ENSG00000122707

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377966 ENSG00000122707 HEK293_OSMI2_2hA HEK293_TMG_2hB RECK protein_coding protein_coding 4.615582 3.180505 6.945065 0.2339904 0.1047184 1.124279 2.3818422 0.9104608 3.4951110 0.07585438 0.10255139 1.9290319 0.4851708 0.2880000 0.50330000 0.215300000 0.0002504584 0.0002504584 FALSE TRUE
ENST00000475774 ENSG00000122707 HEK293_OSMI2_2hA HEK293_TMG_2hB RECK protein_coding processed_transcript 4.615582 3.180505 6.945065 0.2339904 0.1047184 1.124279 0.2503018 0.2983173 0.6002708 0.06002960 0.15232678 0.9850338 0.0561375 0.0922000 0.08693333 -0.005266667 0.9315821982 0.0002504584 TRUE FALSE
ENST00000479053 ENSG00000122707 HEK293_OSMI2_2hA HEK293_TMG_2hB RECK protein_coding processed_transcript 4.615582 3.180505 6.945065 0.2339904 0.1047184 1.124279 0.7827346 0.6287035 1.3533821 0.10090405 0.09013099 1.0939717 0.1704458 0.2003333 0.19463333 -0.005700000 1.0000000000 0.0002504584 FALSE TRUE
MSTRG.32646.2 ENSG00000122707 HEK293_OSMI2_2hA HEK293_TMG_2hB RECK protein_coding   4.615582 3.180505 6.945065 0.2339904 0.1047184 1.124279 1.2007033 1.3430232 1.4963015 0.23590874 0.11212056 0.1548239 0.2882458 0.4194667 0.21510000 -0.204366667 0.0184624208 0.0002504584 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122707 E001 0.000000       9 36036913 36036917 5 +      
ENSG00000122707 E002 1.173852 0.0655909037 8.457494e-01 0.9040610977 9 36036918 36036923 6 + 0.344 0.310 -0.215
ENSG00000122707 E003 3.536528 0.0046592263 3.985341e-01 0.5422750071 9 36036924 36036939 16 + 0.583 0.716 0.572
ENSG00000122707 E004 13.300021 0.0014649663 4.676288e-02 0.1034021827 9 36036940 36037098 159 + 1.060 1.250 0.678
ENSG00000122707 E005 15.348612 0.0011910884 3.511205e-01 0.4953290639 9 36052265 36052323 59 + 1.162 1.250 0.312
ENSG00000122707 E006 3.203333 0.0049469239 1.102206e-01 0.2058677400 9 36056980 36057013 34 + 0.508 0.758 1.089
ENSG00000122707 E007 24.186413 0.0154827828 5.565201e-02 0.1191001855 9 36058827 36058901 75 + 1.313 1.487 0.604
ENSG00000122707 E008 19.219061 0.0067005143 5.011088e-02 0.1093603908 9 36060119 36060155 37 + 1.218 1.390 0.602
ENSG00000122707 E009 27.202719 0.0105433341 5.818177e-02 0.1235123097 9 36063795 36063880 86 + 1.369 1.524 0.535
ENSG00000122707 E010 26.710122 0.0008849232 2.101683e-01 0.3387372306 9 36065577 36065624 48 + 1.384 1.475 0.315
ENSG00000122707 E011 1.632664 0.0089304542 4.493621e-01 0.5905592549 9 36066769 36066870 102 + 0.450 0.311 -0.793
ENSG00000122707 E012 22.812412 0.0008897292 2.671749e-01 0.4054655613 9 36080605 36080638 34 + 1.322 1.409 0.304
ENSG00000122707 E013 54.742836 0.0006183590 7.377731e-02 0.1495622450 9 36083365 36083562 198 + 1.689 1.780 0.310
ENSG00000122707 E014 25.614933 0.0008262778 1.365195e-01 0.2432170144 9 36085175 36085901 727 + 1.358 1.467 0.379
ENSG00000122707 E015 28.185507 0.0109959988 4.845993e-05 0.0002739820 9 36085902 36086195 294 + 1.305 1.636 1.139
ENSG00000122707 E016 31.074119 0.0007203723 1.055314e-01 0.1989156658 9 36087694 36087961 268 + 1.506 1.400 -0.364
ENSG00000122707 E017 28.827782 0.0049302014 4.091433e-02 0.0927258076 9 36091164 36091343 180 + 1.489 1.332 -0.545
ENSG00000122707 E018 27.052125 0.0060723367 1.669634e-02 0.0442667013 9 36100331 36100543 213 + 1.472 1.275 -0.683
ENSG00000122707 E019 18.403249 0.0010209969 3.020314e-03 0.0103263094 9 36102094 36102230 137 + 1.330 1.060 -0.958
ENSG00000122707 E020 22.620160 0.0008894283 5.357795e-02 0.1155116655 9 36105143 36105283 141 + 1.388 1.237 -0.525
ENSG00000122707 E021 26.282169 0.0008122274 5.496970e-02 0.1179397682 9 36107976 36108164 189 + 1.448 1.310 -0.478
ENSG00000122707 E022 17.733811 0.0058260123 8.370369e-02 0.1653467385 9 36109957 36110079 123 + 1.291 1.133 -0.562
ENSG00000122707 E023 15.883681 0.0073785260 8.087828e-04 0.0032898522 9 36112305 36112476 172 + 1.287 0.921 -1.321
ENSG00000122707 E024 20.435393 0.0038912079 2.029442e-04 0.0009764359 9 36116985 36117177 193 + 1.388 1.040 -1.233
ENSG00000122707 E025 17.877365 0.0013005352 2.231059e-04 0.0010624324 9 36118757 36118967 211 + 1.330 0.973 -1.279
ENSG00000122707 E026 8.550723 0.0228795758 4.092986e-01 0.5529042346 9 36120663 36120736 74 + 0.977 0.865 -0.420
ENSG00000122707 E027 18.106527 0.0086914678 4.498321e-01 0.5910298229 9 36121533 36121688 156 + 1.269 1.197 -0.252
ENSG00000122707 E028 80.221365 0.0003672359 8.359810e-02 0.1651777556 9 36122824 36124455 1632 + 1.856 1.929 0.245