036e-01 7 134779715 134779749 35 + 1.027 0.928 -0.370
ENSG00000122786 E011 0.0000000       7 134809591 134809627 37 +      
ENSG00000122786 E012 0.0000000       7 134821985 134822061 77 +      
ENSG00000122786 E013 14.5711643 0.0013685665 8.063926e-02 1.605539e-01 7 134843884 134843971 88 + 1.111 0.998 -0.413
ENSG00000122786 E014 0.0000000       7 134844251 134844336 86 +      
ENSG00000122786 E015 0.0000000       7 134866841 134867039 199 +      
ENSG00000122786 E016 17.1375093 0.0010041032 1.338354e-02 3.680946e-02 7 134867693 134867804 112 + 1.186 0.998 -0.678
ENSG00000122786 E017 0.0000000       7 134867805 134868241 437 +      
ENSG00000122786 E018 1.5499206 0.1570924603 8.963613e-01 9.377476e-01 7 134891400 134891424 25 + 0.329 0.397 0.399
ENSG00000122786 E019 10.0742439 0.0018051646 4.232450e-01 5.663365e-01 7 134891425 134891457 33 + 0.945 0.928 -0.064
ENSG00000122786 E020 82.2878678 0.0012647913 1.627994e-04 8.039480e-04 7 134891458 134891609 152 + 1.830 1.721 -0.368
ENSG00000122786 E021 84.3492530 0.0003417372 8.600542e-04 3.473643e-03 7 134891610 134891673 64 + 1.834 1.762 -0.245
ENSG00000122786 E022 0.6997360 0.0168073829 5.730282e-04 2.432847e-03 7 134899832 134900053 222 + 0.000 0.600 19.182
ENSG00000122786 E023 0.0000000       7 134920566 134920720 155 +      
ENSG00000122786 E024 0.1472490 0.0424392199 1.000000e+00   7 134928049 134928090 42 + 0.058 0.000 -12.667
ENSG00000122786 E025 122.9600377 0.0025430058 1.209719e-04 6.184463e-04 7 134928754 134928877 124 + 1.999 1.909 -0.300
ENSG00000122786 E026 67.1463177 0.0022318243 6.707132e-03 2.046299e-02 7 134928878 134928900 23 + 1.736 1.669 -0.230
ENSG00000122786 E027 194.4529432 0.0003342468 1.646481e-08 1.949871e-07 7 134932988 134933193 206 + 2.198 2.102 -0.320
ENSG00000122786 E028 232.0964677 0.0002010541 8.030514e-06 5.451524e-05 7 134933194 134933390 197 + 2.264 2.228 -0.121
ENSG00000122786 E029 34.3142188 0.0333113304 2.466267e-01 3.819960e-01 7 134933391 134934077 687 + 1.394 1.614 0.755
ENSG00000122786 E030 21.0145184 0.0008966065 2.215627e-01 3.522760e-01 7 134935688 134935765 78 + 1.246 1.222 -0.083
ENSG00000122786 E031 100.7071053 0.0013350345 4.403412e-03 1.427421e-02 7 134941092 134941140 49 + 1.907 1.866 -0.138
ENSG00000122786 E032 90.5946446 0.0002819851 5.260097e-06 3.724852e-05 7 134941141 134941181 41 + 1.876 1.744 -0.446
ENSG00000122786 E033 108.5919615 0.0002963101 9.494971e-07 7.913343e-06 7 134941182 134941237 56 + 1.953 1.824 -0.433
ENSG00000122786 E034 0.0000000       7 134944456 134944551 96 +      
ENSG00000122786 E035 223.1966723 0.0002126290 9.213298e-07 7.705420e-06 7 134947508 134947769 262 + 2.250 2.196 -0.181
ENSG00000122786 E036 0.6213751 0.0212513552 7.680289e-01 8.501121e-01 7 134947770 134948102 333 + 0.154 0.242 0.811
ENSG00000122786 E037 76.7472321 0.0003756597 4.791554e-01 6.175434e-01 7 134950374 134950374 1 + 1.768 1.829 0.206
ENSG00000122786 E038 175.6632382 0.0059799970 4.720147e-01 6.110984e-01 7 134950375 134950514 140 + 2.124 2.191 0.223
ENSG00000122786 E039 114.3253685 0.0009775113 9.968119e-01 1.000000e+00 7 134958069 134958112 44 + 1.933 2.030 0.325
ENSG00000122786 E040 65.9540381 0.0003503077 4.226610e-01 5.657908e-01 7 134958209 134958211 3 + 1.708 1.761 0.179
ENSG00000122786 E041 117.4810338 0.0002611084 9.876779e-01 9.963822e-01 7 134958212 134958290 79 + 1.945 2.041 0.323
ENSG00000122786 E042 136.2924050 0.0002322997 6.610009e-01 7.695622e-01 7 134959974 134960111 138 + 2.004 2.117 0.379
ENSG00000122786 E043 0.4847352 0.2208710352 5.536068e-01 6.827092e-01 7 134960112 134960530 419 + 0.109 0.243 1.394
ENSG00000122786 E044 0.1482932 0.0417573197 1.008899e-01   7 134960531 134960532 2 + 0.000 0.242 17.179
ENSG00000122786 E045 111.3081639 0.0003192112 3.375517e-01 4.814394e-01 7 134960533 134960628 96 + 1.928 1.985 0.191
ENSG00000122786 E046 1.6554517 0.0168411444 4.226825e-01 5.658156e-01 7 134960629 134962389 1761 + 0.300 0.511 1.177
ENSG00000122786 E047 0.4031496 0.0242313767 1.830977e-02 4.780962e-02 7 134962820 134962934 115 + 0.000 0.397 18.185
ENSG00000122786 E048 0.3030308 0.3651999688 1.000000e+00   7 134965211 134965305 95 + 0.109 0.000 -13.674
ENSG00000122786 E049 120.5107251 0.0008380945 7.422028e-02 1.502866e-01 7 134965306 134965386 81 + 1.970 1.992 0.073
ENSG00000122786 E050 0.4804688 0.0222300980 5.428687e-01 6.735663e-01 7 134965387 134965437 51 + 0.109 0.242 1.395
ENSG00000122786 E051 169.4606756 0.0001912947 1.138577e-02 3.208675e-02 7 134968340 134968553 214 + 2.121 2.132 0.035
ENSG00000122786 E052 1044.7226298 0.0143033374 7.086656e-07 6.077892e-06 7 134968554 134970729 2176 + 2.835 3.143 1.026