ENSG00000122783

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393114 ENSG00000122783 HEK293_OSMI2_2hA HEK293_TMG_2hB CYREN protein_coding protein_coding 60.56847 72.58425 55.05983 5.642043 0.2486081 -0.3985929 19.553280 24.912944 18.326798 2.1821137 0.7054103 -0.4427327 0.32341667 0.34410000 0.33283333 -0.011266667 0.91197378 1.261356e-05 FALSE TRUE
ENST00000424142 ENSG00000122783 HEK293_OSMI2_2hA HEK293_TMG_2hB CYREN protein_coding protein_coding 60.56847 72.58425 55.05983 5.642043 0.2486081 -0.3985929 19.385967 26.616151 15.470759 2.0788076 0.9285489 -0.7823677 0.31435000 0.36680000 0.28106667 -0.085733333 0.01935229 1.261356e-05 FALSE FALSE
ENST00000487774 ENSG00000122783 HEK293_OSMI2_2hA HEK293_TMG_2hB CYREN protein_coding retained_intron 60.56847 72.58425 55.05983 5.642043 0.2486081 -0.3985929 3.749678 2.572754 2.959332 0.1946953 0.1072191 0.2012282 0.06407917 0.03556667 0.05373333 0.018166667 0.01414693 1.261356e-05   FALSE
ENST00000617987 ENSG00000122783 HEK293_OSMI2_2hA HEK293_TMG_2hB CYREN protein_coding protein_coding 60.56847 72.58425 55.05983 5.642043 0.2486081 -0.3985929 3.984535 4.813144 3.552159 0.3449182 0.6904191 -0.4372218 0.06557500 0.06720000 0.06453333 -0.002666667 0.95068445 1.261356e-05 FALSE FALSE
MSTRG.30736.8 ENSG00000122783 HEK293_OSMI2_2hA HEK293_TMG_2hB CYREN protein_coding   60.56847 72.58425 55.05983 5.642043 0.2486081 -0.3985929 5.033847 3.726214 6.910117 1.8834483 1.1583813 0.8892193 0.08535000 0.04760000 0.12533333 0.077733333 0.58054191 1.261356e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122783 E001 6.4729053 0.0024714017 2.425543e-08 2.782054e-07 7 135092363 135093378 1016 - 1.173 0.496 -2.705
ENSG00000122783 E002 21.6454483 0.0058932952 1.322729e-12 3.180442e-11 7 135093379 135094582 1204 - 1.618 1.055 -1.967
ENSG00000122783 E003 0.5503986 0.0226893182 8.379749e-01 8.987055e-01 7 135147977 135148163 187 - 0.145 0.186 0.427
ENSG00000122783 E004 45.0181457 0.0005253622 2.408568e-13 6.487929e-12 7 135165782 135165784 3 - 1.843 1.478 -1.241
ENSG00000122783 E005 107.3192221 0.0003160467 1.978528e-05 1.228334e-04 7 135165785 135165828 44 - 2.102 1.972 -0.437
ENSG00000122783 E006 991.3662795 0.0027565920 3.522983e-02 8.208522e-02 7 135165829 135166343 515 - 2.938 3.001 0.212
ENSG00000122783 E007 484.8590841 0.0001420301 1.984581e-02 5.116182e-02 7 135166344 135166467 124 - 2.636 2.691 0.182
ENSG00000122783 E008 398.9689799 0.0002274455 9.922847e-05 5.182229e-04 7 135166468 135166574 107 - 2.527 2.616 0.298
ENSG00000122783 E009 247.1160774 0.0036118720 3.057163e-03 1.043456e-02 7 135166575 135166599 25 - 2.296 2.415 0.398
ENSG00000122783 E010 663.7381146 0.0014057265 3.617520e-02 8.392358e-02 7 135166600 135166871 272 - 2.769 2.825 0.187
ENSG00000122783 E011 6.7158191 0.0024577983 5.821760e-01 7.065892e-01 7 135167363 135167408 46 - 0.817 0.899 0.318
ENSG00000122783 E012 363.7051114 0.0001553855 4.208523e-01 5.640272e-01 7 135167732 135167807 76 - 2.548 2.549 0.003
ENSG00000122783 E013 27.8789792 0.0052934630 3.030211e-01 4.449388e-01 7 135167808 135168179 372 - 1.483 1.420 -0.216
ENSG00000122783 E014 23.5930073 0.0007717468 2.812993e-01 4.211953e-01 7 135168304 135168595 292 - 1.415 1.354 -0.212
ENSG00000122783 E015 17.2732268 0.0010838698 3.927564e-01 5.366578e-01 7 135168596 135168744 149 - 1.285 1.230 -0.192
ENSG00000122783 E016 7.7530584 0.0021856732 5.307952e-01 6.633260e-01 7 135168745 135168748 4 - 0.970 0.914 -0.213
ENSG00000122783 E017 203.2957977 0.0009060764 4.813803e-01 6.196057e-01 7 135168749 135168785 37 - 2.273 2.310 0.122
ENSG00000122783 E018 460.6413506 0.0001784211 1.015093e-02 2.913645e-02 7 135168786 135168930 145 - 2.668 2.641 -0.092
ENSG00000122783 E019 287.9814441 0.0001573339 9.723876e-05 5.090947e-04 7 135168931 135168968 38 - 2.488 2.422 -0.221
ENSG00000122783 E020 406.3911118 0.0007128107 2.077842e-04 9.972330e-04 7 135168969 135169060 92 - 2.634 2.570 -0.211
ENSG00000122783 E021 6.3689860 0.0030456419 3.919813e-01 5.359272e-01 7 135169422 135169474 53 - 0.911 0.819 -0.352
ENSG00000122783 E022 28.0608560 0.0235853824 3.512278e-01 4.954406e-01 7 135170276 135170398 123 - 1.499 1.410 -0.305
ENSG00000122783 E023 214.4836053 0.0087155569 2.465633e-01 3.819197e-01 7 135170399 135170651 253 - 2.269 2.338 0.229
ENSG00000122783 E024 214.4782055 0.0003522588 2.274413e-04 1.081039e-03 7 135170652 135170795 144 - 2.366 2.288 -0.260