ENSG00000122779

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343526 ENSG00000122779 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM24 protein_coding protein_coding 16.25983 7.125058 24.41905 0.9101169 0.1395932 1.775601 7.1398823 3.4724859 10.3469282 0.8121340 0.22660791 1.572407 0.47137500 0.4727000 0.423800000 -0.04890000 0.780263390 0.002109559 FALSE TRUE
ENST00000415680 ENSG00000122779 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM24 protein_coding protein_coding 16.25983 7.125058 24.41905 0.9101169 0.1395932 1.775601 0.1035589 0.7154713 0.0000000 0.4277905 0.00000000 -6.180847 0.01885000 0.1210000 0.000000000 -0.12100000 0.086644653 0.002109559 FALSE TRUE
MSTRG.30778.3 ENSG00000122779 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM24 protein_coding   16.25983 7.125058 24.41905 0.9101169 0.1395932 1.775601 0.3423232 0.9618623 0.1150982 0.2955840 0.09187415 -2.957691 0.03832083 0.1445333 0.004700000 -0.13983333 0.002109559 0.002109559 FALSE TRUE
MSTRG.30778.5 ENSG00000122779 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM24 protein_coding   16.25983 7.125058 24.41905 0.9101169 0.1395932 1.775601 8.2958109 1.4247492 13.7150925 0.7278341 0.20810743 3.257945 0.42853750 0.1771000 0.561633333 0.38453333 0.300809185 0.002109559 FALSE TRUE
MSTRG.30778.6 ENSG00000122779 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM24 protein_coding   16.25983 7.125058 24.41905 0.9101169 0.1395932 1.775601 0.2255926 0.4687324 0.1458493 0.2383004 0.08322348 -1.619068 0.02620833 0.0745000 0.005966667 -0.06853333 0.336070440 0.002109559 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122779 E001 35.5032755 0.0007598377 6.714915e-07 5.787101e-06 7 138460259 138460434 176 + 1.630 1.308 -1.111
ENSG00000122779 E002 49.3845996 0.0008937247 7.983008e-14 2.302614e-12 7 138460435 138460606 172 + 1.794 1.347 -1.528
ENSG00000122779 E003 91.6821747 0.0003441680 2.805839e-25 3.134185e-23 7 138460607 138460912 306 + 2.060 1.603 -1.540
ENSG00000122779 E004 0.6955713 0.0174085837 4.636566e-01 6.034263e-01 7 138461065 138461302 238 + 0.158 0.294 1.139
ENSG00000122779 E005 0.8147077 0.1357935712 6.008998e-01 7.220974e-01 7 138495633 138495664 32 + 0.274 0.172 -0.850
ENSG00000122779 E006 0.8448967 0.2984450659 6.679669e-01 7.750854e-01 7 138495665 138495672 8 + 0.220 0.298 0.584
ENSG00000122779 E007 1.1436611 0.1806791119 9.253476e-01 9.570059e-01 7 138495673 138495725 53 + 0.322 0.296 -0.166
ENSG00000122779 E008 108.7262926 0.0003038491 2.192039e-20 1.466368e-18 7 138504290 138504408 119 + 2.116 1.763 -1.188
ENSG00000122779 E009 0.0000000       7 138514400 138514589 190 +      
ENSG00000122779 E010 0.0000000       7 138514590 138514844 255 +      
ENSG00000122779 E011 131.1001385 0.0003436163 2.428139e-21 1.813180e-19 7 138515212 138515359 148 + 2.191 1.863 -1.101
ENSG00000122779 E012 116.5671507 0.0047599034 6.107760e-09 7.846852e-08 7 138519189 138519321 133 + 2.130 1.855 -0.922
ENSG00000122779 E013 115.4845053 0.0090115460 2.759343e-04 1.281688e-03 7 138525241 138525357 117 + 2.105 1.912 -0.646
ENSG00000122779 E014 112.1547346 0.0007466365 1.272929e-05 8.255537e-05 7 138529116 138529230 115 + 2.079 1.930 -0.501
ENSG00000122779 E015 123.9659807 0.0060085966 3.423857e-03 1.150845e-02 7 138538657 138538803 147 + 2.116 1.988 -0.429
ENSG00000122779 E016 112.4542302 0.0002728437 3.833624e-05 2.219812e-04 7 138551063 138551180 118 + 2.078 1.946 -0.443
ENSG00000122779 E017 102.2253545 0.0015713189 2.866081e-01 4.270347e-01 7 138554698 138554769 72 + 2.004 1.978 -0.086
ENSG00000122779 E018 118.6081943 0.0025647030 8.042384e-02 1.602244e-01 7 138554770 138554864 95 + 2.076 2.021 -0.186
ENSG00000122779 E019 100.6858155 0.0003053660 3.951267e-02 9.012988e-02 7 138554865 138554966 102 + 2.008 1.949 -0.201
ENSG00000122779 E020 0.1515154 0.0422041000 1.000000e+00   7 138556269 138556398 130 + 0.086 0.001 -7.091
ENSG00000122779 E021 192.5252781 0.0002507978 1.004728e-03 3.974844e-03 7 138567481 138567654 174 + 2.290 2.217 -0.244
ENSG00000122779 E022 187.3347884 0.0002131000 6.030634e-02 1.271321e-01 7 138570830 138571003 174 + 2.265 2.232 -0.113
ENSG00000122779 E023 128.9986835 0.0089840639 3.091804e-01 4.514506e-01 7 138573507 138573642 136 + 2.068 2.146 0.261
ENSG00000122779 E024 114.1595813 0.0033226727 5.600523e-01 6.880993e-01 7 138576373 138576445 73 + 2.028 2.073 0.149
ENSG00000122779 E025 80.3832260 0.0003593878 9.257428e-01 9.572577e-01 7 138577420 138577434 15 + 1.885 1.906 0.072
ENSG00000122779 E026 184.3025371 0.0008880833 9.428936e-01 9.681754e-01 7 138577435 138577588 154 + 2.241 2.257 0.054
ENSG00000122779 E027 295.1032577 0.0002637144 1.079678e-02 3.067836e-02 7 138579204 138579532 329 + 2.422 2.495 0.244
ENSG00000122779 E028 193.1415223 0.0002285226 2.200905e-05 1.351249e-04 7 138580562 138580694 133 + 2.218 2.347 0.430
ENSG00000122779 E029 145.7312439 0.0002370579 4.722983e-07 4.198559e-06 7 138581697 138581771 75 + 2.077 2.246 0.564
ENSG00000122779 E030 180.3177543 0.0002236918 2.871538e-13 7.651255e-12 7 138583850 138583999 150 + 2.149 2.362 0.714
ENSG00000122779 E031 734.5523996 0.0012056535 8.717365e-38 2.633937e-35 7 138584742 138589996 5255 + 2.740 2.992 0.839