ENSG00000122778

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000422774 ENSG00000122778 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1549 protein_coding protein_coding 5.90087 4.183565 6.196612 0.4777821 0.1747093 0.5656289 1.7179563 1.73292914 1.6693264 0.24595526 0.2205430 -0.05363128 0.3053375 0.4137667 0.2679000 -0.14586667 0.07108707 0.0117818 FALSE TRUE
ENST00000440172 ENSG00000122778 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1549 protein_coding protein_coding 5.90087 4.183565 6.196612 0.4777821 0.1747093 0.5656289 1.1868997 0.84549999 1.3819808 0.07459041 0.3245271 0.70229955 0.2089458 0.2120667 0.2260333 0.01396667 0.97183591 0.0117818 FALSE TRUE
MSTRG.30785.3 ENSG00000122778 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1549 protein_coding   5.90087 4.183565 6.196612 0.4777821 0.1747093 0.5656289 2.6504011 1.54918393 2.2501726 0.38225066 0.1068338 0.53564184 0.4319292 0.3585667 0.3640667 0.00550000 1.00000000 0.0117818 TRUE TRUE
MSTRG.30785.5 ENSG00000122778 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1549 protein_coding   5.90087 4.183565 6.196612 0.4777821 0.1747093 0.5656289 0.2556379 0.05595185 0.8951326 0.03218944 0.3015110 3.77864415 0.0407125 0.0156000 0.1420000 0.12640000 0.01178180 0.0117818 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122778 E001 404.828952 0.0034998080 8.425082e-01 9.018714e-01 7 138831381 138837226 5846 - 2.613 2.600 -0.043
ENSG00000122778 E002 71.322905 0.0004143896 1.680947e-11 3.373773e-10 7 138837227 138837433 207 - 1.687 1.956 0.906
ENSG00000122778 E003 54.382601 0.0021348559 7.237521e-09 9.151215e-08 7 138837434 138837524 91 - 1.556 1.845 0.979
ENSG00000122778 E004 79.978688 0.0090625930 7.869345e-05 4.218039e-04 7 138837525 138837714 190 - 1.770 1.992 0.749
ENSG00000122778 E005 36.471116 0.0152198110 7.695090e-02 1.546143e-01 7 138837715 138837746 32 - 1.499 1.623 0.423
ENSG00000122778 E006 113.545941 0.0002929131 1.137757e-03 4.429879e-03 7 138837747 138838112 366 - 2.005 2.091 0.289
ENSG00000122778 E007 29.546747 0.0139403467 2.509751e-01 3.871106e-01 7 138838113 138838160 48 - 1.442 1.515 0.251
ENSG00000122778 E008 61.757672 0.0226993641 6.145163e-02 1.290768e-01 7 138840133 138840278 146 - 1.722 1.853 0.444
ENSG00000122778 E009 58.344360 0.0015274461 4.992159e-03 1.590725e-02 7 138844317 138844474 158 - 1.704 1.820 0.392
ENSG00000122778 E010 36.653023 0.0005914770 8.685647e-02 1.703667e-01 7 138852223 138852269 47 - 1.528 1.606 0.265
ENSG00000122778 E011 90.678556 0.0007700306 2.572147e-01 3.942791e-01 7 138861139 138861456 318 - 1.940 1.963 0.077
ENSG00000122778 E012 63.312821 0.0004315029 3.988509e-02 9.082082e-02 7 138867975 138868128 154 - 1.765 1.835 0.235
ENSG00000122778 E013 60.142129 0.0036088673 5.034263e-01 6.393937e-01 7 138869538 138869761 224 - 1.777 1.790 0.047
ENSG00000122778 E014 52.948239 0.0084634418 9.318459e-01 9.610626e-01 7 138871157 138871362 206 - 1.730 1.718 -0.041
ENSG00000122778 E015 38.017887 0.0068817302 3.279520e-01 4.714247e-01 7 138879538 138879653 116 - 1.552 1.603 0.173
ENSG00000122778 E016 52.441897 0.0004888057 3.927292e-01 5.366396e-01 7 138881388 138881584 197 - 1.707 1.727 0.069
ENSG00000122778 E017 67.398756 0.0004441327 7.651562e-01 8.479867e-01 7 138894342 138894526 185 - 1.845 1.811 -0.115
ENSG00000122778 E018 66.509471 0.0004037732 3.445991e-01 4.886910e-01 7 138898955 138899132 178 - 1.857 1.795 -0.209
ENSG00000122778 E019 54.915277 0.0005835384 6.773207e-01 7.820640e-01 7 138903588 138903736 149 - 1.763 1.722 -0.139
ENSG00000122778 E020 33.449302 0.0005970559 1.877361e-01 3.108837e-01 7 138905022 138905081 60 - 1.582 1.482 -0.342
ENSG00000122778 E021 61.878608 0.0003848481 8.534540e-01 9.093042e-01 7 138906919 138907102 184 - 1.810 1.780 -0.100
ENSG00000122778 E022 58.790090 0.0004382157 1.107064e-01 2.065674e-01 7 138908991 138909121 131 - 1.819 1.724 -0.318
ENSG00000122778 E023 64.151156 0.0003988227 4.359790e-03 1.414708e-02 7 138911146 138911323 178 - 1.879 1.732 -0.495
ENSG00000122778 E024 42.857078 0.0005054058 1.007493e-02 2.894548e-02 7 138912372 138912460 89 - 1.715 1.556 -0.539
ENSG00000122778 E025 67.230406 0.0005010229 1.623595e-05 1.028129e-04 7 138916748 138917041 294 - 1.927 1.719 -0.703
ENSG00000122778 E026 27.975022 0.0026780642 1.778892e-01 2.984867e-01 7 138917042 138917122 81 - 1.512 1.398 -0.389
ENSG00000122778 E027 250.813328 0.0119111650 7.613587e-08 7.911207e-07 7 138917123 138919438 2316 - 2.533 2.236 -0.993
ENSG00000122778 E028 7.764002 0.0023563161 9.962025e-05 5.200683e-04 7 138981083 138981389 307 - 1.127 0.637 -1.894